Research in nano and cell mechanics has received much attention from the scientific community as a result of society needs and government initiatives to accelerate developments in materials, manufacturing, electronics, medicine and healthcare, energy, and the environment. Engineers and scientists are currently engaging in increasingly complex scientific problems that require interdisciplinary approaches. In this regard, studies in this field draw from fundamentals in atomistic scale phenomena, biology, statistical and continuum mechanics, and multiscale modeling and experimentation. As a result, contributions in these areas are spread over a large number of specialized journals, which prompted the Editors to assemble this book. Nano and Cell Mechanics: Fundamentals and Frontiers brings together many of the new developments in the field for the first time, and covers fundamentals and frontiers in mechanics to accelerate developments in nano- and bio-technologies. Key features: • Provides an overview of recent advances in nano and cell mechanics. • Covers experimental, analytical, and computational tools used to investigate biological and nanoscale phenomena. • Covers fundamentals and frontiers in mechanics to accelerate developments in nano- and bio-technologies. • Presents multiscale-multiphysics modeling and experimentation techniques. • Examines applications in materials, manufacturing, electronics, medicine and healthcare. Nano and Cell Mechanics: Fundamentals and Frontiers is written by internationally recognized experts in theoretical and applied mechanics, applied physics, chemistry, and biology. It is an invaluable reference for graduate students of nano- and bio-technologies, researchers in academia and industry who are working in nano and cell mechanics, and practitioners who are interested in learning about the latest analysis tools. The book can also serve as a text for graduate courses in theoretical and applied mechanics, mechanical engineering, materials science, and applied physics.

This book presents a full spectrum of views on current approaches to modeling cell mechanics. The authors come from the biophysics, bioengineering and physical chemistry communities and each joins the discussion with a unique perspective on biological systems. Consequently, the approaches range from finite element methods commonly used in continuum mechanics to models of the cytoskeleton as a cross-linked polymer network to models of glassy materials and gels. Studies reflect both the static, instantaneous nature of the structure, as well as its dynamic nature due to polymerization and the full array of biological processes. While it is unlikely that a single unifying approach will evolve from this diversity, it is the hope that a better appreciation of the various perspectives will lead to a highly coordinated approach to exploring the essential problems and better discussions among investigators with differing views.

Nanostructures for the Engineering of Cells: Tissues and Organs showcases recent advances in pharmaceutical nanotechnology, with particular emphasis on tissue engineering, organ and cell applications. The book provides an up-to-date overview of organ targeting and cell targeting using nanotechnology. In addition, tissue engineering applications, such as skin regeneration are also discussed. Written by a diverse range of international academics, this book is a valuable research resource for researchers working in the biomaterials, medical and pharmaceutical industries. - Explains how nanomaterials regulate different cell behavior and function as a carrier for different biomolecules - Shows how nanobiomaterials and nanobiodevices are used in a range of treatment areas, such as skin tissue, wound healing and bone regeneration - Discusses nanomaterial preparation strategies for pharmaceutical application and regenerative medicine

"Increasingly, scientists are gaining control over matter at the nanometer scale. Spearheaded by physical scientists operating at the interfaces of physics and biology (such as the author herself), advances in nanoscience and technology are transforming how we think about life and treat human health. This is due to a convergence of size. To do medicine, one must understand and be able to reach the nanoscale environment of healthy cells in tissues and organs, as well as other nano-sized building blocks that constitute a living organism, such as proteins and DNA. The ground-breaking advances being made at the frontiers of nanoscience and -technology, specifically in the areas of biology and medicine, are the subject of this short, popular-level book. Chapter 1 describes how nanotechnology and quantitative methods in biology are progressively being deployed to embrace life in all its multiscale, hierarchical intricacy and multiplicity. Chapters 2 through 4 review how bioinspired and biomimetic nanostructures and nanomachines are being created and integrated into strategies aimed at solving specific medical problems. In particular, Chapter 2 summarizes how scientists are seeking to build artificial nanostructures using both biological molecules and the organizational principles of biology. Chapter 3 gives an account of how nanotechnology is being used to develop drug-delivery strategies that specifically target cancer cells and tumors to improve the efficacy of current cancer chemotherapies. Chapter 4 reviews the science of one of the most potentially transformative scientific fields: tissue engineering. In a concluding chapter (Chapter 5), Contera reviews how nanotechnology, biology, and medicine will continue fusing with other sciences and technologies - incorporating more mathematical and computational modelling, as well as AI and robotics. Nanoscale devices will be used to learn biology; and biology will be used to inspire increasingly sophisticated "transmaterial" devices that mimic some of the characteristics of biology and incorporate new features that are not available in the biological world. The effects on human health and longevity will be profound. In a more personal epilogue, Contera describes the crossroads at which we find ourselves. Accessing our own biology evokes a mixture of possibility and dread. However, Contera maintains that we can create a positive transmaterial world for the benefit of humankind, and she describes ways in which scientists are proactively engaging with the public, politicians, industry, and entrepreneurs, as well as the media and the arts, to communicate the power and risks of new advances and to influence the ways in which new technologies will affect our future"--

This book is an introduction to the mechanical properties, the force generating capacity, and the sensitivity to mechanical cues of the biological system. To understand how these qualities govern many essential biological processes, we also discuss how to measure them. However, before delving into the details and the techniques, we will first learn the operational definitions in mechanics, such as force, stress, elasticity, viscosity and so on. This book will explore the mechanics at three different length scales – molecular, cellular, and tissue levels – sequentially, and discuss the measurement techniques to quantify the intrinsic mechanical properties, force generating capacity, mechanoresponsive processes in the biological systems, and rupture forces.

"The focus of this book is on centrioles -- small organelles adjacent to the nucleus in all human and animal (eucaryotic) cells. It provides the findings and critical analyses of over 750 articles written in this century. In addition to centrioles, the topics include: centrosomes, chromosomes, microtubules and kinetochores, cell division and duplication, and tumor development. The book also includes discussions on centriole dynamics and electromagnetics effects. It concludes with a chapter on centriole errors -- particularly cells with supernumerary centrioles. The book is intended for students, scholars, and researchers studying and working in the field of nuclear mechanics. In addition to the book content, it provides a guide for literature investigation"--Publisher's website