Of all the Cambridge Platonists, Henry More has attracted the most scholar ly interest in recent years, as the nature and significance of his contribution to the history of thought has come to be better understood. This revival of interest is in marked contrast to the neglect of More's writings lamented even by his first biographer, Richard Ward, a regret echoed two centuries after his 1 death. Since then such attention as there has been to More has not always served him well. He has been dismissed as credulous on account of his belief in witchcraft while his reputation as the most mystical of the Cambridge 2 school has undermined his reputation as a philosopher. Much of the interest in More in the present century has tended to focus on one particular aspect of his writing. There has been considerable interest in his poems. And he has come to the attention of philosophers thanks to his having corresponded with Descartes. Latterly, however, interest in More has been rekindled by renewed interest in the intellectual history of the seventeenth century and Renaissance. And More has been studied in the context of seventeenth-cen tury science and the wider context of seventeenth-century philosophy. Since More is a figure who belongs to the Renaissance tradition of unified sapientia he is not easily compartmentalised in the categories of modern disciplines. Inevitably discussion of anyone aspect of his thought involves other aspects.

In 1996, Alan Sokal, a Professor of Physics at New York University, wrote a paper for the cultural-studies journal Social Text, entitled 'Transgressing the Boundaries: Towards a transformative hermeneutics of quantum gravity'. It was reviewed, accepted and published. Sokal immediately confessed that the whole article was a hoax - a cunningly worded paper designed to expose and parody the style of extreme postmodernist criticism of science. The story became front-page news around the world and triggered fierce and wide-ranging controversy. Sokal is one of the most powerful voices in the continuing debate about the status of evidence-based knowledge. In Beyond the Hoax he turns his attention to a new set of targets - pseudo-science, religion, and misinformation in public life. 'Whether my targets are the postmodernists of the left, the fundamentalists of the right, or the muddle-headed of all political and apolitical stripes, the bottom line is that clear thinking, combined with a respect for evidence, are of the utmost importance to the survival of the human race in the twenty-first century.' The book also includes a hugely illuminating annotated text of the Hoax itself, and a reflection on the furore it provoked.

Georges Canguilhem is one of France's foremost historians of science. Trained as a medical doctor as well as a philosopher, he combined these practices to demonstrate to philosophers that there could be no epistemology without concrete study of the actual development of the sciences and to historians that there could be no worthwhile history of science without a philosophical understanding of the conceptual basis of all knowledge. A Vital Rationalist brings together for the first time a selection of Canguilhem's most important writings, including excerpts from previously unpublished manuscripts and a critical bibliography by Camille Limoges. Organized around the major themes and problems that have preoccupied Canguilhem throughout his intellectual career, the collection allows readers, whether familiar or unfamiliar with Canguilhem's work, access to a vast array of conceptual and concrete meditations on epistemology, methodology, science, and history. Canguilhem is a demanding writer, but Delaporte succeeds in marking out the main lines of his thought with unrivaled clarity; readers will come away with a heightened understanding of the complex and crucial place he holds in French intellectual history.

This book offers a comprehensive set of principles that lead to ideal outcomes following treatment for Head and Neck Cancers, especially in those patients who need major reconstructive procedures. It goes beyond the scope of basic Head and Neck Cancer textbooks, or of reconstructive surgery texts, in that the essential focus is on optimal outcomes beyond fundamental evaluation and management. The book addresses a range of essential aspects: the chapters on Functional and Aesthetic considerations underscore crucial basics that should be understood by all surgeons, while other chapters relevant to all members of the Head and Neck team address Imaging, Robotics, Radiation Morbidities, Prosthetics and Quality of Life. Throughout the book, particular attention is given to high-quality photographs, flow diagrams and tables wherever possible, combined with crisp writing to achieve effective communication. The book is unique in the completeness of its approach: from the time of initial presentation, to the time patients resume their normal lives. Although written primarily for surgeons, its value extends to all members of the multi-disciplinary team managing Head and Neck Cancer patients today.

5. 1. 1 Biological Rhythms and Clocks From an evolutionary perspective, the adaptation of an organism’s behavior to its environment has depended on one of life’s fundamental traits: biological rhythm generation. In virtually all light-sensitive organisms from cyanobacteria to humans, biological clocks adapt cyclic physiology to geophysical time with time-keeping properties in the circadian (24 h), ultradian (24 h) domains (Edmunds, 1988; Lloyd, 1998; Lloyd et al. , 2001; Lloyd and Murray, 2006; Lloyd, 2007; Pittendrigh, 1993; Sweeney and Hastings, 1960) By definition, all rhythms exhibit regular periodicities since they constitute a mechanism of timing. Timing exerted by oscillatory mechanisms are found throughout the biological world and their periods span a wide range from milliseconds, as in the action potential of n- rons and the myocytes, to the slow evolutionary changes that require thousands of generations. In this context, to understand the synchronization of a population of coupled oscillators is an important problem for the dynamics of physiology in living systems (Aon et al. , 2007a, b; Kuramoto, 1984; Strogatz, 2003; Winfree, 1967). Circadian rhythms, the most intensively studied, are devoted to measuring daily 24 h cycles. A variety of physiological processes in a wide range of eukaryotic organisms display circadian rhythmicity which is characterized by the following major properties (Anderson et al. , 1985; Edmunds, 1988): (i) stable, autonomous (self-sustaining) oscillations having a free-running period under constant envir- mental conditions of ca.