Oliver Wendell Holmes Sr., (1809-1894) was a physician by profession but achieved fame as a writer. He was one of the best regarded American poets of the 19th century. In 1833 Holmes attended the famed Ecole de Medecine in Paris. He pursued his medical studies in the Parisian hospital system. He first attained national prominence with his poem Old Ironsides. One of his most popular works was The Autocrat of the Breakfast Table (1857). He was one of the five members of the group known as the Fireside Poets. He contributed poems and essays to the Atlantic Monthly from its inception, and also published novels. Holmes is also known for his writing of several beautiful hymns. In 1846, Holmes coined the word anesthesia. He also developed the popular model of the stereoscope. Amongst his other works are Elsie Venner (1861), The Guardian Angel (1867), The Poet at the Breakfast-Table (1872), John Lothrop Motley: A Memoir (1879), Medical Essays (1883), A Mortal Antipathy: First Opening of the New Portfolio (1885) and Over the Teacups (1891).

Childbed fever was by the far the most common cause of deaths associated with childbirth up to the Second World War throughout Britain and Europe. Otherwise known as puerperal fever, it was an infection which followed childbirth and caused thousands of miserable and agonising deaths every year. This book provides the first comprehensive account of this tragic disease from its recognition in the eighteenth century up to the second half of the twentieth century. Examining this within a broad history of infective diseases, the author goes on to explore ideas from past debates about the nature of infectious diseases and contagion, the discovery of bacteria and antisepsis, and charts the complicated path which led to the discovery of antibiotics. The large majority of deaths from puerperal fever were due to one micro-organism known as Streptococcus pyogenes, and the last chapter presents valuable new ideas on the nature and epidemiology of streptococcal disease up to the present day.