This book is a comprehensive reference of the neuraxial route for the delivery of therapeutics. It reviews the historical evolution of this approach from its inception in the later 1800's to present day. This amply referenced text covers basic discussions of spinal anatomy, embryogenesis, neuraxial vascularity, cerebrospinal fluid flow dynamics and parenchymal molecule movement. The pharmacokinetic and pharmacodynamic properties of different intrathecal agents are explored in detail with particular reference to clinical correlates in pain and spasticity. Particular attention is paid to the issues relevant to preclinical models of intrathecal delivery and the assessment of spinal pathologies arising from acute and chronic intrathecal drug delivery. Chapters provide essential discussions of clinical aspects of patient care, including patient evaluation and screening, trialing and device management, troubleshooting problems and addressing complications, best practices, cost-effectiveness and future of the therapy. Clinicians and researchers who practice intrathecal therapy and study neuraxial mechanisms will find Neuraxial Therapeutics, to be an invaluable guide to this treatment modality.

The Essence of Analgesia and Analgesics is an invaluable practical resource for clinicians giving pain relief in any clinical setting, describing the pharmacologic principles and clinical use of all available pain medications. As well as detailed overviews of pain processing and analgesic theory, sections are dedicated to oral and panteral opioid analgesics, neuraxial opioids, NSAIDs, local anesthetics, anticonvulsant type analgesics, NMDA antagonists, alpha adrenergic analgesics, antidepressant analgesics, muscle relaxants, adjuvant medications, and new and emerging analgesics. The concise format of the chapters allows for quick and easy reading and assimilation of information. Enhanced by summary tables and figures, each chapter provides an overview of a particular drug, covering chemical structure, mode of activity, indications, contraindications, common doses and uses, advantages and disadvantages, and drug related adverse events. Key references are also provided. Edited by leading experts in pain management, this is essential reading for any clinician involved in pain management.

This textbook provides an overview of pain management useful to specialists as well as non-specialists, surgeons, and nursing staff.

Rev. ed. of: Applied therapeutics: the clinical use of drugs / edited by Mary Anne Koda-Kimble ... [et al.]. 9th ed. c2009.

Neuromodulation: Comprehensive Textbook of Principles, Technologies, and Therapies, Second Edition, serves as a comprehensive and in-depth reference textbook covering all aspects of the rapidly growing field of neuromodulation. Since the publication of the first edition seven years ago, there has been an explosion of knowledge in neuromodulation, optogenetics, bioelectronics medicine and brain computer interfacing. Users will find unique discussions of the fundamental principles of neuromodulation and therapies, and how they are applied to the brain, spinal cord, peripheral nerves, autonomic nerves and various organs. The book focuses on comprehensive coverage of spinal cord stimulation, non-interventional and interventional brain stimulation, peripheral nerve stimulation, and the emerging fields of neuromodulation, including optogenetics and bioelectronics medicine. - Provides a comprehensive reference that covers all aspects of the growing field of neuromodulation - Written by international, leading authorities in their respective fields of neuromodulation, pain management, functional neurosurgery and biomedical engineering - Includes new chapters on optogenetics, bioelectronics medicine and brain computer interfacing

New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

Surgical Treatment of Hip Arthritis: Reconstruction, Replacement, and Revision, by William J. Hozack, MD, is a state-of-the-art reference that addresses the challenging issues you face in this rapidly growing segment of orthopaedic practice. Inside, you’ll find top surgical management strategies for all types of hip arthroplasty presented by leaders from around the world, along with discussions of possible complications, risks and benefits to specific patient populations, and more. Best of all, this resource also offers access to a companion website where you will find the full text of the book, completely searchable. Includes online access to the full text at expertconsult.com for convenient anytime, anywhere reference. Presents state-of-the-art surgical management strategies for hip arthritis—from reconstruction to replacement to revision—by experts worldwide, for comprehensive guidance in one convenient resource. Offers current information on computer-assisted navigation techniques and minimally invasive techniques, to equip you with the latest surgical options. Provides extensive discussions of the management of a full range of complications to help you overcome the challenges you’ll face. Addresses the rationale for and management of revision surgery, given specific patient problems and intraoperative issues, enabling you to make the best informed surgical decisions. Presents more than 600 illustrations, including original line art, radiologic images, and full-color intraoperative photos, that show you exactly what to look for and how to proceed.