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High-energy charged particles represent a cutting-edge technique in radiation oncology. Protons and carbon ions are used in several centers all over the world for the treatment of different solid tumors. Typical indications are ocular malignancies, tumors of the base of the skull, hepatocellular carcinomas and various sarcomas. The physical characteristics of the charged particles (Bragg peak) allow sparing of much more normal tissues than it is possible using conventional X-rays, and for this reason all pediatric tumors are considered eligible for protontherapy. Ions heavier than protons also display special radiobiological characteristics, which make them effective against radioresistant and hypoxic tumors. On the other hand, protons and ions with high charge (Z) and energy (HZE particles) represent a major risk for human space exploration. The main late effect of radiation exposure is cancer induction, and at the moment the dose limits for astronauts are based on cancer mortality risk. The Mars Science Laboratory (MSL) measured the dose on the route to Mars and on the planet’s surface, suggesting that a human exploration missions will exceed the radiation risk limits. Notwithstanding many studies on carcinogenesis induced by protons and heavy ions, the risk uncertainty remains very high. In this research topic we aim at gathering the experiences and opinions of scientists dealing with high-energy charged particles either for cancer treatment or for space radiation protection. Clinical results with protons and heavy ions, as well as research in medical physics and pre-clinical radiobiology are reported. In addition, ground-based and spaceflight studies on the effects of space radiation are included in this book. Particularly relevant for space studies are the clinical results on normal tissue complications and second cancers. The eBook nicely demonstrates that particle therapy in oncology and protection of astronauts from space radiation share many common topics, and can learn from each other.

This book attempts to cover the fascinating field of physics of relativistic heavy ions, mainly from the experimentalist's point of view. After the introductory chapter on quantum chromodynamics, basic properties of atomic nuclei, sources of relativistic nuclei, and typical detector set-ups are described in three subsequent chapters. Experimental facts on collisions of relativistic heavy ions are systematically presented in 15 consecutive chapters, starting from the simplest features like cross sections, multiplicities, and spectra of secondary particles and going to more involved characteristics like correlations, various relatively rare processes, and newly discovered features: collective flow, high pT suppression and jet quenching. Some entirely new topics are included, such as the difference between neutron and proton radii in nuclei, heavy hypernuclei, and electromagnetic effects on secondary particle spectra.Phenomenological approaches and related simple models are discussed in parallel with the presentation of experimental data. Near the end of the book, recent ideas about the new state of matter created in collisions of ultrarelativistic nuclei are discussed. In the final chapter, some predictions are given for nuclear collisions in the Large Hadron Collider (LHC), now in construction at the site of the European Organization for Nuclear Research (CERN), Geneva. Finally, the appendix gives us basic notions of relativistic kinematics, and lists the main international conferences related to this field. A concise reference book on physics of relativistic heavy ions, it shows the present status of this field.

This book shows how the study of multi-hadron production phenomena in the years after the founding of CERN culminated in Hagedorn's pioneering idea of limiting temperature, leading on to the discovery of the quark-gluon plasma -- announced, in February 2000 at CERN. Following the foreword by Herwig Schopper -- the Director General (1981-1988) of CERN at the key historical juncture -- the first part is a tribute to Rolf Hagedorn (1919-2003) and includes contributions by contemporary friends and colleagues, and those who were most touched by Hagedorn: Tamás Biró, Igor Dremin, Torleif Ericson, Marek Gaździcki, Mark Gorenstein, Hans Gutbrod, Maurice Jacob, István Montvay, Berndt Müller, Grazyna Odyniec, Emanuele Quercigh, Krzysztof Redlich, Helmut Satz, Luigi Sertorio, Ludwik Turko, and Gabriele Veneziano. The second and third parts retrace 20 years of developments that after discovery of the Hagedorn temperature in 1964 led to its recognition as the melting point of hadrons into boiling quarks, and to the rise of the experimental relativistic heavy ion collision program. These parts contain previously unpublished material authored by Hagedorn and Rafelski: conference retrospectives, research notes, workshop reports, in some instances abbreviated to avoid duplication of material, and rounded off with the editor's explanatory notes. About the editor: Johann Rafelski is a theoretical physicist working at The University of Arizona in Tucson, USA. Bor n in 1950 in Krakow, Poland, he received his Ph.D. with Walter Greiner in Frankfurt, Germany in 1973. Rafelski arrived at CERN in 1977, where in a joint effort with Hagedorn he contributed greatly to the establishment of the relativistic heavy ion collision, and quark-gluon plasma research fields. Moving on, with stops in Frankfurt and Cape Town, to Arizona, he invented and developed the strangeness quark flavor as the signature of quark-gluon plasma.