Fast-neutron activation cross sections for isotopes of ruthenium, palladium, indium, tin, and iridium have been measured relative to the 56Fe(n, p)56Mn cross section. Powdered metallic samples of natural-isotopic-abundance Ru, Pd, In, Sn, and Ir were irradiated with (14.1 plus or minus 0.5) - MeV neutrons. The activities produced were determined by observing the gamma radiation with a Ge(Li) detector. The experimental values obtained for (n,2n) and (n, p) reactions are compared with the predictions of recently developed empirical and semi-empirical equations, and the usefulness of these equations is discussed. (Author).