Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections is a complete examination of the ways in which proteins with more than one unique biological action are able to serve as virulence factors in different bacteria. The book explores the pathogenicity of bacterial moonlighting proteins, demonstrating the plasticity of protein evolution as it relates to protein function and to bacterial communication. Highlighting the latest discoveries in the field, it details the approximately 70 known bacterial proteins with a moonlighting function related to a virulence phenomenon. Chapters describe the ways in which each moonlighting protein can function as such for a variety of bacterial pathogens and how individual bacteria can use more than one moonlighting protein as a virulence factor. The cutting-edge research contained here offers important insights into many topics, from bacterial colonization, virulence, and antibiotic resistance, to protein structure and the therapeutic potential of moonlighting proteins. Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections will be of interest to researchers and graduate students in microbiology (specifically bacteriology), immunology, cell and molecular biology, biochemistry, pathology, and protein science.

The past 25 years has seen the emergence of a wealth of data suggesting that novel biological functions of known proteins play important roles in biology and medicine. This ability of proteins to exhibit more than one unique biological activity is known as protein moonlighting. Moonlighting proteins can exhibit novel biological functions, thus extending the function of the proteome, and are also implicated in the pathology of a growing number of idiopathic and infectious diseases. This book, written by a cell biologist, protein evolutionary biologist and protein bioinformatician, brings together the latest information on the structure, evolution and biological function of the growing numbers of moonlighting proteins that have been identified, and their roles in human health and disease. This information is revealing the enormous importance protein moonlighting plays in the maintenance of human health and in the induction of disease pathology. Protein Moonlighting in Biology and Medicine will be of interest to a general readership in the biological and biomedical research community.

Microbial infection is increasingly seen as a problem as we begin to run out of antibiotics. Understanding how microbes cause disease is essential. In recent years it has begun to emerge that bacteria, fungi, protozoa and viruses can use their cell stress proteins to cause infection. This volume brings together the world's leading experts in the study of the microbial and human cell stress proteins that are involved in enabling microorganisms to infect humans and cause serious disease.

Meet Bella Bree MacGowan ... smart, sexy and wanted for murder. Bella is furious that Lt. Miles Brooks thinks she's actually capable of murder. If he'd concentrate on finding clues, instead of trying to pin the death of her boss on Bree, he might actually catch the perp. If Brooks won't look for clues, then Bree will, regardless of the danger. Finding clues isn't as easy as it seems and Bree looses her boyfriend and her job while in the pursuit of justice. A lethal encounter with the creepy soap star Gunnar Ericson makes her wonder if she'll be able to discover the murderer's identity before she also loses her life... Another chillingly good New England mystery from Mainly Murder Press.

Pride and Prejudice variation. Forced to flee France, in the 12th century, to preserve their community, the werewolves moved to less populated England. Fitzwilliam Darcy lived at Pemberley in the far northern parts of England. He inherited his leadership of the Pemberley pack from his late father. His human mother had passed long before her mate. In an effort to dilute the bloodlines to better control the 'change' the males sought human wives. Darcy's love of Elizabeth Bennet was complete and for life. Bound by the law of the pack to withhold his true identity until his wife was with child, Darcy married Elizabeth Bennet at the same time as his best friend Charles Bingley married her sister, Jane. Now in the far reaches of Pemberley, will Lizzy learn her husband's secret? Will she escape this unnatural community or, will their love prevail against overwhelming odds? What will her life be as the Alpha Female of the werewolves of Pemberley?

"Famed director M. Night Shyamalan tells how his passion for education reform led him to the five indispensable keys to educational success in America's high-performing schools in impoverished neighborhoods"--