Oxidative/energy Metabolism in Neurodegenerative Disorders
Title | Oxidative/energy Metabolism in Neurodegenerative Disorders PDF eBook |
Author | John P. Blass |
Publisher | |
Pages | 472 |
Release | 1999 |
Genre | Medical |
ISBN |
There is solid evidence of abnormalities in oxidative / energy metabolism with neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. The papers contained in this book are an attempt to move studies in this area to a deeper, more mechanistic level.
Oxidative Stress and Neurodegenerative Disorders
Title | Oxidative Stress and Neurodegenerative Disorders PDF eBook |
Author | G. Ali Qureshi |
Publisher | Elsevier |
Pages | 795 |
Release | 2007-03-22 |
Genre | Science |
ISBN | 0080489494 |
Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders.* Contains the latest information on the subject of neurodegenerative disorders* Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems
Cytochrome Oxidase in Neuronal Metabolism and Alzheimer’s Disease
Title | Cytochrome Oxidase in Neuronal Metabolism and Alzheimer’s Disease PDF eBook |
Author | Francisco Gonzalez-Lima |
Publisher | Springer Science & Business Media |
Pages | 294 |
Release | 2013-06-29 |
Genre | Medical |
ISBN | 1475799365 |
This book is based on an international symposium titled "Cytochrome oxidase in energy metabolism and Alzheimer's disease," held as a satellite to the 27th meeting of the Society for Neuroscience, New Orleans, 1997. The symposium was dedicated in honor of Dr. Margaret T. T. Wong-Riley because, in our opinion, the cytochrome oxidase histo chemical method introduced by Dr. Wong-Riley in 1979 was the most significant break through to map energy metabolism in the entire brain since the 2-deoxyglucose method introduced by Dr. Louis Sokoloff and colleagues in 1977. Both of these metabolic map ping techniques have made monumental contributions to brain research by allowing an integral view of brain activity. They have also developed into various specialized tech niques, including applications to the human brain. One of these new applications, which is described in detail in this book, is the quantitative cytochrome oxidase cytochemical method used to study Alzheimer's disease. The objective of this book is to describe the role of cytochrome oxidase in neuronal metabolism and Alzheimer's disease. Whether genetic or environmental, the pathogenesis of Alzheimer's disease involves a cascade of multiple intracellular events, eventually re sulting in failure of oxidative energy metabolism. Could impairment of cytochrome oxi dase in energy metabolism initiate the degenerative process? Cytochrome oxidase function and dysfunction are discussed in relationship to neuronal energy metabolism, neurodegen eration, and Alzheimer's disease. The book is made up of 10 chapters, divided into three major parts.
Mitochondrial Dysfunction and Oxidative Damage in Neurodegenerative Diseases
Title | Mitochondrial Dysfunction and Oxidative Damage in Neurodegenerative Diseases PDF eBook |
Author | M. Flint Beal |
Publisher | Springer |
Pages | 128 |
Release | 1995-01-01 |
Genre | Active oxygen |
ISBN | 9783540588771 |
This book is about the role of both defects in oxidative phosphorylation and oxidative stress in the pathogenesis of neurodegenerative diseases. It describes the relationship between impaired energy metabolism, excytotoxicity and the generation of free radicals. The role of mitochondrial dysfunction in normal aging, and its potential role in the delayed onset of neurodegenerative diseases as well as the result of animal studies using mitochondrial toxins such as MPTP and 3-nitropropionic acid are described. The evidence for both dysfunction and oxidative stress in Alzheimer's disease, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis are critically reviewed. Lastly, five different therapeutic approaches to treatment of neurodegenerative diseases are discussed.
Neurodegenerative Diseases
Title | Neurodegenerative Diseases PDF eBook |
Author | Shamim I. Ahmad |
Publisher | Springer Science & Business Media |
Pages | 421 |
Release | 2012-03-12 |
Genre | Medical |
ISBN | 1461406536 |
The editor of this volume, having research interests in the field of ROS production and the damage to cellular systems, has identified a number of enzymes showing ·OH scavenging activities details of which are anticipated to be published in the near future as confirmatory experiments are awaited. It is hoped that the information presented in this book on NDs will stimulate both expert and novice researchers in the field with excellent overviews of the current status of research and pointers to future research goals. Clinicians, nurses as well as families and caregivers should also benefit from the material presented in handling and treating their specialised cases. Also the insights gained should be valuable for further understanding of the diseases at molecular levels and should lead to development of new biomarkers, novel diagnostic tools and more effective therapeutic drugs to treat the clinical problems raised by these devastating diseases.
The Metabolic-Inflammatory Axis in Brain Aging and Neurodegeneration
Title | The Metabolic-Inflammatory Axis in Brain Aging and Neurodegeneration PDF eBook |
Author | Fei Yin |
Publisher | Frontiers Media SA |
Pages | 161 |
Release | 2017-08-16 |
Genre | |
ISBN | 2889452530 |
Impairment of energy metabolism is a hallmark of brain aging and several neurodegenerative diseases, such as the Alzheimer’s disease (AD). Age- and disease-related hypometabolism is commonly associated with oxidative stress and they are both regarded as major contributors to the decline in synaptic plasticity and cognition. Neuroinflammatory changes, entailing microglial activation and elevated expression of inflammatory cytokines, also correlate with age-related cognitive decline. It is still under debate whether the mitochondrial dysfunction-induced metabolic deficits or the microglia activation-mediated neuroinflammation is the initiator of the cognitive changes in aging and AD. Nevertheless, multiple lines of evidence support the notion that mitochondrial dysfunction and chronic inflammation exacerbate each other, and these mechanistic diversities have cellular redox dysregulation as a common denominator. This research topic focuses on the role of a metabolic-inflammatory axis encompassing the bioenergetic activity, brain inflammatory responses and their redox regulation in healthy brain aging and neurodegenerative diseases. Dynamic interactions among these systems are reviewed in terms of their causative or in-tandem occurrence and how the systemic environment, –e.g., insulin resistance, diabetes, and systemic inflammation–, impacts on brain function.
Natural Products and Brain Energy Metabolism: Astrocytes in Neurodegenerative Diseases, Volume I
Title | Natural Products and Brain Energy Metabolism: Astrocytes in Neurodegenerative Diseases, Volume I PDF eBook |
Author | Fushun Wang |
Publisher | Frontiers Media SA |
Pages | 202 |
Release | 2022-11-11 |
Genre | Science |
ISBN | 2832505201 |