This conference on Optical Sensing, Imaging and Manipulation for Biological and Biomedical Applications was part of the International Optoelectronics Symposium Held in Taipei, Taiwan on 26-28 July 200 in conjunction with Photonics Taiwan 2000 (See http://www.spie.org/web/meetings/programs/pt00/pt00 home.html.). This conference brings together the state-of-the an biomedical photonics technologies from three continents for future product advancement. The main goal of photonics is aiming high-speed and high-volume communication and computation. Telemedicine and fiber endoscopies can improve the screening of diseases in GI tracts, GYN tracts, dermatology and otorhinolaryngology areas. Miniature optical sources, filters, detectors, spectrometers, optical fibers, and time-resolved devices are needed. The conference papers discuss work in the areas of biomedical imaging, microscopy, spectroscopy, fluorescence, multiphoton microscopy, fiber optics, biochips, and biosensors.