Since 1988, there has been much literature published on the chemistry of nitric oxide, particularly in the field of S-nitrosation and the chemistry of S-nitroso compounds. Written by a chemist for the chemistry community, this book provides an update of the chemistry of nitrosation reactions, dealing with both the synthetic and mechanistic aspects of these reactions. It also looks at the chemistry of nitric oxide in relation to the amazing biological properties of this simple diatomic molecule, which were unknown until around 1990. * Provides an update on previously published literature on nitric oxide chemistry* Contains chapters on reagents for nitrosation, nitrosation at nitrogen, aliphatic and aromatic carbon, oxygen, sulfur and metal centres* Looks at hot research topics such as synthesis, properties and reactions of s-nitrosothiols

Radicals for Life: the Various Forms of Nitric Oxide provides an up-to-date overview of the role of nitrosocompounds and nitrosyl-iron complexes in physiology. Nitrosocompounds can be considered as stabilised forms of nitric oxide, one of the most important regulatory molecules in physiology today. Many nitrosocompounds share some of the physiological functions of nitric oxide, and may be formed inside living organisms. This is the first book to be published that is dedicated to the role of such nitrosocompounds in physiology, with particular emphasis on the nitrosocompounds that are endogenously formed in higher organisms and humans. Points of discussion include: physical and chemical properties of the compounds, the main chemical pathways in vivo, as well as the physiological effects that have been recognised to date. Each of the nineteen chapters is written by distinguished specialists in the field, well known for their original and important contributions to the subject. Also included are results from a wide range of studies in vitro, in cell cultures, animal models and human volunteers. Examples of alternative forms of nitric oxide, with special emphasis on their protective role against widespread human diseases like atherosclerosis, Alzheimer's disease, diabetes, sexual dysfunction, and renal insufficiency to stroke and ischemia are also included. First monograph to consider and provide an overview of endogenous nitrosocompounds and nitrosyl-iron complexes Extensive bibliographic references, written by specialists of human physiology Providing high scientific quality with a focus on implications for human diseases

General Description of the Volume: Nitric Oxide, recently designated "Molecule of the Year," impinges on a wide range of fields in biological research, particularly in the areas of biomedicine and cell and organismal biology, as well as in fundamental chemistry. This volume will be a valuable resource for the experienced researcher as well as for those newly entering the field. This volume continues the coverage of new and important tools for the elucidation of Nitric Oxide action initiated in Volumes 268 and 269 of Methods in Enzymology. Techniques for researching the physiology and toxicity of nitric oxide in cellular and organismal systems are highlighted. General Description of the Series: The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences. Key Features * Biological Activity * NO Donors: Nitrosothiols and Nitroxyls * Peroxynitrite * Oxidant and Antioxidant Action.

This unique sourcebook serves as a comprehensive reference, bridging the well-established chemistry of nitric oxide and the new and exciting role of nitric oxide as an effector and signaling molecule in numerous biological systems. Nitric Oxide: Principles and Actions relates the chemical properties of the molecule to its possible effects on biological systems, under both normal physiological and pathophysiological conditions. Combining the chemistry and analysis of nitric oxide with newer studies of the relevance of the molecule gives this book a long life, making it extremely useful to researchers in a number of areas. Provides a much needed compilation of what is known about nitric oxide and its properties Enables researchers to understand the importance and use of nitric oxide in systems of study Covers an area of tremendous growth in research Provides the first collection of the roles of nitric oxide in microbial and mammalian systems and as a probe of metalloenzymes Presents the historically important role of nitric oxide in food preservation

Investigates the compound formation, bioactivation, and detoxification of the N-nitroso group of compounds, which increasingly appears to be implicated in human carcinogenesis. The topics include exposure, formation, and blocking; nitric oxide; nitrosamine; toxic, mutagenic, and carcinogenic effects; and reactive intermediates. The 45 papers largely report on research rather than review the literature. The symposium that occasioned them was in Washington, DC, in August 1992. Annotation copyright by Book News, Inc., Portland, OR