An easy-to-read survey of all the latest developments in molecular cardiologic research and therapy. The authors explain in a readable style the complex process of the heart's development, the molecular basis of cardiovascular diseases, and the translation of these research advances to actual clinical treatments. The expert information provided here serves as an invaluable building block for novel treatments of cardiovascular diseases and includes a comprehensive discussion of cardiac function and dysfunction, coronary artery disease, cardiac arrhythmias, vascular diseases, and risk factors for cardiovascular disease. These state-of-the-art approaches to molecular cardiologic research include critical discussion of such topics as the molecular events that regulate angiogenesis and the potential for angiogenic therapy, emerging therapies for arrhythmias, and a description of the molecular biology of aging and its impact on the cardiovascular system.

Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical departments. The text is complemented and supported by a rich variety of photomicrographs, diagrams of molecular relationships, and tables. It is uniquely useful to a wide audience of graduate students and post-doctoral fellows in areas from pathology to physiology, genetics, pharmacology, and more, as well as medical residents in pathology, laboratory medicine, internal medicine, cardiovascular surgery, and cardiology. - Explains how to identify cardiovascular pathologies and compare with normal physiology to aid research - Gives concise explanations of key issues and background reading suggestions - Covers molecular bases of diseases for better understanding of molecular events that precede or accompany the development of pathology

Molecular Cardiology for the Cardiologist, Second Edition provides a short, easily readable summary of what the new biology brings to cardiology. Special efforts have been made to include comprehensive diagrams and drawings, as well as teaching tables, and also to keep the size of the second edition within the modest limits of the first edition. The book remains divided into 5 parts. The first part is a general introduction to the new terminology. The second part is devoted to the normal structure of the heart and vessels. Parts 3 and 4 deal with physiopathology. One of the important contributions of molecular biology to cardiology is a better understanding of the general process of adaptation of the heart and vessels to a permanent mechanical overloading. Such a process is generally called remodeling, and results from coordinate changes in the expression of the genes. The last part of the book includes information on gene and cellular therapy.

Molecular Cardiology for the Cardiologist provides a short, easily readable summary of what the new biology brings to cardiology. With this in mind, special efforts have been made to present many comprehensive schemes and drawings, as well as teaching tables. The five parts of the book provide a general introduction to the new language of biology; the normal structure of the heart and blood vessels; the physiopathology and the new therapeutic avenues that have been opened up by the new biology. A concise summary of the keys that assist the cardiologist or student who seeks to learn and read more about this field. Provides practical examples to illustrate the clinical interest of the new approach.

Cardiology is an area of great recent triumphs in pharmacological and surgical treatment, yet cardiovascular disease remains the leading cause of death and disability in the industrialized world. Coronary disease, heart failure, stroke and sudden arrhythmic cardiac death challenge both medical practitioners and scientists. With the dawning of the new `molecular' era, there is an awakened hope that a more fundamental understanding of biologic processes may eventually lead to new progress in the prevention and treatment of these persistent and seemingly intransigent problems. Molecular Cardiology in Clinical Practice brings together an outstanding panel of experts in cardiovascular disease who have been at the forefront of the application of molecular medicine to cardiology. Its intent is to help bridge the gap between modern medical practice and modern science, in the belief that an understanding of basic principles can lead to new insight into the problems of cardiac patients.

The aim of Molecular Cardiology: Methods and Protocols is to document state-of-the-art molecular and genetic techniques in the area of cardiology. These modern approaches enable researchers to readily study heart diseases at the molecular level and will promote the development of new therapeutic str- egies. Methods for genetic dissection, signal transduction, and microarray analysis are excellent tools for the study of the molecular mechanisms of cardiovascular diseases. Protocols for transgenesis take advantage of recent advances in many areas of molecular and cell biology. Transgenic models of heart diseases (cardiac hypertrophy, cardiac dysfunction, and so on. ) are powerful tools for the study of heart disease pathogenesis. Methods for gene transfer to heart tissue using viral and nonviral vectors form the basis of gene therapy for heart diseases. Heart-specific promoters containing a hypox- inducible cardioprotective gene switch are key for protection of the heart from ischemia. Gene and stem cell therapies open novel and exciting avenues for the prevention and treatment of heart diseases. Molecular Cardiology: Methods and Protocols consists of 26 chapters de- ing with various aspects of molecular cardiology, including gene transfer and gene therapy for cardiovascular disease, stem cell therapy for cardiovascular disease, gene analysis in the injured and hypertrophied heart, and transgenesis in cardiovascular research. This book provides step-by-step methods for the successful completion of experimental procedures, and would be useful for both experienced and new investigators in the field of molecular cardiology.

Covering the molecular basis of heart disease, this text evaluates topics such as genetic mapping approaches in inherited cardiovascular disorders, and driving mechanisms in the transition from cardiac hypertrophy to heart failure.