Dynamic Treatment Regimes
Title | Dynamic Treatment Regimes PDF eBook |
Author | Anastasios A. Tsiatis |
Publisher | CRC Press |
Pages | 602 |
Release | 2019-12-19 |
Genre | Mathematics |
ISBN | 1498769780 |
Dynamic Treatment Regimes: Statistical Methods for Precision Medicine provides a comprehensive introduction to statistical methodology for the evaluation and discovery of dynamic treatment regimes from data. Researchers and graduate students in statistics, data science, and related quantitative disciplines with a background in probability and statistical inference and popular statistical modeling techniques will be prepared for further study of this rapidly evolving field. A dynamic treatment regime is a set of sequential decision rules, each corresponding to a key decision point in a disease or disorder process, where each rule takes as input patient information and returns the treatment option he or she should receive. Thus, a treatment regime formalizes how a clinician synthesizes patient information and selects treatments in practice. Treatment regimes are of obvious relevance to precision medicine, which involves tailoring treatment selection to patient characteristics in an evidence-based way. Of critical importance to precision medicine is estimation of an optimal treatment regime, one that, if used to select treatments for the patient population, would lead to the most beneficial outcome on average. Key methods for estimation of an optimal treatment regime from data are motivated and described in detail. A dedicated companion website presents full accounts of application of the methods using a comprehensive R package developed by the authors. The authors’ website www.dtr-book.com includes updates, corrections, new papers, and links to useful websites.
Dynamic Treatment Regimes
Title | Dynamic Treatment Regimes PDF eBook |
Author | Anastasios A. Tsiatis |
Publisher | CRC Press |
Pages | 602 |
Release | 2019-12-10 |
Genre | Medical records |
ISBN | 9781498769778 |
"Precision medicine seeks to use data to construct principled, i.e., evidence-based, treatment strategies that dictate where, when, and to whom treatment should be applied. This book provides an accessible yet comprehensive introduction to statistical methodology for dynamic treatment regimes"--
Statistics in Precision Health
Title | Statistics in Precision Health PDF eBook |
Author | Yichuan Zhao |
Publisher | Springer Nature |
Pages | 545 |
Release | |
Genre | |
ISBN | 3031506901 |
New Statistical Methods for Precision Medicine
Title | New Statistical Methods for Precision Medicine PDF eBook |
Author | Ailin Fan |
Publisher | |
Pages | 87 |
Release | 2016 |
Genre | |
ISBN |
Clinical and Statistical Considerations in Personalized Medicine
Title | Clinical and Statistical Considerations in Personalized Medicine PDF eBook |
Author | Claudio Carini |
Publisher | CRC Press |
Pages | 368 |
Release | 2014-03-27 |
Genre | Mathematics |
ISBN | 1466593873 |
Clinical and Statistical Considerations in Personalized Medicine explores recent advances related to biomarkers and their translation into clinical development. Leading clinicians, biostatisticians, regulators, commercial professionals, and researchers address the opportunities and challenges in successfully applying biomarkers in drug discovery and preclinical and clinical development. Robust Biomarkers for Drug Development and Disease Treatment The first four chapters discuss biomarker development from a clinical perspective. Coverage ranges from an introduction to biomarkers to advances in RNAi screens, epigenetics, and rare diseases as targets for personalized medicine approaches. Subsequent chapters examine the statistical considerations in applying a personalized medicine approach, including multiplicity in pharmacogenomics. The last chapter assesses the regulatory issues involved in using biomarkers. Improve Patient Care and Reduce Costs and Side Effects Despite the vast amount of literature on biomarkers, there is no comprehensive book that integrates the clinical and statistical components. This book is one of the first to incorporate both the clinical and statistical aspects of biomarkers in the personalized medicine paradigm. Covering a wide spectrum of personalized medicine-related topics, it presents state-of-the-art techniques for advancing the application of biomarkers in drug discovery and development.
Statistical Methods for Dynamic Treatment Regimes
Title | Statistical Methods for Dynamic Treatment Regimes PDF eBook |
Author | Bibhas Chakraborty |
Publisher | Springer Science & Business Media |
Pages | 220 |
Release | 2013-07-23 |
Genre | Medical |
ISBN | 1461474280 |
Statistical Methods for Dynamic Treatment Regimes shares state of the art of statistical methods developed to address questions of estimation and inference for dynamic treatment regimes, a branch of personalized medicine. This volume demonstrates these methods with their conceptual underpinnings and illustration through analysis of real and simulated data. These methods are immediately applicable to the practice of personalized medicine, which is a medical paradigm that emphasizes the systematic use of individual patient information to optimize patient health care. This is the first single source to provide an overview of methodology and results gathered from journals, proceedings, and technical reports with the goal of orienting researchers to the field. The first chapter establishes context for the statistical reader in the landscape of personalized medicine. Readers need only have familiarity with elementary calculus, linear algebra, and basic large-sample theory to use this text. Throughout the text, authors direct readers to available code or packages in different statistical languages to facilitate implementation. In cases where code does not already exist, the authors provide analytic approaches in sufficient detail that any researcher with knowledge of statistical programming could implement the methods from scratch. This will be an important volume for a wide range of researchers, including statisticians, epidemiologists, medical researchers, and machine learning researchers interested in medical applications. Advanced graduate students in statistics and biostatistics will also find material in Statistical Methods for Dynamic Treatment Regimes to be a critical part of their studies.
Handbook of Statistical Methods for Precision Medicine
Title | Handbook of Statistical Methods for Precision Medicine PDF eBook |
Author | Eric B. Laber |
Publisher | |
Pages | 0 |
Release | 2024-10 |
Genre | Medical |
ISBN | 9781032106168 |