The following papers were presented at an international symposium on the mechanisms and treatment of nausea and vomiting in man held in Oxford in 1984. I believe that this meeting was the first occasion on which representatives from such a wide variety of scientific and clinical specialities had come together to review and debate the spectrum of the vomiting phenomenon. An attempt was made to put before an invited international audience all the pertinent facts on the different facets of the topic and then to encourage extensive discussion of the contentious issues. The first day of the meeting was devoted to the basic science ap proach to the problem and the second day to the more clinical aspects. This format has been broadly retained in the layout of the book, with the addition of summary chapters reviewing each day's contributions and focusing upon areas of particular importance. Acknowledgement must here be made to the enormous input from the many participants who either spoke in the debate or rose and themselves gave small presenta tions in addition to those of the invited speakers. The meeting occurred at a time of increasing interest in the problem of nausea and vomiting, especially because of its importance in cancer chemotherapy and radiation therapy, and even in space travel.

Nausea is a complex sensation that results from the interaction of certain fixed biological factors, such as gender, with changeable psychological factors, such as anxiety. This is the first book to provide a complete, in-depth explanation of what we know about nausea, along with the latest research results on its causes and treatment. As it is the product of long-term collaboration between scientists from the three main approaches to studying and treating nausea--psychology, gastroenterology, and physiology--the information this book provides is both comprehensive and well integrated. The book is divided into two parts, on mechanisms and management, respectively, and four sections. The chapters in Section I introduce the concept of nausea as a protective control mechanism with individual dynamic thresholds, explain the function of nausea, review past and present conceptions of nausea, and describe the prevalence of nausea in different conditions. Section II includes four basic chapters that review what is known about the physiological bases of nausea. Other chapters explore the roles of the central nervous system, autonomic nervous system, endocrine system, and gastric dysrhythmias. Section III presents the difficult problem of measuring nausea, with chapters focusing on measuring nausea in humans and studying it in animals. Section IV forms the second part of the book, on the management of nausea. The main chapters cover nausea and its treatment in several conditions, including chronic nausea, diabetes, pregnancy, post-operative, cancer and its treatment, and provocative motion. A final chapter discusses future research, including three preliminary studies of novel treatment approaches.

A practical resource providing guidance on treatment options and management strategies for postoperative nausea and vomiting.

Ambulatory care can be a challenging setting in which to provide anesthesia – not all patients are suitable for rapid discharge post-operatively and opinions differ as to which types of surgery should be performed as day cases. This comprehensive guide delivers up-to-date, evidence-based advice on how to provide optimal anesthesia care for ambulatory surgery. Written by a leading clinical anesthesiologist, it provides clear guidance about how to handle particular patients in particular situations. The evidence and scientific knowledge for each issue are presented with reference to major studies and review papers, followed by practical advice based on the author's continuous clinical and scientific experience over 30 years. Topics include planning, equipping and staffing ambulatory units, pharmacology, basic concepts of ambulatory care, pre- and post-operative issues and current controversies. Clinical Ambulatory Anesthesia is essential reading for the clinical, postgraduate anesthesiologist as well as nurse anesthetists involved with ambulatory care.

This fourth edition of Autonomic Failure (now available in paperback) covers the many recent advances made in our understanding of the autonomic nervous system. There are 20 new chapters and extensive revisions of all other contributions. Autonomic failure, fourth edition makes diagnosis increasingly precise by fully evaluating the underlying anatomical and functional deficits, thereby allowing more effective treatment. This new edition continues to provide practitioners from a variety of fields, including neurology, cardiology, geriatric medicine, diabetology, and internal medicine, with a rational guide to aid in the recognition and management of autonomic disorders. The book starts with an updated classification of autonomic disorders and a history of the autonomic nervous system. The first two sections of the book deal with the fundamental aspects of autonomic structure, function, and integration. There are new chapters dealing with neurobiology, nerve growth factors, genetic mutations, neural and hormonal control of the cerebral circulation, innervation of the lung, and pathophysiological mechanisms causing nausea and vomiting. Advances in the clinical management of autonomic disorders are critically dependent on the bridge made between the basic and applied sciences.

Prevention and treatment of nausea and emesis are important issues in a patients wellbeing in the clinical setting as well as for the outpatient. Various and still partly unresolved pathomechanisms play a role in nausea and emesis in humans. It is therefore important to compare results from preclinical research in animal models with results from clinical studies. This book combines an overview of the preclinical research on antiemetic drugs and state-of-the art reviews on the prevention and treatment of nausea and emesis. Established treatment regimens are compared with new interesting compounds in clinical trials. An up-to-date overview of the selection of antiemetic drugs, of their dosage and route of administration is given for clinical conditions such as emetogenic anti-cancer chemotherapy, radiation therapy, surgery, and hyperemesis gravidarum. The treatment of nausea and emesis in opioid therapy and in motion sickness is equally outlined. Whereas this book should serve the clinician in making the right choice for every patients need, it also pays significant attention to the interests of scientists in the fields of oncology, nutrition, gastroenterology, obstetrics and gynecology as well as anaesthesia.

Complications in Neuroanesthesia focuses on complications that may arise related to neuroanesthesia practice and discusses its various causes. Each complication is written as a separate chapter, and the pathophysiology and mechanisms of each complication, as well as measures for diagnosis, treatment and prevention are discussed. Towards the end of the book, several case scenarios are provided to the readers that challenge readers to diagnose the possible complication for each case. Chapters include brain and spinal cord problems, cardiovascular and hematological problems, and nerve and muscle problems. Written in a standard format, Complications in Neuroanesthesia provides quick and easy access to understanding problems in neuroanesthesia. It provides insight into all possible complications occurring during perioperative management of neurosurgical and neurologic patients. It is useful for trainees, clinicians, and researchers in the fields of neurosurgery, neurocritical care, and neurology by providing an understanding of preventable mishaps that may occur in neurosurgical or neurologic patients. Quick and easy reference for understanding problems in neuroanesthesia Provides comprehensive insights into all possible complications occurring during perioperative management of neurosurgical and neurologic patients Includes useful section with clinical case studies of complications in neuroanesthesia