OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 479: Genetic Toxicology: In vitro Sister Chromatid Exchange Assay in Mammalian Cells
Title | OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 479: Genetic Toxicology: In vitro Sister Chromatid Exchange Assay in Mammalian Cells PDF eBook |
Author | OECD |
Publisher | OECD Publishing |
Pages | 5 |
Release | 1986-10-23 |
Genre | |
ISBN | 9264071385 |
The sister chromatid exchange (SCE) assay is a short-term test for the detection of reciprocal exchanges of DNA between two sister chromatids of a duplicating chromosome. Detection of SCEs requires some means of differentially labeling sister ...
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 473: In Vitro Mammalian Chromosomal Aberration Test
Title | OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 473: In Vitro Mammalian Chromosomal Aberration Test PDF eBook |
Author | OECD |
Publisher | OECD Publishing |
Pages | 22 |
Release | 2016-07-29 |
Genre | |
ISBN | 9264264647 |
This test identifies agents that cause structural chromosome aberrations in cultured mammalian somatic cells.
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 482: Genetic Toxicology: DNA Damage and Repair, Unscheduled DNA Synthesis in Mammalian Cells in vitro
Title | OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 482: Genetic Toxicology: DNA Damage and Repair, Unscheduled DNA Synthesis in Mammalian Cells in vitro PDF eBook |
Author | OECD |
Publisher | OECD Publishing |
Pages | 7 |
Release | 1986-10-23 |
Genre | |
ISBN | 926407144X |
The Test Guideline for Unscheduled DNA Synthesis (UDS) in mammalian cells in vitro describes procedures utilizing primary cultures, human lymphocytes or established cell lines, to detect DNA repair synthesis after excision and removal of a stretch ...
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 485: Genetic toxicology, Mouse Heritable Translocation Assay
Title | OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 485: Genetic toxicology, Mouse Heritable Translocation Assay PDF eBook |
Author | OECD |
Publisher | OECD Publishing |
Pages | 6 |
Release | 1986-10-23 |
Genre | |
ISBN | 9264071504 |
The mouse heritable translocation test detects structural and numerical chromosome changes in mammalian germ cells as recovered in first generation progeny. The types of chromosome changes detected in this test system are reciprocal translocations ...
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 481: Genetic Toxicology: Saacharomyces cerevisiae, Miotic Recombination Assay
Title | OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 481: Genetic Toxicology: Saacharomyces cerevisiae, Miotic Recombination Assay PDF eBook |
Author | OECD |
Publisher | OECD Publishing |
Pages | 6 |
Release | 1986-10-23 |
Genre | |
ISBN | 9264071423 |
This assay may be used to measure mitotic recombination (gene conversion or crossingover) in yeast, a eukaryotic micro-organism. Crossing-over is generally assayed by the production of recessive homozygous colonies or sectors produced in a ...
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 470: Mammalian Erythrocyte Pig-a Gene Mutation Assay
Title | OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 470: Mammalian Erythrocyte Pig-a Gene Mutation Assay PDF eBook |
Author | OECD |
Publisher | OECD Publishing |
Pages | 37 |
Release | 2022-06-30 |
Genre | |
ISBN | 9264366067 |
This Test Guideline describes an in vivo erythrocyte Pig-a gene mutation assay (hereafter called the Pig-a assay) which uses an endogenous mammalian gene, the phosphatidylinositol glycan class A gene (Pig-a), as a reporter of somatic-cell gene mutation. In vivo gene mutation tests, such as the Pig-a assay, are especially relevant for assessing mutagenicity because physiological factors, such as absorption of the test chemical from the site of exposure, distribution of the test chemical throughout the test system via systemic circulation, and in vivo metabolism and DNA repair processes, all contribute to the mutagenic responses.
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 475: Mammalian Bone Marrow Chromosomal Aberration Test
Title | OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 475: Mammalian Bone Marrow Chromosomal Aberration Test PDF eBook |
Author | OECD |
Publisher | OECD Publishing |
Pages | 18 |
Release | 2016-07-29 |
Genre | |
ISBN | 9264264787 |
The mammalian in vivo chromosome aberration test is used for the detection of structural chromosome aberrations induced by test compounds in bone marrow cells of animals, usually rodents (rats, mice and Chinese hamsters).