Existential risk studies is a growing field that attempts to understand the greatest dangers to humanity from a scientific perspective. This book offers the first scholarly survey of existential risks, from asteroid impacts and climate change to molecular nanotechnology and machine superintelligence. It argues that avoiding an existential catastrophe should be among our highest moral priorities and analyzes a number of risk mitigation strategies to reduce the probability of a worst-case scenario. The dangers facing humanity this century are real and immense, but the future course of civilization is ultimately up to us.

The future of gene editing in humans will involve the use of CRISPR. How we think about the combination of the scientific, ethical, and moral aspects of this technology is paramount to the success or failure of CRISPR in humans. Unfortunately, the current scientific discussion around CRISPR in humans has left ethics trailing behind due to the rapid pace of innovation. New modes of ethics and stakeholder participation are needed to keep pace with rapid scientific advances and provide the necessary policy and ethical frameworks necessary to help CRISPR flourish as an important health care tool to treat human disease. This requires intense interdisciplinary collaboration and discussion between scientists and philosophers, policymakers and legal scholars, and the public. Dr. Michael W. Nestor (a neuroscientist who actively uses CRISPR in pre-clinical research) and Professor Richard Wilson (a philosopher who focuses on anticipatory ethics) set out to develop a new ethical approach considering the use of CRISPR in human targeted therapies. The field of anticipatory ethics is uniquely poised to tackle questions in fast-evolving technical areas where the pace of innovation outstrips traditional philosophical approaches. Furthermore, because of its “anticipatory” nature, this type of analysis provides the opportunity to look ahead and into the future concerning potential uses of CRISPR in humans, uses that are not currently possible. Nestor and Wilson collaborate both scientifically and philosophically in this book to forecast potential outcomes as the scientific and medical community goes beyond using CRISPR to correct genes that underlie diseases where a single gene is involved. Instead, Nestor and Wilson envision CRISPR in complex, multigenic disorders with a specific focus on the use of CRISPR to edit genes involved in mental traits like IQ or other cognitive characteristics. They argue that the use of CRISPR to modify genes that are potentially important for mental traits represents a particular category for special consideration from scientists, policymakers, the public, and other stakeholders. Nestor and Wilson explain why using CRISPR to alter mental states is very different from treating a disease like cancer by combining the latest scientific advancements with anticipatory ethics and philosophical phenomenology. Their analysis considers the role that mental states play in personhood and the lived experience-as genes that can change mental/cognitive attributes like IQ have wide-ranging effects on the lived experience in ways that are categorically different from other attributes. This book was written to set a non-exhaustive framework for shared understanding and discussion across disciplines and appeal to scientists and non-scientists alike. This appeal is made inclusively, inviting all stakeholders to engage in active dialogue about the appropriate context for using CRISPR and other gene-editing technologies in humans. It provides policy analysis and recommendations for assuring the most inclusive, equitable, and ethically sound use of CRISPR in humans, concerning its positive potential to treat mental conditions like depression, schizophrenia, Alzheimer’s disease, autism, and the potential to induce other cognitive enhancements.

This book examines the contributions of the transhumanism approach to technology, in particular the contributed chapters are wary of the implications of this popular idea. The volume is organized into four parts concerning philosophical, military, technological and sociological aspects of transhumanism, but the reader is free to choose various reading patterns. Topics discussed include gene editing, the singularity, ethical machines, metaphors in AI, mind uploading, and the philosophy of art, and some perspectives taken or discussed examine transhumanism within the context of the philosophy of technology, transhumanism as a derailed anthropology, and critical sociological aspects that consider transhumanism in the context of topical concerns such as whiteness, maleness, and masculinity. The book will be of value to researchers engaged with artificial intelligence, and the ethical, societal, and philosophical impacts of science and technology.

This anthology brings together a diversity of key texts in the emerging field of Existential Risk Studies. It serves to complement the previous volume The Era of Global Risk: An Introduction to Existential Risk Studies by providing open access to original research and insights in this rapidly evolving field. At its heart, this book highlights the ongoing development of new academic paradigms and theories of change that have emerged from a community of researchers in and around the Centre for the Study of Existential Risk. The chapters in this book challenge received notions of human extinction and civilization collapse and seek to chart new paths towards existential security and hope. The volume curates a series of research articles, including previously published and unpublished work, exploring the nature and ethics of catastrophic global risk, the tools and methodologies being developed to study it, the diverse drivers that are currently pushing it to unprecedented levels of danger, and the pathways and opportunities for reducing this. In each case, they go beyond simplistic and reductionist accounts of risk to understand how a diverse range of factors interact to shape both catastrophic threats and our vulnerability and exposure to them and reflect on different stakeholder communities, policy mechanisms, and theories of change that can help to mitigate and manage this risk. Bringing together experts from across diverse disciplines, the anthology provides an accessible survey of the current state of the art in this emerging field. The interdisciplinary and trans-disciplinary nature of the cutting-edge research presented here makes this volume a key resource for researchers and academics. However, the editors have also prepared introductions and research highlights that will make it accessible to an interested general audience as well. Whatever their level of experience, the volume aims to challenge readers to take on board the extent of the multiple dangers currently faced by humanity, and to think critically and proactively about reducing global risk.

What are the implications of how we talk about apocalypse? A new philosophical field has emerged. “Existential risk” studies any real or hypothetical human extinction event in the near or distant future. This movement examines catastrophes ranging from runaway global warming to nuclear warfare to malevolent artificial intelligence, deploying a curious mix of utilitarian ethics, statistical risk analysis, and, controversially, a transhuman advocacy that would aim to supersede almost all extinction scenarios. The proponents of existential risk thinking, led by Oxford philosopher Nick Bostrom, have seen their work gain immense popularity, attracting endorsement from Bill Gates and Elon Musk, millions of dollars, and millions of views. Calamity Theory is the first book to examine the rise of this thinking and its failures to acknowledge the ways some communities and lifeways are more at risk than others and what it implies about human extinction. Forerunners: Ideas First is a thought-in-process series of breakthrough digital publications. Written between fresh ideas and finished books, Forerunners draws on scholarly work initiated in notable blogs, social media, conference plenaries, journal articles, and the synergy of academic exchange. This is gray literature publishing: where intense thinking, change, and speculation take place in scholarship.