At least one of every three Americans has used an illicit drug. Drugs attract considerable attention in science, legislation, and the media. Nonetheless, many people develop attitudes about drugs and drug users based on limited information. Researchers often find themselves divided into camps based on the drug they study most often, which limits their ability to benefit from important work done on other drugs. As a result, government policies form without a complete understanding of the intoxication experience. What is the nature of intoxication? At first, this question appears to be simple and straightforward, but upon closer inspection, the dichotomous distinctions between everyday awareness and its alternatives grow fuzzy. An in-depth examination of the subjective effects of drugs and the pursuit of altered states soon leads to age-old questions about free will, heredity, environment, and consciousness. Mind-Altering Drugs is the first book to bring together chapters from leading researchers that present diverse, empirically based insights into the subjective experiences of drugs a nd their links to addictive potential. By avoiding simple depictions of psychoactive chemicals and the people who use them, these recognized experts explain how modern research in many fields reveals a complex interaction between people, situations, and substances. Their work demonstrates that only a multitude of approaches can show the nuances of subjective experience, and that each substance may create a different effect with every administration in each user. Simple references to physiological underpinnings or positive reinforcement fail to explain the diverse responses to drugs. However, research has progressed to reveal broad, repeatable evidence that the subjective effects of substances play an important role in our understanding of drug abuse, and so should inform our decisions about policy. This thorough and accessible review of the subjective effects of drugs and the dominant theories behind those effects will provide a wealth of information about the experience of intoxication for lay readers, and a road map to studies in other disciples for student and professional researchers.

This volume brings together the latest basic and clinical research examining the effects and underlying mechanisms of psychedelic drugs. Examples of drugs within this group include LSD, psilocybin, and mescaline. Despite their structural differences, these compounds produce remarkably similar experiences in humans and share a common mechanism of action. Commonalities among the substances in this family are addressed both at the clinical and phenomenological level and at the basic neurobiological mechanism level. To the extent possible, contributions relate the clinical and preclinical findings to one another across species. The volume addresses both the risks associated with the use of these drugs and the potential medical benefits that might be associated with these and related compounds.

This fascinating book presents a scientifically objective, and thoroughly documented exposition of the pharmacological and psychological effects of nearly every known substance that affects human consciousness, from alcohol to Zopiclone. It also features first-hand accounts and descriptions of the social, cultural, and religious milieus in which many psychotropic plants are used, and discusses historical allusions to many literary and scientific figures who used or wrote of mind-altering drugs, including Freud, Dickens, Yeats, and Huxley. Intended for a wide audience of general readers seeking unbiased information, the book gives an accessible explanation of drug-receptor interaction and organic chemical structures, as well as descriptions of the discovery, isolation, and syntheses of the chemical substances responsible for drug activity. Written by an experienced chemist, the book nevertheless keeps technical information to a minimum.

First published in 1979, Psychedelic Drugs Reconsidered is regarded by many as the most comprehensive, accurate, and accessible analysis of psychedelic drugs for the general reader. It records the extensive history of scientific research on, and societal experience with, psychedelic drugs. The Lindesmith Center reprint edition features a new introduction by the authors on recent developments in psychedelic research, as well as a preface by Dr. Ethan Nadelmann, director of the Lindesmith center.

Now on Netflix as a 4-part documentary series! “Pollan keeps you turning the pages . . . cleareyed and assured.” —New York Times A #1 New York Times Bestseller, New York Times Book Review 10 Best Books of 2018, and New York Times Notable Book A brilliant and brave investigation into the medical and scientific revolution taking place around psychedelic drugs--and the spellbinding story of his own life-changing psychedelic experiences When Michael Pollan set out to research how LSD and psilocybin (the active ingredient in magic mushrooms) are being used to provide relief to people suffering from difficult-to-treat conditions such as depression, addiction and anxiety, he did not intend to write what is undoubtedly his most personal book. But upon discovering how these remarkable substances are improving the lives not only of the mentally ill but also of healthy people coming to grips with the challenges of everyday life, he decided to explore the landscape of the mind in the first person as well as the third. Thus began a singular adventure into various altered states of consciousness, along with a dive deep into both the latest brain science and the thriving underground community of psychedelic therapists. Pollan sifts the historical record to separate the truth about these mysterious drugs from the myths that have surrounded them since the 1960s, when a handful of psychedelic evangelists inadvertently catalyzed a powerful backlash against what was then a promising field of research. A unique and elegant blend of science, memoir, travel writing, history, and medicine, How to Change Your Mind is a triumph of participatory journalism. By turns dazzling and edifying, it is the gripping account of a journey to an exciting and unexpected new frontier in our understanding of the mind, the self, and our place in the world. The true subject of Pollan's "mental travelogue" is not just psychedelic drugs but also the eternal puzzle of human consciousness and how, in a world that offers us both suffering and joy, we can do our best to be fully present and find meaning in our lives.

An illustrated cultural history of drug use from its roots in animal intoxication to its future in designer neurochemicals • Featuring artwork from the upcoming High Society exhibition at the Wellcome Collection in London, one of the world’s greatest medical history collections • Explores the roles drugs play in different cultures as medicines, religious sacraments, status symbols, and coveted trade goods • Reveals how drugs drove the global trade and cultural exchange that made the modern world • Examines the causes of drug prohibitions a century ago and the current “war on drugs” Every society is a high society. Every day people drink coffee on European terraces and kava in Pacific villages; chew betel nut in Indonesian markets and coca leaf on Andean mountainsides; swallow ecstasy tablets in the clubs of Amsterdam and opium pills in the deserts of Rajastan; smoke hashish in Himalayan temples and tobacco and marijuana in every nation on earth. Exploring the spectrum of drug use throughout history--from its roots in animal intoxication to its future in designer neurochemicals--High Society paints vivid portraits of the roles drugs play in different cultures as medicines, religious sacraments, status symbols, and coveted trade goods. From the botanicals of the classical world through the mind-bending self-experiments of 18th- and 19th-century scientists to the synthetic molecules that have transformed our understanding of the brain, Mike Jay reveals how drugs such as tobacco, tea, and opium drove the global trade and cultural exchange that created the modern world and examines the forces that led to the prohibition of opium and cocaine a century ago and the “war on drugs” that rages today.

This practical guide to psychoactive drugs reveals fourteen legal and accessible paths on your journey to altered consciousness. Getting high in one form or another has been a part of human life for thousands of years. And while the US government stands in the way of this basic right, there are ways around the restrictions. With each of the fourteen psychoactive substances detailed in this book, you can get high, pass a urine drug test, and never once break the law. Legally Stoned is a practical guide to obtaining and using fourteen mind-altering agents that are both legal and easy to acquire. It also includes a description and history of each item, its chemistry and physiological reactions, accounts of its pleasures and perils, and any risks associated with it. Legally Stoned covers substances such as: • Amanita muscaria mushroom, which induces feelings of euphoria and auditory hallucinations • Anadenanthera peregrina/colubrina seeds, which have been known to cause intense visions of psychedelic light and color • Ayahuasca, which originated in South America and often produces visual hallucinations that include the jungle, exotic animals, even ancient native artwork