The squid giant synapse is the single most important model for investigating the transmitter release mechanism in chemical junctions. This unique book, by a leading expert in the field, gives a concise overview of all that has been learned about synaptic transmission in this superb model system. It covers in detail the biophysics of the voltage-dependent calcium currents, calcium concentration microdomains, and much of the molecular basis for the triggering of the secretory event. Ideal for graduate and undergraduate courses, the book includes PC and Macintosh versions of two programs for simulating and manipulating any aspect of synaptic transmission. One program is a modeling tool designed for working neuroscientists, and the other teaches the basic principles of synaptic transmission by allowing students to alter the parameters, essentially without limits, and see the effects on the action potential over time. Anyone studying this central topic of neuroscience will find this book an invaluable resource.

Cellular and Molecular Neurophysiology, Fourth Edition, is the only up-to-date textbook on the market that focuses on the molecular and cellular physiology of neurons and synapses. Hypothesis-driven rather than a dry presentation of the facts, the book promotes a real understanding of the function of nerve cells that is useful for practicing neurophysiologists and students in a graduate-level course on the topic alike. This new edition explains the molecular properties and functions of excitable cells in detail and teaches students how to construct and conduct intelligent research experiments. The content is firmly based on numerous experiments performed by top experts in the field This book will be a useful resource for neurophysiologists, neurobiologists, neurologists, and students taking graduate-level courses on neurophysiology. - 70% new or updated material in full color throughout, with more than 350 carefully selected and constructed illustrations - Fifteen appendices describing neurobiological techniques are interspersed in the text

This book provides the reader with background information on neurotransmitter release. Emphasis is placed on the rationale by which proteins are assigned specific functions rather than just providing facts about function.

with simulations and illustrations by Richard Gray Problem solving is an indispensable part of learning a quantitative science such as neurophysiology. This text for graduate and advanced undergraduate students in neuroscience, physiology, biophysics, and computational neuroscience provides comprehensive, mathematically sophisticated descriptions of modern principles of cellular neurophysiology. It is the only neurophysiology text that gives detailed derivations of equations, worked examples, and homework problem sets (with complete answers). Developed from notes for the course that the authors have taught since 1983, Foundations of Cellular Neurophysiology covers cellular neurophysiology (also some material at the molecular and systems levels) from its physical and mathematical foundations in a way that is far more rigorous than other commonly used texts in this area.

The authoritative reference on NEURON, the simulation environment for modeling biological neurons and neural networks that enjoys wide use in the experimental and computational neuroscience communities. This book shows how to use NEURON to construct and apply empirically based models. Written primarily for neuroscience investigators, teachers, and students, it assumes no previous knowledge of computer programming or numerical methods. Readers with a background in the physical sciences or mathematics, who have some knowledge about brain cells and circuits and are interested in computational modeling, will also find it helpful. The NEURON Book covers material that ranges from the inner workings of this program, to practical considerations involved in specifying the anatomical and biophysical properties that are to be represented in models. It uses a problem-solving approach, with many working examples that readers can try for themselves.

The Laboratory Computer: A Practical Guide for Physiologists and Neuroscientists introduces the reader to both the basic principles and the actual practice of recording physiological signals using the computer. It describes the basic operation of the computer, the types of transducers used to measure physical quantities such as temperature and pressure, how these signals are amplified and converted into digital form, and the mathematical analysis techniques that can then be applied. It is aimed at the physiologist or neuroscientist using modern computer data acquisition systems in the laboratory, providing both an understanding of how such systems work and a guide to their purchase and implementation. The key facts and concepts that are vital for the effective use of computer data acquisition systems A unique overview of the commonly available laboratory hardware and software, including both commercial and free software A practical guide to designing one's own or choosing commercial data acquisition hardware and software

In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period.