Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition
Title | Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition PDF eBook |
Author | Johan Gabrielsson |
Publisher | CRC Press |
Pages | 926 |
Release | 2001-11-30 |
Genre | Medical |
ISBN | 9789186274924 |
This is a revised and very expanded version of the previous second edition of the book. "Pharmacokinetic and Pharmacodynamic Data Analysis" provides an introduction into pharmacokinetic and pharmacodynamic concepts using simple illustrations and reasoning. It describes ways in which pharmacodynamic and pharmacodynamic theory may be used to give insight into modeling questions and how these questions can in turn lead to new knowledge. This book differentiates itself from other texts in this area in that it bridges the gap between relevant theory and the actual application of the theory to real life situations. The book is divided into two parts; the first introduces fundamental principles of PK and PD concepts, and principles of mathematical modeling, while the second provides case studies obtained from drug industry and academia. Topics included in the first part include a discussion of the statistical principles of model fitting, including how to assess the adequacy of the fit of a model, as well as strategies for selection of time points to be included in the design of a study. The first part also introduces basic pharmacokinetic and pharmacodynamic concepts, including an excellent discussion of effect compartment (link) models as well as indirect response models. The second part of the text includes over 70 modeling case studies. These include a discussion of the selection of the model, derivation of initial parameter estimates and interpretation of the corresponding output. Finally, the authors discuss a number of pharmacodynamic modeling situations including receptor binding models, synergy, and tolerance models (feedback and precursor models). This book will be of interest to researchers, to graduate students and advanced undergraduate students in the PK/PD area who wish to learn how to analyze biological data and build models and to become familiar with new areas of application. In addition, the text will be of interest to toxicologists interested in learning about determinants of exposure and performing toxicokinetic modeling. The inclusion of the numerous exercises and models makes it an excellent primary or adjutant text for traditional PK courses taught in pharmacy and medical schools. A diskette is included with the text that includes all of the exercises and solutions using WinNonlin.
Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications
Title | Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications PDF eBook |
Author | J. Gabrielsson |
Publisher | |
Pages | |
Release | 2000 |
Genre | |
ISBN |
Pharmacokinetic and Pharmacodynamic Data Analysis
Title | Pharmacokinetic and Pharmacodynamic Data Analysis PDF eBook |
Author | Johan Gabrielsson |
Publisher | Swedish Pharmaceutical Press |
Pages | 1040 |
Release | 2016-12-14 |
Genre | Drugs |
ISBN | 9789198299106 |
Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications teaches everyday biological data analysis to the undergraduate and graduate levels. Through numerous examples and over 100 tutorials, scientists learn how to use PK/PD seamlessly in a variety of practical areas, from simple plasma kinetics, multi-compartment models, nonlinear kinetics, plasma protein binding, pharmacodynamic models, turnover concepts, receptor binding, functional adaption and rebound, dose-response-time data analysis, inter-species scaling and a lot more. A substantial effort has been invested into the new pharmacokineticsand pharmacodynamics, including many new and updated Case Studies. The text develops a logical, real-world approach to data and reasoning, showing the reader how to: Think both analytically and visually about data Use graphics to make a point Impove your pattern recognition ability Make sound decisions Strategize your data analyses Appreciate more fully the exciting field of Quantitative Pharmacology
Pharmacokinetic/pharmacodynamic Data Analysis
Title | Pharmacokinetic/pharmacodynamic Data Analysis PDF eBook |
Author | Johan Gabrielsson |
Publisher | |
Pages | 654 |
Release | 1994-01-01 |
Genre | Drugs |
ISBN | 9789186274542 |
Pharmacokinetic-Pharmacodynamic Modeling and Simulation
Title | Pharmacokinetic-Pharmacodynamic Modeling and Simulation PDF eBook |
Author | Peter L. Bonate |
Publisher | Springer Science & Business Media |
Pages | 634 |
Release | 2011-07-01 |
Genre | Medical |
ISBN | 1441994858 |
This is a second edition to the original published by Springer in 2006. The comprehensive volume takes a textbook approach systematically developing the field by starting from linear models and then moving up to generalized linear and non-linear mixed effects models. Since the first edition was published the field has grown considerably in terms of maturity and technicality. The second edition of the book therefore considerably expands with the addition of three new chapters relating to Bayesian models, Generalized linear and nonlinear mixed effects models, and Principles of simulation. In addition, many of the other chapters have been expanded and updated.
Neuropsychopharmacology
Title | Neuropsychopharmacology PDF eBook |
Author | Jahangir Moini |
Publisher | Elsevier |
Pages | 600 |
Release | 2023-05-10 |
Genre | Medical |
ISBN | 0323959733 |
Neuropsychopharmacology reviews the principles of pharmacology with a focus on the central nervous system and autonomic nervous system. Beyond autonomic and central nervous system pharmacology, this volume uniquely discusses psychiatric disorders and the pharmacological interventions that are available for conditions including depression, schizophrenia and anxiety disorders. With a focus on these specific body systems, readers will see end-of-chapter questions that offer real-world case studies, as well as multiple-choice questions for further learning. Beneficial features and content also include two extensive examination tests, which each contain 100 questions for better learning or to be used in teaching, and a glossary. Helpful appendices cover high-alert medications and toxicology effects on the nervous system. Each chapter will contain classifications of medications, pharmacokinetics, mechanism of action, clinical indications and toxicities. Describes pharmacology principles pertaining to the central and autonomic nervous system Identifies pharmacological interventions for psychiatric disorders including current evidence-based interventions for depression, schizophrenia and anxiety disorders Features chapter outlines, end-of-chapter questions, real-world case studies and examinations for deeper learning or teaching
Clinical Pharmacokinetics and Pharmacodynamics
Title | Clinical Pharmacokinetics and Pharmacodynamics PDF eBook |
Author | Malcolm Rowland |
Publisher | Lippincott Williams & Wilkins |
Pages | 839 |
Release | 2011 |
Genre | Medical |
ISBN | 9780781750097 |
Rev. ed. of: Clinical pharmacokinetics. 1995.