OECD Guidelines for the Testing of Chemicals, Section 1 Test No. 107: Partition Coefficient (n-octanol/water): Shake Flask Method
| Title | OECD Guidelines for the Testing of Chemicals, Section 1 Test No. 107: Partition Coefficient (n-octanol/water): Shake Flask Method PDF eBook |
| Author | OECD |
| Publisher | OECD Publishing |
| Pages | 4 |
| Release | 1995-07-27 |
| Genre | |
| ISBN | 9264069623 |
This Test Guideline describes a method to determine experimentally Pow values in the range log Pow between -2 and 4 (occasionally up to 5). This method can not be used with surface-active materials. The partition coefficient is defined as the ratio ...
OECD Guidelines for the Testing of Chemicals, Section 1 Test No. 117: Partition Coefficient (n-octanol/water), HPLC Method
| Title | OECD Guidelines for the Testing of Chemicals, Section 1 Test No. 117: Partition Coefficient (n-octanol/water), HPLC Method PDF eBook |
| Author | OECD |
| Publisher | OECD Publishing |
| Pages | 12 |
| Release | 2004-11-23 |
| Genre | |
| ISBN | 9264069828 |
This Test Guideline describes the HPLC method, which permits to determine the partition coefficient (n-octanol/water) (Pow). Reverse phase HPLC is performed on analytical columns packed with a solid phase containing long hydrocarbon chains ...
OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 319B: Determination of in vitro intrinsic clearance using rainbow trout liver S9 sub-cellular fraction (RT-S9)
| Title | OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 319B: Determination of in vitro intrinsic clearance using rainbow trout liver S9 sub-cellular fraction (RT-S9) PDF eBook |
| Author | OECD |
| Publisher | OECD Publishing |
| Pages | 36 |
| Release | 2018-06-27 |
| Genre | |
| ISBN | 9264303235 |
The Test Guideline (TG) describes the use of liver S9 sub-cellular fraction (RT-S9) of rainbow trout (Oncorhynchus mykiss) as a metabolising system to determine the clearance (CL, IN VITRO, INT ) of a test chemical using a substrate depletion approach. Introduction of the test chemical to the ...
OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 305: Bioaccumulation in Fish: Aqueous and Dietary Exposure
| Title | OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 305: Bioaccumulation in Fish: Aqueous and Dietary Exposure PDF eBook |
| Author | OECD |
| Publisher | OECD Publishing |
| Pages | 72 |
| Release | 2012-10-02 |
| Genre | |
| ISBN | 9264185291 |
This Test Guideline describes a procedure for characterising the bioconcentration potential of substances in fish, using an aqueous (standard and minimised tests) or dietary exposure, under flow-through conditions (but semi-static regimes are ...
OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 319A: Determination of in vitro intrinsic clearance using cryopreserved rainbow trout hepatocytes (RT-HEP)
| Title | OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 319A: Determination of in vitro intrinsic clearance using cryopreserved rainbow trout hepatocytes (RT-HEP) PDF eBook |
| Author | OECD |
| Publisher | OECD Publishing |
| Pages | 41 |
| Release | 2018-06-27 |
| Genre | |
| ISBN | 9264303219 |
The Test Guideline (TG) describes the use of cryopreserved rainbow trout (Oncorhynchus mykiss) hepatocytes (RT-HEP) as a metabolising system to determine the clearance (CL, IN VITRO, INT) of a test chemical using a substrate depletion approach. Introduction of the test chemical to the RT-HEP ...
OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 320: Determining Anaerobic Transformation of Chemicals in Liquid Manure
| Title | OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 320: Determining Anaerobic Transformation of Chemicals in Liquid Manure PDF eBook |
| Author | OECD |
| Publisher | OECD Publishing |
| Pages | 30 |
| Release | 2022-06-30 |
| Genre | |
| ISBN | 9264466185 |
This Test Guideline describes a standardised method to examine the transformation of chemicals in pig and cattle liquid manure under anaerobic conditions.
OECD Series on Testing and Assessment Guidance Document on Good In Vitro Method Practices (GIVIMP)
| Title | OECD Series on Testing and Assessment Guidance Document on Good In Vitro Method Practices (GIVIMP) PDF eBook |
| Author | OECD |
| Publisher | OECD Publishing |
| Pages | 206 |
| Release | 2018-12-10 |
| Genre | |
| ISBN | 9264304797 |
In the past several decades, there has been a substantial increase in the availability of in vitro test methods for evaluating chemical safety in an international regulatory context. To foster confidence in in vitro alternatives to animal testing, the test methods and conditions under which ...