At long last: The second, completely revised edition of this comprehensive standard reference. Alwyn G. Davies has updated the contents of his book to reflect the current state of research into organotin chemistry. He covers all aspects in detail, such as its synthesis, characterization, structures and applications, while also devoting space to such hot topics as environmental issues. This new edition also includes a CD-ROM with more than 5,000 references, making this database an invaluable tool for everyone working in the field. "The text is well written, extremely accessible and very comprehensive: particularly impressive is the inclusion of up-to-the-minute references in these areas...." - Advanced Materials, 13 (1998) "The standard of production is very good, with well-structured tables and an abundance of clear formula schemas, which enable the reader to quickly grasp the essence of the text." - Angewandte Chemie 16, 1997

single toxicant before it, yet one that has now been brought under effective control-at least in estuaries and the nearshore environment. The problem with TBT and its cause was first recognized in France, then in the United Kingdom and the United States of America; and in these and other countries legislation is now in place (see Abel, Chapter 2; Champ and Wade, Chapter 3), but in many countries the hazard is only now being identified. This volume has the important function of making available to all a summary of the results of work on TBT and the main conclusions. It will help to minimize the duplication of research and speed the introduction of legislation around the world to control organotin pollution. It is the more valuable because research on TBT has often been published in less accessible journals and symposium proceedings. This volume brings together accounts of these findings by the major contributors to the TBT story, providing the most comprehensive account to date. The TBT problem has proved to be instructive in a number of different ways beyond the bounds of the specific issue (Stebbing, 1985). Most important is that TBT can be seen as a challenge to monitoring systems for nearshore waters, by which it can be judged how effective monitoring has been in fulfilling its purpose, and what improvements should be made. Most instructive was the time it took to bring TBT under control.

Organotins are widespread contaminants especially of water environments. Their chemically versatile structure makes organotin compounds able to bind to a variety of biomolecules thus widely affecting biological functions. Trisubstituted molecules, namely tributyltin (TBT) and triphenyltin (TPhT), have been widely employed in antifouling paints and are also exploited as plastic stabilizers that unfortunately cause harmful biological effects. Persistent bioaccumulation has resulted in organotins becoming a significant environmental threat. Chapter by chapter, the biological and biochemical effec.

Tin in Organic Synthesis is a systematic presentation of the organic chemistry of tin. This book discusses the significant advances that have been made with regard to the applications of organotin compounds as reagents or intermediates in organic synthesis and points out directions for future developments. This monograph is comprised of 17 chapters divided into four sections. Following a brief introduction to organotin chemistry, the production of the organotin reagents, which are most usually employed in organic synthesis, is described. Special emphasis is placed on the creation of a fresh tin-carbon bond, a preliminary step in numerous fruitful applications. The following chapters are devoted to synthetic applications involving tin-hydrogen, tin-carbon, and tin-heteroatom bonds. The reduction of organic halides, carbonyl compounds, thio, nitrogen compounds, unsaturated carbon-carbon bonds, and seleno and telluro compounds is considered. The discussion then turns to electrophilic cleavages of tin-carbon bonds, which are of possible interest in organic synthesis, along with transmetallation and metallation of organotin compounds. The creation of new carbon-carbon bonds through substitution, addition, or elimination reactions is also examined. The remaining chapters focus on organotin alkoxides, organotin enolates, organotin oxides and peroxides, and organotin esters. This book will be of interest to students and researchers in the field of organic chemistry.

Contamination of the aquatic environment by antifouling compounds has been a topic of increasing importance during the last few years. This book describes advances in antifouling paint biocides, and provides thorough evaluation of research and information on occurrence and levels, environmental fate, analytical techniques and methods for the monitoring and control, environmental modeling, ecotoxicological effects and risk assessment placing emphasis on the knowledge acquired over the last decade.

Metal and metalloid-containing compounds exhibit a wide range of biological and biocidal activities, some of which have been employed in medicines and drugs. Polymers containing metal or metalloid functions become a natural extension of this effort; just as organic compound drugs have been chemically bound to polymers or physically imbibed into polymer matrices in order to provide a variety of useful advantages, the same opportunities exist for using metal and metalloid species. This volume will cover important biomedical applications of organometallic compounds, including metal-labeled DNA on surfaces, artificial metallo-DNA, organotin molecules as anti-cancer drugs, and much more. * Provides useful descriptions of biomedical applications for the reader to apply in his/her research into materials, polymers, and medicine/drug development. * Edited by high-quality team of macromolecular experts from around the world