Here is an essential introduction to the latest arsenal of methods available to students and practicing scientists who undertake longitudinal and other studies that collect repeated measurements for subsequent analysis. The book presents the general context of repeated measurements and introduces--through a large number of concrete examples, including data tables--the three basic types of response variables: continuous (normal), categorical and count, and duration variables. The ways in which such repeated observations are interdependent, through heterogeneity and time dependence, are discussed. The author also develops a useful framework for constructing suitable models and introduces concepts of multivariate distributions and stochastic processes necessary to appreciate the underpinnings and power of repeated measurements analyses. The book concludes with an extensive bibliography of the repeated measurement literature that will aid readers interested in finding source materials. Written by a distinguished statistician, this book is a much-needed and practical guide to the most current repeated measurements techniques available. It will be welcomed by students, applied statisticians, biostatisticians, biologists, medical researchers, econometricians, sociologists, and psychologists.

Nonlinear measurement data arise in a wide variety of biological and biomedical applications, such as longitudinal clinical trials, studies of drug kinetics and growth, and the analysis of assay and laboratory data. Nonlinear Models for Repeated Measurement Data provides the first unified development of methods and models for data of this type, with a detailed treatment of inference for the nonlinear mixed effects and its extensions. A particular strength of the book is the inclusion of several detailed case studies from the areas of population pharmacokinetics and pharmacodynamics, immunoassay and bioassay development and the analysis of growth curves.

Integrates the latest theory, methodology and applications related to the design and analysis of repeated measurement. The text covers a broad range of topics, including the analysis of repeated measures design, general crossover designs, and linear and nonlinear regression models. It also contains a 3.5 IBM compatible disk, with software to implement immediately the techniques.

Repeated Measures Design with Generalized Linear Mixed Models for Randomized Controlled Trials is the first book focused on the application of generalized linear mixed models and its related models in the statistical design and analysis of repeated measures from randomized controlled trials. The author introduces a new repeated measures design called S:T design combined with mixed models as a practical and useful framework of parallel group RCT design because of easy handling of missing data and sample size reduction. The book emphasizes practical, rather than theoretical, aspects of statistical analyses and the interpretation of results. It includes chapters in which the author describes some old-fashioned analysis designs that have been in the literature and compares the results with those obtained from the corresponding mixed models. The book will be of interest to biostatisticians, researchers, and graduate students in the medical and health sciences who are involved in clinical trials. Author Website:Data sets and programs used in the book are available at http://www.medstat.jp/downloadrepeatedcrc.html

A comprehensive introduction to a wide variety of statistical methods for the analysis of repeated measurements. It is designed to be both a useful reference for practitioners and a textbook for a graduate-level course focused on methods for the analysis of repeated measurements. The important features of this book include a comprehensive coverage of classical and recent methods for continuous and categorical outcome variables; numerous homework problems at the end of each chapter; and the extensive use of real data sets in examples and homework problems.

This book examines how individuals behave across time and to what degree that behavior changes, fluctuates, or remains stable. It features the most current methods on modeling repeated measures data as reported by a distinguished group of experts in the field. The goal is to make the latest techniques used to assess intraindividual variability accessible to a wide range of researchers. Each chapter is written in a "user-friendly" style such that even the "novice" data analyst can easily apply the techniques. Each chapter features: a minimum discussion of mathematical detail; an empirical example applying the technique; and a discussion of the software related to that technique. Content highlights include analysis of mixed, multi-level, structural equation, and categorical data models. It is ideal for researchers, professionals, and students working with repeated measures data from the social and behavioral sciences, business, or biological sciences.

Repeated measures data arise when the same characteristic is measured on each case or subject at several times or under several conditions. There is a multitude of techniques available for analysing such data and in the past this has led to some confusion. This book describes the whole spectrum of approaches, beginning with very simple and crude methods, working through intermediate techniques commonly used by consultant statisticians, and concluding with more recent and advanced methods. Those covered include multiple testing, response feature analysis, univariate analysis of variance approaches, multivariate analysis of variance approaches, regression models, two-stage line models, approaches to categorical data and techniques for analysing crossover designs. The theory is illustrated with examples, using real data brought to the authors during their work as statistical consultants.