Clinical Trials In Parkinson's Disease
Title | Clinical Trials In Parkinson's Disease PDF eBook |
Author | Santiago Perez-Lloret |
Publisher | Humana |
Pages | 0 |
Release | 2020-08-19 |
Genre | Medical |
ISBN | 9781071609118 |
This volume looks at major clinical trials for motor and non-motor symptoms in Parkinson’s Disease (PD) and covers important aspects, including trial design, sample selection, and outcome selection. Chapters in this book discuss topics such as toxin-based rodent or genetic models of PD; clinical trials for motor symptoms, L-DOPA related motor complications, and gait disorders; clinical trials for mood disorders, troubled sleep, autonomic dysfunction; and clinical trials for disease modifying therapies. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory or research center. Cutting-edge and authoritative, Clinical Trials in Parkinson’s Disease is a valuable resource for clinicians and researchers who want to enhance their interpretation of results from clinical trials and to design their own high-quality trials.
Parkinson's Disease and the Problems of Clinical Trials
Title | Parkinson's Disease and the Problems of Clinical Trials PDF eBook |
Author | Frank Clifford Rose |
Publisher | |
Pages | 207 |
Release | 1992 |
Genre | Antiparkinsonian agents |
ISBN | 9781854630902 |
Virtual Clinical Trials
Title | Virtual Clinical Trials PDF eBook |
Author | National Academies of Sciences, Engineering, and Medicine |
Publisher | National Academies Press |
Pages | 127 |
Release | 2019-11-16 |
Genre | Medical |
ISBN | 0309494885 |
Successful drug development relies on accurate and efficient clinical trials to deliver the best and most effective pharmaceuticals and clinical care to patients. However, the current model for clinical trials is outdated, inefficient and costly. Clinical trials are limited by small sample sizes that do not reflect variations among patients in the real world, financial burdens on participants, and slow processes, and these factors contribute to the disconnect between clinical research and clinical practice. On November 28-29, the National Academies of Sciences, Engineering, and Medicine convened a workshop to investigate the current clinical trials system and explore the potential benefits and challenges of implementing virtual clinical trials as an enhanced alternative for the future. This publication summarizes the presentations and discussions from the workshop.
Parkinson's Disease: Current and Future Therapeutics and Clinical Trials
Title | Parkinson's Disease: Current and Future Therapeutics and Clinical Trials PDF eBook |
Author | Néstor Gálvez-Jiménez |
Publisher | Cambridge University Press |
Pages | 385 |
Release | 2016-03-24 |
Genre | Medical |
ISBN | 1107053862 |
This book emphasizes treatment options for Parkinson's disease, providing the necessary clinical and scientific basis for the foundations of solid therapeutics.
Parkinson's Disease
Title | Parkinson's Disease PDF eBook |
Author | |
Publisher | |
Pages | 50 |
Release | 2004 |
Genre | Parkinson's disease |
ISBN |
Etiology of Parkinson's Disease
Title | Etiology of Parkinson's Disease PDF eBook |
Author | Jonas H. Ellenberg |
Publisher | CRC Press |
Pages | 600 |
Release | 1995-03-01 |
Genre | Medical |
ISBN | 9780824788230 |
This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.
Clinical Studies and Therapies in Parkinson's Disease
Title | Clinical Studies and Therapies in Parkinson's Disease PDF eBook |
Author | Juan Segura-Aguilar |
Publisher | Academic Press |
Pages | 310 |
Release | 2021-06-12 |
Genre | Medical |
ISBN | 0128221585 |
More than 50 years have passed since the use of L-dopa in the palliative treatment of Parkinson's disease, but it remains the most common treatment despite inducing severe side effects such as dyskinesia after 4–6 years of use. Numerous preclinical investigations based on endogenous neurotoxin models have promised various therapies for Parkinson's disease, but these efforts have failed when attempting to transfer these successful results to preclinical studies. Although several publications have warned of these failures, the scientific community remains mostly unaware, and there is a need to focus their efforts on potential therapeutics that can slow or halt development of the disease.Clinical Studies and Therapies in Parkinson's Disease: Translations from Preclinical Models analyzes preclinical models based on exogenous neurotoxins and why they have failed. Neuroscientists, neurologists, and neuropharmacologists will benefit greatly from the book's discussion of these newer models, their benefits, and the need for their implementation. This book also provides the basic concepts of dopamine metabolism for students taking courses in neurochemistry, neuroscience, neuropharmacology, biochemistry, and medicine. - Reviews Parkinson's disease classification, pharmacological therapies, and nonmotor and motor symptoms - Analyzes preclinical models of Parkinson's disease therapies based on exogenous neurotoxins and why they have failed - Reviews genetic preclinical models based on genetic mutations and endogenous neurotoxins - Proposes a more physiological model directly related to the metabolism of dopaminergic neurons - Provides the basic concepts and mechanisms of dopamine metabolism