This volume presents advanced bio/medical sciences with a particular value for translating research achievements into daily medical practice in the framework of Predictive, Preventive and Personalised Medicine (3PM/PPPM). First two decades of the 21st century are characterised by epidemics of non-communicable diseases such as many hundreds of millions of patients diagnosed with cardiovascular diseases and the type 2 diabetes mellitus, breast, lung, liver and prostate malignancies, neurological, sleep, mood and eye disorders, amongst others. Consequent socio-economic burden is tremendous. Unprecedented decrease in age of maladaptive individuals has been reported. The absolute majority of expanding non-communicable disorders carry a chronic character, over a couple of years progressing from reversible suboptimal health conditions to irreversible severe pathologies and cascading collateral complications. The paradigm change from reactive to predictive preventive and personalised medicine is essential to promote population health by application of individualised patient profiling, multi-parametric analysis leading to cost-effective targeted prevention. To this end, inadequate data for risk assessment on speed and urgency of COVID-19, combined with increased globalization of human society, led to the rapid spread of COVID-19. Despite an abundance of digital methods that could be used in slowing or stopping this virus and future pandemics, the world remains unprepared, and lessons have not been learned from previous cases of pandemics. The book presents PPPM strategies which might be of great clinical utility for future pandemics. In a long-term way, a significantly improved healthcare economy is one of the clear benefits of the proposed paradigm shift; a tight collaboration between all stakeholders including scientific community, healthcare providers, patient organisations, policy-makers and educators is analysed for the smooth implementation of the 3PM concepts. Further issues linked to big data management and medical ethics have to be carefully treated in the context of application of artificial intelligence in medicine.

This Handbook of Clinical Neurology volume provides a comprehensive multidisciplinary guide to neuroplasticity. Part I of the book summarizes the basic mechanisms of neuroplasticity. Part II focuses on neuroplasticity in movement disorders. Part III focuses on brain oscillations in neurological disorders. Part IV segues into plasticity in neurorehabilitation. Part V summarizes issues of inflammation and autoimmunity in neuroplasticity. The book concludes with part VI on neuroplasticity and psychiatric disorders. Covers basic mechanisms to clinical treatment of neurological disorders Includes inflammation, autoimmunity, genetics, neurophysiology and more Encompasses stroke, Alzheimer's, movement, and psychiatric disorders Provides tools for enhancing recovery

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Neuroplasticity: From Bench to Bedside, Volume 184 in the Handbook of Clinical Neurology series, provides a comprehensive multidisciplinary guide to neuroplasticity. Sections summarize the basic mechanisms of neuroplasticity, focus on neuroplasticity in movement disorders, discuss brain oscillations in neurological disorders, segue into plasticity in neurorehabilitation, and cover issues of inflammation and autoimmunity in neuroplasticity. The book concludes with a section on neuroplasticity and psychiatric disorders. - Covers basic mechanisms and clinical treatment approaches in neurological disorders - Includes inflammation, autoimmunity, genetics, neurophysiology, and more - Encompasses stroke, Alzheimer's, movement and psychiatric disorders - Provides tools for enhancing recovery

A comprehensive, systematic, and advanced review of the scientific, preclinical, and clinical aspects of several major mental illnesses. The illnesses covered range from neurological disorders including Alzheimer's disease, Huntington's disease, and Parkinson's disease, to psychiatric disorders including schizophrenia, autism spectrum disorders, Tourette's syndrome and tic disorders, obsessive-compulsive disorder, unipolar depression, bipolar disorder, and attention deficit hyperactivity disorder. For each disorder, the authors uniformly discuss its incidence and prevalence, etiology, molecular targets and mechanisms of action, brain structures and pathways, animal models, signs and symptoms, genetics, treatments, and related medical terminology.

A survey of over 900 trainees at the Royal College of Psychiatrists (RCPsych) in the United Kingdom showed that over three-quarters of psychiatry trainees desired some knowledge and training in the field of neuropsychiatry. Recent years have given rise to a substantial global focus on integrating neurosciences and neuropsychiatry in psychiatric training. Neuropsychiatry forms an important part of the psychiatric curriculum and is examined in theory and in clinical exams. Similarly, neuropsychiatry is also of interest to neurology trainees, and it is increasingly recognised that all neurology trainees should have some knowledge and experience in neuropsychiatry. Despite this growing interest, there is a dearth of neuropsychiatry textbooks specifically geared towards trainees and other clinicians who are not specialist in the field. Part of the Oxford Textbooks in Psychiatry series, the Oxford Textbook of Neuropsychiatry helps to bridge the gap between general psychiatric textbooks and reference texts in neuropsychiatry. Organised into four sections, the book covers the basic knowledge and skills relevant to neuropsychiatry, the various neuropsychiatric conditions, the principles of treatment, and perspectives for neuropsychiatry worldwide. Chapters have been written by international experts who are leaders in their own fields with the view to taking an evidence-based, up-to-date, global perspective on neuropsychiatric problems and treatment. The book is relevant to trainees in psychiatry, neurology, neurorehabilitation and also to various allied professionals in neuroscience and mental health. It covers core knowledge and skills for practice in all psychiatric disciplines including core knowledge for training in neuropsychiatry. The book meets curriculum requirements for various international training programmes and examinations, and serves as an essential training text book for all psychiatric and neurology trainees worldwide.