Improvements in the detection of fetal and neonatal brain injuries, advances in our understanding of the pathophysiology, cellular and molecular bases of encephalopathy, and new treatment options have all combined to produce significant changes in the management of neonatal brain disorders in the past few years. This new edition of Fetal and Neonatal Brain Injury brings the reader fully up to date with all advances in clinical management and outcome assessment. Updated material includes inflammation focusing in particular on chorioamnionitis and fetal brain injury; genetic brain injury; and expanded sections on cholestasis, diabetes, and thyroid disease. An updated, highly illustrated chapter on structural and functional imaging of the fetal and neonatal brain is also included. An outstanding international team of highly experienced neonatologists and maternal-fetal medicine clinicians have produced a practical, authoritative clinical text that gives clear management advice to all clinicians involved in the treatment of these patients.

Authoritative, practical clinical text giving clear management advice on diagnosis, treatment and outcomes of all fetal and neonatal brain injuries.

The immature brain is vulnerable to prenatal and postnatal stress, which may produce brain damage leading to neurological dysfunction in survivors. The articles in this special issue provide new insights into the pathophysiology and treatment of developmental brain injuries and functional outcomes. Information obtained using preclinical models as well as data from clinical studies emphasize the influence of hypoxia-ischemia, excitotoxicity, oxidative stress, seizures and inflammatory mediators on the outcome of developmental brain injury and ultimate neurological outcome. Importantly, several papers report preclinical tests of new therapies that show real promise in preventing injury to the developing brain including erythropoietin, melatonin and steroids. This publication will be of interest to both clinicians and basic scientists who are interested in the developing nervous system, its vulnerability to various pathophysiological processes and the eventual consequences for neurologic development.

The immature brain is vulnerable to prenatal and postnatal stresses, which may produce brain damage leading to neurological dysfunction in survivors. This special issue presents new in-sights into the detection, pathophysiology and treatment of developmental brain injuries. Importantly, several papers in this issue report pre-clinical tests of new therapies that prevent injury to the developing brain including erythropoietin, insulin-like growth factor- 1 peptides and antioxidants. New insights into how to promote brain repair from neural stem cells is also reported. Information obtained from MRI on human infants, combined with data from several animal models, highlights the effects of hypoxia-ischemia interaction, excitotoxicity, oxidative stress, seizures and inflammation on the outcome of developmental brain injury and ultimate neurological outcome. This publication is recommended to both clinicians and basic scientists, who are interested in the developing nervous system, its vulnerability to various pathophysiological processes, and the eventual consequences for neurological development.

Neurology, a volume in Dr. Polin's Neonatology: Questions and Controversies Series, offers expert authority on the toughest neurological challenges you face in your practice. This medical reference book will help you provide better evidence-based care and improve patient outcomes with research on the latest advances. Reconsider how you handle difficult practice issues with coverage that addresses these topics head on and offers opinions from the leading experts in the field, supported by evidence whenever possible. Find information quickly and easily with a consistent chapter organization. Get the most authoritative advice available from world-class neonatologists who have the inside track on new trends and developments in neonatal care. Purchase each volume individually, or get the entire 6-volume set, which includes online access that allows you to search across all titles! Stay current in practice with coverage on current treatment options for neonatal meningitis, the potential impact of stress and pain on the developing brain, and much more. Access the fully searchable text online at www.expertconsult.com.

This book gives an exhaustive account of the classification and management of epileptic disorders. It provides clear didactic guidance on the diagnosis and treatment of epileptic syndromes and seizures through thirteen chapters, complemented by a pharmacopoeia and CD ROM of video-EEGs.