This document provides the second edition of Guidance Document 23 on Aqueous-Phase Aquatic Toxicity Testing of Difficult Test Chemicals.

This document provides guidance for the testing of substances, and mixtures, classed as “difficult to test” for the purposes of determining their aquatic toxicity.

This document provides a description of a Harmonised System for the Classification of Chemicals which are Hazardous for the Aquatic Environment and guidance to how the system will work.

This document sets out the objectives, organisational context, and plan for a Harmonised Integrated Classification System for Human Health and Environmental Hazards of Chemical Substances and Mixtures.

In the past several decades, there has been a substantial increase in the availability of in vitro test methods for evaluating chemical safety in an international regulatory context. To foster confidence in in vitro alternatives to animal testing, the test methods and conditions under which ...

The Rapid Androgen Disruption Activity Reporter (RADAR) Test Guideline describes an aquatic assay that utilizes transgenic Oryzias latipes (O. latipes, Japanese medaka) eleutheroembryos at day post hatch zero, in a multi-well format to detect chemicals active on the androgen axis.

This Guidance Document provides information for both the regulated community and regulators to assist with the choice of the most appropriate Guideline to enable particular data requirements to be met while reducing the number of animals used and animal suffering.