Molecularly Targeted Therapy for Childhood Cancer
Title | Molecularly Targeted Therapy for Childhood Cancer PDF eBook |
Author | Peter J. Houghton |
Publisher | Springer Science & Business Media |
Pages | 548 |
Release | 2010-09-10 |
Genre | Medical |
ISBN | 038769062X |
Each chapter will focus on the known molecular characteristics of specific childhood cancers, focusing on how the molecular ‘drivers’ can be exploited from a therapeutic standpoint with currently available targeted agents. Where applicable, integration of targeted therapies with conventional cytotoxic agents will be considered. This volume will provide a comprehensive summary of molecular characteristics of childhood cancers, and how the changes involved in transformation provide us with opportunities for developing relatively less toxic, but curative, therapies.
Molecularly Targeted Therapy for Childhood Cancer
Title | Molecularly Targeted Therapy for Childhood Cancer PDF eBook |
Author | Peter J. Houghton |
Publisher | Springer |
Pages | 536 |
Release | 2010-09-08 |
Genre | Medical |
ISBN | 9780387690605 |
Each chapter will focus on the known molecular characteristics of specific childhood cancers, focusing on how the molecular ‘drivers’ can be exploited from a therapeutic standpoint with currently available targeted agents. Where applicable, integration of targeted therapies with conventional cytotoxic agents will be considered. This volume will provide a comprehensive summary of molecular characteristics of childhood cancers, and how the changes involved in transformation provide us with opportunities for developing relatively less toxic, but curative, therapies.
Hepatocellular Carcinoma
Title | Hepatocellular Carcinoma PDF eBook |
Author | Yujin Hoshida |
Publisher | Springer |
Pages | 366 |
Release | 2019-08-05 |
Genre | Medical |
ISBN | 3030215407 |
This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields. By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.
Childhood Cancer and Functional Impacts Across the Care Continuum
Title | Childhood Cancer and Functional Impacts Across the Care Continuum PDF eBook |
Author | National Academies of Sciences Engineering and Medicine |
Publisher | |
Pages | |
Release | 2021-09-09 |
Genre | |
ISBN | 9780309683494 |
Since the late 1960s, the survival rate in children and adolescents diagnosed with cancer has steadily improved, with a corresponding decline in the cancer-specific death rate. Although the improvements in survival are encouraging, they have come at the cost of acute, chronic, and late adverse effects precipitated by the toxicities associated with the individual or combined use of different types of treatment (e.g., surgery, radiation, chemotherapy). In some cases, the impairments resulting from cancer and its treatment are severe enough to qualify a child for U.S. Social Security Administration disability benefits. At the request of Social Security Administration, Childhood Cancer and Functional Impacts Across the Care Continuum provides current information and findings and conclusions regarding the diagnosis, treatment, and prognosis of selected childhood cancers, including different types of malignant solid tumors, and the effect of those cancers on childrenâ (TM)s health and functional capacity, including the relative levels of functional limitation typically associated with the cancers and their treatment. This report also provides a summary of selected treatments currently being studied in clinical trials and identifies any limitations on the availability of these treatments, such as whether treatments are available only in certain geographic areas.
Biology-Driven Targeted Therapy of Pediatric Soft-Tissue and Bone Tumors: Current Opportunities and Future Challenges
Title | Biology-Driven Targeted Therapy of Pediatric Soft-Tissue and Bone Tumors: Current Opportunities and Future Challenges PDF eBook |
Author | Thomas G. P. Grünewald |
Publisher | Frontiers Media SA |
Pages | 149 |
Release | 2016-04-05 |
Genre | Cancer in children |
ISBN | 2889198197 |
Recent advances in the understanding of the biological basis of pediatric soft-tissue and bone tumors, especially owing to the advent of “omics” technologies, have led to an exponential increase in the current knowledge on the genetic and cellular patho-mechanisms that drive these diseases. This offers the unprecedented opportunity to develop and implement targeted therapies such as monoclonal antibodies, small molecules, oncolytic viruses, and immunotherapies in standard and/or personalized treatment regimens. However, to date only a few examples document a successful translation of discoveries from the bench to the bedside. Recent international expert congresses further emphasize the urgent need for a more rapid and especially more successful translational process. Hence, we strongly believe that a Frontiers Research Topic aiming at this aspect would fit just in time and be relevant for a broad readership. This Frontiers Research Topic intended to provide a platform for active and interdisciplinary discussion, to summarize current state-of-the-art knowledge on all basic research and translational aspects in pediatric soft-tissue and bone tumors, and to offer new perspectives on how to further promote and accelerate the translational process. It comprises high-quality original articles and timely reviews.
Childhood Acute Lymphoblastic Leukemia
Title | Childhood Acute Lymphoblastic Leukemia PDF eBook |
Author | Ajay Vora |
Publisher | Springer |
Pages | 345 |
Release | 2017-04-21 |
Genre | Medical |
ISBN | 3319397087 |
This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.
Molecular Targeted Therapy in Oncology: Lessons from Pharmacogenetics and Pharmacoepigenetics
Title | Molecular Targeted Therapy in Oncology: Lessons from Pharmacogenetics and Pharmacoepigenetics PDF eBook |
Author | Saber Imani |
Publisher | Frontiers Media SA |
Pages | 146 |
Release | 2022-04-06 |
Genre | Science |
ISBN | 2889748553 |