Almost one out of every three US children is overweight or obese, with minority youth at highest risk. There are limited efficacious pediatric obesity interventions available for clinicians, and successful weight loss trials for minority youth are rare. Even fewer interventions have been shown to significantly improve clinical health outcomes such as adiposity, blood pressure, and cholesterol level, and maintenance of behavior change over the long-term remains a challenge Translation I research in which "bench" findings are applied to the "bedside" is uncommon in the behavioral arena. Thus, advances in our understanding of fundamental human processes such as motivation, emotion, cognition, self-regulation, decision-making, stress, and social networks are not being optimally applied to our most pressing behavioral health problems. This issue of Pediatric Clinics will focus on promising behavioral treatments "in the pipeline" that have been translated from basic behavioral science and are the process of refinement and proof of concept testing.

Almost one out of every three US children is overweight or obese, with minority youth at highest risk. There are limited efficacious pediatric obesity interventions available for clinicians, and successful weight loss trials for minority youth are rare. Even fewer interventions have been shown to significantly improve clinical health outcomes such as adiposity, blood pressure, and cholesterol level, and maintenance of behavior change over the long-term remains a challenge Translation I research in which "bench" findings are applied to the "bedside" is uncommon in the behavioral arena. Thus, advances in our understanding of fundamental human processes such as motivation, emotion, cognition, self-regulation, decision-making, stress, and social networks are not being optimally applied to our most pressing behavioral health problems. This issue of Pediatric Clinics will focus on promising behavioral treatments "in the pipeline" that have been translated from basic behavioral science and are the process of refinement and proof of concept testing.

Cystic Fibrosis (CF) is a multisystem disease whose symptoms and signs involve the gastrointestinal tract (thus affecting nutritional status), endocrine system, reproductive system and the respiratory tract (nose, sinuses and lungs). Despite new treatments, the median survival for patients with CF is less than optimal, primarily due to complications of obstructive lung disease. Currently there are approximately 60,000-80,000 people worldwide with CF. The clinical manifestations of CF are caused by dysfunction of CFTR (cystic fibrosis transmembrane conductance regulator), a multifunctional cyclic-AMP regulated ion channel protein. Over time, there has been dramatic improvement in CF patient life expectancy, in large part related to earlier diagnosis (newborn screening), better understanding of molecular genetics and underlying pathophysiology, the integrated and highly specialized Cystic Fibrosis Foundation Accredited Care Centers, and development of a wide range of new treatments and therapies, some of which target the basic CFTR defect. This edition of Pediatric Clinics of North America will offer general pediatricians and family physicians, as well as subspecialists, an update of the extraordinary progress made in the understanding and treatment of Cystic Fibrosis.

In this issue of Pediatric Clinics of North America, guest editors Drs. Gitanjali Srivastava and Eliana M. Perrin bring their considerable expertise to the topic of Obesity. Top experts discuss the latest research, early interventions, and treatments for obesity in pediatric patients, with the goal of helping clinicians intervene to prevent comorbidities, disease, and chronic health conditions into adulthood. Topics include bariatric surgery, pharmacotherapy, screening, and mental health and stigma, and more, providing state-of-the-art data and clinical information needed to improve outcomes in these patients. - Contains 15 relevant, practice-oriented topics including obesity as a health equity issue; the built environment in obesity; overview of pediatric obesity treatment and the new CPG guidelines; the toxic food environment and nutrition; the genetics of obesity; and more. - Provides in-depth clinical reviews on obesity, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Medical Clinics of North America, guest editor Dr. Marie Krousel-Wood brings her considerable expertise to the topic of Current Challenges and New Directions in Preventive Medicine. Top experts in the field provide evidence-based recommendations and strategies for common preventative medicine topics, including screening and vaccinations. - Contains 13 relevant, practice-oriented topics including vaccine preventable diseases and vaccine hesitancy; substance use/opioid use disorder and clinical care; obesity-implementing evidence: strategies in clinical practice; healthcare providers and staff coping and burnout in the era of COVID-19; lifestyle medicine; and more. - Provides in-depth clinical reviews on preventive medicine, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

This second edition of Freemark’s text embodies all of the strengths of the original work but is deeper and broader in scope, with new chapters on emerging themes including metabolomics, genomics, and the roles of gastrointestinal hormones, the microbiome, brown adipose tissue, and endocrine disruptors in the pathogenesis of childhood obesity. Reviews of the effects of weight excess on cognitive performance and immune function complement detailed analyses of the biochemical and molecular pathways controlling the development of childhood adiposity and metabolic disease. Critical assessments of nutritional interventions (including new chapters on infant feeding practices and vegetarian diets) and superb reviews of behavioral counseling, pharmacotherapy, and bariatric surgery provide practical guidance for the management of overweight children. Penetrating analyses of the obesity epidemic in its social, cultural, economic, and political contexts highlight challenges and opportunities for obesity prevention and community action. The perspective is international in scope and reflects the expertise and experience of many of the leading figures in the field. Comprehensive and up-to-date, this new edition of Pediatric Obesity: Etiology, Pathogenesis and Treatment will be an invaluable guide for all healthcare providers and policy makers concerned with the evaluation and care of children with nutritional and metabolic disease and with the societal implications of the obesity epidemic.

In this issue of Pediatric Clinics of North America, guest editors Drs. Gitanjali Srivastava and Eliana M. Perrin bring their considerable expertise to the topic of Obesity. Top experts discuss the latest research, early interventions, and treatments for obesity in pediatric patients, with the goal of helping clinicians intervene to prevent comorbidities, disease, and chronic health conditions into adulthood. Topics include bariatric surgery, pharmacotherapy, screening, and mental health and stigma, and more, providing state-of-the-art data and clinical information needed to improve outcomes in these patients. Contains 15 relevant, practice-oriented topics including obesity as a health equity issue; the built environment in obesity; overview of pediatric obesity treatment and the new CPG guidelines; the toxic food environment and nutrition; the genetics of obesity; and more. Provides in-depth clinical reviews on obesity, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.