Radiotherapy (RT) is a cornerstone of cancer treatment, being routinely used for approximately half of cancer patients in high-income countries. Despite the extensive use of RT for over 60 years, its toxicity on normal tissues often limits the treatment of radioresistant tumors and is responsible for significant decrease in patient’s quality of life. However, it was recently established that ultra-high dose rate (UHDR) irradiation induces significantly less normal tissues toxicities, while keeping similar antitumor effect compared to conventional dose rate irradiation. This so called “FLASH Effect" was demonstrated in vivo on different animal models and different organs by delivering the total amount of radiation dose in a very short time ( usually <200 ms), with average dose rates above 40 Gy/s and with different particles including electrons, protons and photons.

Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative, but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good in-depth reviews of cancer topics, and published symposium lectures are often the best overviews available. Unfor tunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes that aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, which is revised frequently to keep the coverage up to date, and which is easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion: first, by dividing the oncology literature into specific subdivisions, such as lung can cer, genitourinary cancer, pediatric oncology, etc.; and second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diag nosis, staging, markers, all forms of treatment modalities, basic biology, and more.

PANCE/PANRE Flash Review is a flashcard-formatted review book for the physician assistant certification and recertification exams. Organized by body system and following the content blueprint from the National Commission on Certification of Physician Assistants, the Flash Review covers comprehensive topics for PANCE or PANRE examinations. This book is the perfect review resource because it allows you to review information in small chunks. A bound-in CD-ROM contains a 300-question pretest and a 300-question posttest to provide extensive exam practice.

This book explores the current difficulties and unsolved problems in the field of particle therapy and, after analysing them, discusses how (and if) innovative Monte Carlo approaches can be used to solve them. Each book chapter is dedicated to a different sub-discipline, including multi-ion treatments, flash-radiotherapy, laser-accelerated beams, nanoparticles effects, binary reactions to enhance radiobiology, and space-related issues. This is the first book able to provide a comprehensive insight into this exciting field and the growing use of Monte Carlo in medical physics. It will be of interest to graduate students in medicine and medical physics, in addition to researchers and clinical staff. Key Features: Explores the exciting and interdisciplinary topic of Monte Carlo in particle therapy and medicine. Addresses common challenges in the field. Edited by an authority on the subject, with chapter contributions from specialists. Pablo Cirrone is a medical physicist and researcher at the Laboratori Nazionali del Sud of INFN, Italy, where he supports and coordinates various experimental groups. Dr. Cirrone is an expert in the use of proton and ion in radiation treatment and of absolute and relative dosimetry in electron, photon and ion beam. He is an expert in the development and test of detectors for medical applications, of the production and use of laser-driven beams for medical and multidisciplinary applications and recipient of the Michael Gotein Award. He is active on many scientific committees and organizes national and international conferences. Giada Petringa is a researcher at the Laboratori Nazionali del Sud of INFN, Italy. Dr. Petringa has a professional experience in the field of Monte Carlo simulations for medical applications, dosimetry, microdosimetry, and diagnostics with conventional and laser-driven proton beams. In 2019 she had a MSCA-IF-2019 (Marie Sklodowska-Curie Actions-Individual Fellowship) grant funded by the European Community in the framework of the H2020 program. She is a member of the Editorial Board of the international journal Physica Medica - European Journal of Medical. She organized more than fifteen international Geant4 Schools. She is an official member of the Geant4 code Collaboration at CERN since 2019. She is a code developer, and she collaborates to maintain two of the official examples of the code.

–Comprehensive, multi-disciplinary text addressing all aspects of head and neck cancer and crosses a wide spectrum of specialists, including surgical, radiation and medical oncologists, dentists, pathologists, radiologists, and nurses. –8 new chapters – 9 with new authors –Revisions highlight new techniques and imaging –New imaging emphasizes diagnostics, image guided therapies, follow-up imaging, and novel imaging approaches –Less basic science and more clinical diagnostics and management –25% new illustrations, along with more color images to assist in diagnostics and therapeutics