This publication is one of a series of practical field guides produced by the Pan American Health Organization with best practice guidance for immunisation programmes in the region. This guide describes the strategies that have made the elimination of neonatal tetanus in the Americas possible, highlighting the progress made in surveillance to identify and monitor high-risk areas as well as immunisation activities geared towards women of childbearing age who live in those areas. Sections cover: epidemiology, clinical aspects, case definitions and investigations, surveillance, data analysis, control in high risk areas, programme monitoring, vaccine storage and supply.