Marking the 200th National Meeting of the American Chemical Society, The Division of Nuclear Chemistry and Technology hosted a group of about 90 scientists from 15 different countries to discuss the new trends in radiopharmaceutical synthesis, quality assurance and regulatory control. This event took place in Washington, D.C. on August 27-30, 1990. When I first suggested the idea for this symposium, a group of scientists who pioneered the proposed topics offered their help to organize and run such a big task with me. Their names are listed here in appreciation. Thomas E. Boothe Cyclotron Facility, Mt. Sinai Medical Center, Miami Beach, Florida, USA Robert F. Dannals Division of Nuclear Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA Anthony L. Feliu Julich Nuclear Research Center, Julich, Germany Joanna S. Fowler Chemistry Department, Brookhaven National Laboratory, Upton, New York, USA George W. Kabalka Department of Chemistry, University of Tennessee, Knoxville, Tennessee, USA Hank F. Kung Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA James F. Lamb Imagents, Inc., Houston, Texas, USA Harold A. O'Brien, Jr. Los Alamos National Laboratory, Los Alamos, New Mexico, USA Joseph R. Peterson Dept. of Chemistry, University of Tennessee, Knoxville, Tennessee, USA Hernan Vera Ruiz International Atomic Energy Agency, Vienna, Austria Roy S. Tilbury University of Texas, M. D. Anderson Cancer Center, Houston, Texas, USA In addition, a number of distinguished colleagues have participated in the process of reviewing the manuscripts presented in this volume. Their effort is sincerely acknowledged.

The thoroughly updated new edition of the authoritative reference in Radiopharmaceutical Sciences The second edition of Handbook of Radiopharmaceuticals is a comprehensive review of the field, presenting up-to-date coverage of central topics such as radionuclide production, synthetic methodology, radiopharmaceutical development and regulations, and a wide range of practical applications. A valuable reference work for those new to the Radiopharmaceutical Sciences and experienced professionals alike, this volume explores the latest concepts and issues involving both targeted diagnostic and therapeutic radiopharmaceuticals. Contributions from a team of experts from across sub-disciplines provide readers with an immersive examination of radiochemistry, nuclear medicine, molecular imaging, and more. Since the first edition of the Handbook was published, Nuclear Medicine and Radiopharmaceutical Sciences have undergone major changes. New radiopharmaceuticals for diagnosis and therapy have been approved by the FDA, the number of clinical PET and SPECT scans have increased significantly, and advances in Artificial Intelligence have dramatically improved research techniques. This fully revised edition reflects the current state of the field and features substantially updated and expanded content. New chapters cover topics including current Good Manufacturing Practice (cGMP), regulatory oversight, novel approaches to quality control—ensuring that readers are informed of the exciting developments of recent years. This important resource: Features extensive new and revised content throughout Covers key areas of application for diagnosis and therapy in oncology, neurology, and cardiology Emphasizes the multidisciplinary nature of Radiopharmaceutical Sciences Discusses how drug companies are using modern radiopharmaceutical imaging techniques to support drug discovery Examines current and emerging applications of Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) Edited by recognized experts in radiochemistry and PET imaging, Handbook of Radiopharmaceuticals: Radiochemistry and Applications, 2 nd Edition is an indispensable reference for post-doctoral fellows, research scientists, and professionals in the pharmaceutical industry, and for academics, graduate students, and newcomers in the field of radiopharmaceuticals.

"Completed revised and updated, Radiopharmaceuticals in Nuclear Pharmacy and Nuclear Medicine, 4th Edition is the radiopharmaceutical bible for nuclear pharmacists, nuclear medicine physicians, and nuclear medicine technologists. Useful in educational programs across these disciplines, it also serves as a key reference in preparation for specialty board examination in nuclear medicine and nuclear pharmacy. The book contains essential information required by state and federal radiation licensing organization for specialty practitioners preparing to become authorized nuclear pharmacists or authorized nuclear medicine physicians. Key Features: All chapters are entirely reorganized and revised to reflect the latest developments in the field. Chapters new to the fourth edition cover of range of topics including Adverse Reactions to Radiopharmaceuticals, Pregnancy and Pediatrics, Localization Mechanisms of Radiopharmaceuticals, Non-Radioactive Pharmaceuticals, PET Manufacturing, and Radiopharmaceutical Distribution. Over 500 figures and 200 tables-many in full-color-underscore key concepts. Table of Contents: Diagnostic Imaging, Nuclear Medicine, and Nuclear Pharmacy; Historical Perspectives in Nuclear Pharmacy: Practice, Education and Specialty Certification; Principles of Radioactivity; Radionuclide Production; Interactions of Radiation with Matter; Radiation Detection and Instrumentation; Radiation Safety; Radiation Biology; Radiopharmaceutical Chemistry: General Topics; Radiopharmaceutical Chemistry: Technetium Agents; Radiopharmaceutical Chemistry: Non-Technetium Agents; Radiopharmaceutical Chemistry: PET Agents; The Nuclear Pharmacy; Quality Control in Nuclear Pharmacy; (New Chapter Number) Formulation Problems of Radiopharmaceuticals Considerations for the Safe Handling of Radiolabeled Blood Products PET Manufacturing and Radiopharmaceutical Distribution Licensing and Regulatory Control - Nuclear; Radiopharmaceuticals and the FDA; Radiopharmaceuticals as Compounded Sterile Products; Mechanisms of Localization of Radiopharmaceuticals; Pregnancy, Pediatric and Breastfeeding Considerations; Adverse reactions to radiopharmaceuticals; Non-Radioactive pharmaceuticals used in nuclear medicine; Brain; Thyroid; Heart; Lung; Liver, Spleen, and Gastrointestinal System; Kidney; Bone; Miscellaneous; Whole Body Imaging Procedures; PET Whole Body Imaging Procedures (new title - formerly Clinical PET Procedures); Therapeutic Applications of Radioactive Agents; Index; Appendices"--

First multi-year cumulation covers six years: 1965-70.

To continue the support for the growing trend of chemistry involvement in nuclear medicine, the Division of Nuclear Chemistry and Technology (DNCT) of the American Chemical Society (ACS) planned for a symposium to cover this aspect. This was expressed in arequest to me, as a member of the Program Committee, to organize a symposium on topics related to nuclear and radiochemistry applications to nuclear medicine. Realizing the growing interest in imaging, specially with positron emitting radioisotopes, I invited several colleagues to study with me the idea of imaging centers and the involvement of chemists in their structure and function. The formulated Organizing Committee supported this idea which evolved in proposing an extended international symposium to be held in conjunction with the 206th ACS National meeting in Chicago, Illinois, U. S. A. on August 22-27, 1993. The following are the members of the Organizing Committee: Jorge R. Barrio, Ph. D. Thomas E. Boothe, Ph. D. J. Robert Dahl, Ph. D. Robert F. Dannals, Ph. D. Bruce R. Erdal, Ph. D. Mark M. Goodman, Ph. D. George W. Kabalka, Ph. D. James F. Lamb, Ph. D. Ronald G. Manning, Ph. D. Henry C. Padgett, Ph. D. Roy S. Tilbury, Ph. D. Steven W. Yates, Ph. D. and Ali M. Emran, Ph. D.