Extraordinary advances in the understanding of the links between nutrition, metabolism, and cardiovascular disease have prompted a systematic reappraisal of knowledge in the field. As a result, it is now imperative that clinicians who care for patients with CVD or its key risk factors have a solid understanding of the often complex interrelationships between cardiovascular health and chronic diseases such as diabetes and obesity. Written by a team of international thought leaders in cardiology, endocrinology, diabetology and nutritional science, this important new book: Examines and updates the role of obesity, hyperlipidemia, diabetes, hypertension, thrombosis, and aging in atherogenesis Describes in detail the scientific and clinical evidence of the etiopathogenesis of ischemic heart disease as well as of peripheral and cerebrovascular disease Focuses on the 6 topics that will be of greatest interest to readers: 1) general nutrition, 2) metabolic syndrome and diabetes, 3) hyperlipidemia and atherosclerosis, 4) hypertension and cerebrovascular disease, 5) hemostasis and thrombosis, 6) aging Throughout the book, in clear and accessible text, contributors illuminate the close relationship between dietary habits, the metabolic processes of nutrients, and their impact on the cardiovascular system, always with an eye on how the physician can use this information to implement better cardiovascular prevention and improve patient care. Nutritional and Metabolic Bases of Cardiovascular Disease is ideal for those who need to update their knowledge of the links between nutrition, metabolism and CVD, from trainees, clinicians and clinical investigators in cardiovascular medicine to endocrinologists, diabetologists, and nutritionists.

A comprehensive, accessible summary of the latest research in heart disease risk factors Cardiovascular Disease (CVD) is a major cause of early death and disability across the world. The major markers of risk—including high blood cholesterol, smoking, and obesity—are well known, but studies show that such markers do not account for all cardiovascular risk. Written by a team of renowned experts in the field, this comprehensive and accessible book examines the evidence for emerging and novel risk factors, and their relationship with diet and nutrition. Fully updated throughout, Cardiovascular Disease: Diet, Nutrition and Emerging Risk Factors, 2nd Edition covers everything from the epidemiology of cardiovascular disease, to genetic factors, to inflammation and much more – offering invaluable advice on reducing risk factors and preventing CVD. This new edition: Authoritatively reports on the link between emerging aspects of diet, lifestyle and cardiovascular disease risk Focuses on novel risk factors of CVD, including the human gut microbiome and fetal and childhood origins, and how it can be prevented Features recommendations for interventions and future research Includes references, commonly asked questions that summarise the take-home messages, and an online glossary Cardiovascular Disease: Diet, Nutrition and Emerging Risk Factors, 2nd Edition is an important book for researchers and postgraduate students in nutrition, dietetics, food science, and medicine, as well as for cardiologists and cardiovascular specialists.

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

This important and timely book comprises the comprehensive andauthoritative independent report of the British NutritionFoundation Task Force on the link between emerging aspects of dietand cardiovascular disease, a major cause of early death anddisability. Written by leading experts in the area, Cardiovascular Disease:Diet, Nutrition and Emerging Risk Factors looks further than thewell recognised factors such as high blood cholesterol and smokingto identify and explore more subtle markers of risk. Chapters include coverage of novel lipid factors, vascularfunction, clotting factors, inflammatory factors, oxidative stressand homocysteine and early origins of adult disease. The impact ofobesity, insulin resistance, genetic predisposition and factorsrelated to adipose tissue are also addressed. Of vital use to awide range of health professionals this cutting-edge book providesthe reader with: * core information for health professionals as well as thoseinvolved in food formulation in the food industry * a dedicated question and answer chapter * important conclusions and recommendations with 'take-homemessages' Dietitians, nutritionists, general and family practitioners,cardiologists, cardiovascular specialists, community nurses,personnel in the food industry involved in product formulation,production, labelling of packaging and marketing will find this avaluable reference. Lecturers, undergraduates and postgraduates innutrition, dietetics, food science and medicine; libraries in allresearch establishments, commercial organisations, medical schoolsand universities where these subjects are studied or taught willalso find this an important addition to their shelves.

Nutrition plays a key role in prevention of cardiovascular disease, the leading cause of death worldwide. Diet influences a broad spectrum of cardiometabolic risk factors, notably a cluster including excess adiposity, dyslipidemia, impaired glucose metabolism and high blood pressure. In the face of the rapidly increasing incidence of obesity and diabetes, maintaining cardiometabolic health through adoption of a healthy lifestyle is a top public health priority. In this book, Nutrition and Cardiometabolic Health, international experts present state-of-the-art scholarly reviews of dietary and lifestyle effects on metabolic systems associated with cardiovascular health and disease. It covers a broad range of topics including biological and behavioral processes regulating food intake; lifestyle and surgical approaches to weight loss; nutritional considerations for optimal cardiometabolic health across the lifespan; the relationship of macronutrients, whole foods and dietary patterns to diabetes and cardiovascular disease; and diet as a modulator of gene expression, epigenetics and the gut microbiome and the relationship of these traits to disorders of metabolism. This book provides its readers with an authoritative view of the present state of knowledge of dietary effects on cardiometabolic health and will be of interest to nutrition and healthcare professionals alike.

Nutrigenetics and Nutrigenomics in The Cardiovascular System