'Pediatrics and Perinatology: The Scientific Basis' addresses the molecular biology, biochemistry and physiological mechanisms by which the fetus, newborn infant, and child develop normally. Specific disease states that involve abnormalities are examined in detail. All major organ systems are covered (e.g. immune system, cardiovascular system), and in addition, biological areas specific or particularly important to these developmental periods are covered separately (e.g. growth, temperature regulation). Previously entitled 'Perinatal and Pediatric Pathophysiology', the second edition has been extensively revised and updated, to ensure it provides essential information for the trainee paediatrition or neonatologist. The chapters on membrane, cellular and molecular biology and on immunology have been totally rewritten. New chapters have been added on genetics, clinical genetics and on bone, connective tissue and skin development. The chapter on neurophysiology is greatly extended with reference to both basic physiology and developmental aspects.

This issue of Clinics in Perinatology, guest edited by Drs. Alan Spitzer and Dan Ellsbury, examines Quality Improvement in Neonatal and Perinatal Medicine. The first part of the issue addresses Tools of Quality Improvement and includes articles on The Quality Chasm in Neonatal and Perinatal Medicine; Evaluating the Medical Evidence; The Vermont Oxford Network Database; The Pediatrix Clinical Data Warehouse; Role of Regional Collaboratives: The California Perinatal Quality Care Collaborative Model; A Primer on Quality Improvement Methodology; Using Statistical Process Control Methodology; Human Factors in Quality Improvement, Random Safety Audits, Root Cause Analysis, and Failure Mode and Effects Analysis; Collaboration Between Obstetricians and Neonatologists: Perinatal Safety Programs and Improved Clinical Outcomes; and Pay for Performance: A Business Strategy for Quality Improvement in Neonatal-Perinatal Medicine. The second part of this issue addresses Specific Applications of Documented Quality Improvement Methodology in Neonatal and Perinatal Medicine and includes articles on Delivery Room Intervention-Improving the Outcome, Reducing Retinopathy of Prematurity, Improving Breast Milk Use During and After the NICU Stay, Decreasing Catheter Related Bloodstream Infection, and Decreasing Bronchopulmonary Dysplasia.

A few years ago in the book, Die physiologische Entwicklung des Kindes. Vorlesungen ilber funktionelle Padologie (Springer-Verlag, 1959), the then-current state of knowledge in the field of pedology was compiled by pediatricians from the most diverse countries. In contrast to the term "pediatrics," the word "pedo logy" was used to refer to the physiology of the child, because although the physiological development of the child is intimately associated with disturbances of body functions, both are different from experience with adults. Pedology is more comprehensive than physiology, in that it covers both the physiological and psychological development of the normal child. Favorable response to the above-mentioned book stimulated the project of documenting further progress in pedology at certain intervals, especially by authors who themselves had contributed substantially to these advances. In 1965 and 1968, respectively, two volumes under the title Fortschritte der Pado logie were published by Springer-Verlag-Berlin-Heidelberg-New York. Whereas up to now the English language was used in only some of the articles, in the present volume all authors present their papers in English. Marburg, Spring 1973 The Editor Contents W. Schroter (Hamburg): Some Aspects of Enzyme Induction by Substrates in the Neonate. ... 1.

This guide has been developed jointly by the American Academy of Pediatrics and the American College of Obstetricians and Gynecologists, and is designed for use by all personnel involved in the care of pregnant women, their foetuses, and their neonates.

The study of neonatal and pediatric pathophysiology is vital to modern pediatric practice. The pathophysiology of the developing child is dynamic with various interactions occuring with the underlying metabolic and endocrine events of growth. This major textbook systematically describes pediatric physiology and biochemistry, using a scientific approach closely linked with clinical pediatrics, neonatology and fetal medicine. The in-depth explanation of pathophysiology, at the highest levelthat the clinician requires, makes the book ideal for trainees taking Board examinations. This book will rapidly become a major source of reference.