Molecular Mechanisms of Cell Differentiation in Gonad Development
Title | Molecular Mechanisms of Cell Differentiation in Gonad Development PDF eBook |
Author | Rafal P. Piprek |
Publisher | Springer |
Pages | 444 |
Release | 2016-06-14 |
Genre | Science |
ISBN | 3319319736 |
This book presents the current state of knowledge on the origin and differentiation of cell lines involved in the development of the vertebrate male and female gonads with particular emphasis on the mouse. It also discusses the processes leading to the testis- and ovary-specific structures and functions. The individual chapters review the origin and differentiation of the somatic cells of the genital ridges; the formation and migration of primordial germ cells in mouse and man; the gonadal supporting cell lineage and mammalian sex determination; differentiation of Sertoli and granulosa cells; mesonephric cell migration into the gonads and vascularization; origin and differentiation of androgen-producing cells in the gonads; germ cell commitment to the oogenic versus spermatogenic pathway and the role of retinoic acid; ovarian folliculogenesis; control of oocyte growth and development by intercellular communication within the follicular niche; biology of the Sertoli cell in the fetal, pubertal and adult mammalian testis; mechanisms regulating spermatogonial differentiation; stem cells in mammalian gonads; the role of microRNAs in cell differentiation during gonad development; human sex development and its disorders; as well as methods for the study of gonadal development.
Molecular Mechanisms in Spermatogenesis
Title | Molecular Mechanisms in Spermatogenesis PDF eBook |
Author | C.Y. Cheng |
Publisher | Springer Science & Business Media |
Pages | 289 |
Release | 2009-10-24 |
Genre | Science |
ISBN | 0387095977 |
In the past thirty years, significant advances have been made in the field of reproductive biology in unlocking the molecular and biochemical events that regulate spermatogenesis in the mammalian testis. It was possible because of the unprecedented breakthroughs in molecular biology, cell biology, immunology, and biochemistry. In this book entitled, Molecular Mechanisms in Spermatogenesis, a collection of chapters has been included written by colleagues on the latest development in the field using genomic and proteomic approaches to study spermatogenesis, as well as different mechanisms and/or molecules including environmental toxicants and transcription factors that regulate and/or affect spermatogenesis. The book begins with a chapter that provides the basic concept of cellular regulation of spermatogenesis. A few chapters are also dedicated to some of the latest findings on the Sertoli cell cytoskeleton and other molecules (e.g., proteases, adhesion proteins) that regulate spermatogenesis. These chapters contain thought-provoking discussions and concepts which shall be welcomed by investigators in the field. It is obvious that many of these concepts will be updated and some may be amended in the years to come. However, they will serve as a guide and the basis for investigation by scientists in the field.
Molecular Biology of the Cell
Title | Molecular Biology of the Cell PDF eBook |
Author | |
Publisher | |
Pages | 0 |
Release | 2002 |
Genre | Cells |
ISBN | 9780815332183 |
Cellular and Molecular Biology of Gonadal Development and Maturation in Mammals
Title | Cellular and Molecular Biology of Gonadal Development and Maturation in Mammals PDF eBook |
Author | Sardul S. Guraya |
Publisher | Springer |
Pages | 0 |
Release | 1998 |
Genre | Gonads |
ISBN | 9780387636900 |
This book provides a critical, up-to-date review of the vast body of recent research on the cellular and molecular biology of development, differentiation and maturation of the ovary and testis in mammals including human. It also explores the current concepts and theories of gonadal differentiation as well as the origin, migration and structure of germ cells. Results on the morphological, ultrastructural, histochemical, immunological, biochemical including in vitro, experiments, physiological, endocrinological, cytogenetical, genetical and molecular aspects of germ cells and somatic tissues involved are especially compared and contrasted across species for the better understanding of their structure-chemistry-function and the regulatory mechanisms involved at different stages of development and maturation of ovary and testis. This book will be of great interest to research scientists and students in the fields of reproductive biology and biomedicine, endocrinology, developmental biology, zoology, animal physiology, animal breeding, etc.
Maternal-Fetal and Neonatal Endocrinology
Title | Maternal-Fetal and Neonatal Endocrinology PDF eBook |
Author | Christopher S. Kovacs |
Publisher | Academic Press |
Pages | 1038 |
Release | 2019-10-12 |
Genre | Medical |
ISBN | 0128148241 |
Maternal-Fetal and Neonatal Endocrinology: Physiology, Pathophysiology, and Clinical Management systematically examines the normal and abnormal endocrinology of the pregnant and lactating female and of the fetus and neonate. This reference volume expands coverage of specific disorders and diseases beyond the current endocrinology content on the market, which in most cases has a paragraph or no mention at all about pregnancy or aspects of fetal/neonatal development. Formalized source of maternal/fetal endocrine physiology and pathophysiology Key reference for fellows and residents for rarer endocrine pathologies Integrated presentation of new molecular and genetic causes of endocrine disorders Bridges the experience/knowledge gap of endocrinopathies rarely encountered in pregnancy
Molecular and Cellular Mechanisms in Reproduction and Early Development
Title | Molecular and Cellular Mechanisms in Reproduction and Early Development PDF eBook |
Author | Rafael A. Fissore |
Publisher | Frontiers Media SA |
Pages | 145 |
Release | 2019-08-20 |
Genre | |
ISBN | 2889459446 |
The Research Topic aims to support progress towards understanding the different sets of developmental processes that are absolutely required to complete all the steps essential for successful embryonic development, under physiological conditions. We sought contributions that dealt with single cells, interaction between cells as well as intra- and extracellular signal transduction. The Research Topic presents original studies covering experimental and theoretical approaches, descriptions of new methodologies, reviews and opinions.
Molecular Evolution of Mammalian Sex Differentiation
Title | Molecular Evolution of Mammalian Sex Differentiation PDF eBook |
Author | Wai Yee Chung |
Publisher | |
Pages | 0 |
Release | 2024* |
Genre | |
ISBN |
Englische Version: In mammals, the embryonic gonad is the only bipotential organ, differentiating into either testis or ovary during sex determination. Once specified, it produces sex-specific hormones that induce key morphological, physiological, and behavioral changes, leading to mature reproductive organs essential for species perpetuation. Despite the evolutionary importance of gonadal function, significant developmental plasticity exists across species, with underlying molecular mechanisms largely unexplored. To address this, single-cell omics techniques (scRNA- and scATAC-seq) were employed on developing gonads to investigate molecular contributors to interspecies differences during sex differentiation. Known cell types were characterized in testes and ovaries of pigs (exhibiting medullary cords), mice (lacking medullary cords), rabbits (displaying delayed meiosis of germ cells), and moles (forming ovotestes) at sexually dimorphic time points. Interspecies comparative analyses revealed both conserved and species-specific events at the levels of dynamic gene expression, co-expression networks, and cellular communication. Expression data were integrated with epigenomic data to infer gene regulatory networks (GRNs), clarifying regulatory mechanisms governing these events. Analyses revealed species-specific transcription factors in conserved GRNs and identified putative cis-regulatory elements linked with species-specific expressed genes. The study suggests diverse controls initiate meiosis in ovarian germ cells across species and that steroidogenic enzyme metabolism may contribute to unique developmental features in rabbits. Overall, this study advances the understanding of mammalian gonad differentiation and highlights how gene expression program evolution has contributed to mammalian phenotype diversity.