MicroRNA in Regenerative Medicine
Title | MicroRNA in Regenerative Medicine PDF eBook |
Author | Chandan K. Sen |
Publisher | Academic Press |
Pages | 1134 |
Release | 2023-05-08 |
Genre | Science |
ISBN | 0128207221 |
Regulating virtually all biological processes, the genome’s 2,654 newly discovered variants of mature microRNAs – short ribonucleic acid molecules found in eukaryotic cells – hold a key role in the body’s toolkit of regenerative and reparative capacities. Identifying how to activate and deliver these specialist molecules may aid in the repair and regeneration of major tissue and organ damage in future therapies. In MicroRNA and Regenerative Medicine, Second Edition, over 50 leading experts address foundational and emerging topics in the field. Concisely summarizing and evaluating key findings from new research and their translational application, contributors examine current and future significance of clinical research in the miRNA area. Coverage encompasses all major aspects of fundamental stem cell and developmental biology, including the uses of miRNA in cell and tissue plasticity, developmental biology, tissue repair, and regeneration. In particular, contributors provide focused coverage of methodologies for regenerative intervention and tissue engineering. Topics new to this edition include proteomic changes during tissue repair and regeneration, horizontal transfer of miRNAs in tissue regeneration, tissue stemness, peripheral nerve regeneration, miRNA as biomarkers, microRNA in pregnancy and embryo development, exogenous and diet derived microRNA in tissue development, ocular microRNA, mitochondrial microRNA, sensory hair cell death and regeneration, and microRNA in senescence. Features chapter contributions from international leaders in the field, covering the spectrum from bench to bedside Includes short, applied chapters offering focused discussion and practical examples Incorporates multi-color text layout with more than 150 color figures to illustrate important findings
RNAi and MicroRNA-Mediated Gene Regulation in Stem Cells
Title | RNAi and MicroRNA-Mediated Gene Regulation in Stem Cells PDF eBook |
Author | Baohong Zhang |
Publisher | Methods in Molecular Biology |
Pages | 286 |
Release | 2010-08-16 |
Genre | Medical |
ISBN |
This cutting-edge text will be a valuable resource for scientists and aspiring graduate students interested in the intersection of RNAi, miRNA, and stem cell molecular biology and exciting areas of research such as regenerative medicine and cancer.
Transcriptional and Translational Regulation of Stem Cells
Title | Transcriptional and Translational Regulation of Stem Cells PDF eBook |
Author | Gary Hime |
Publisher | Springer Science & Business Media |
Pages | 370 |
Release | 2013-05-22 |
Genre | Medical |
ISBN | 9400766211 |
This volume describes the latest findings on transcriptional and translational regulation of stem cells. Both transcriptional activators and repressors have been shown to be crucial for the maintenance of the stem cell state. A key element of stem cell maintenance is repression of differentiation factors or developmental genes – achieved transcriptionally, epigenetically by the Polycomb complex, and post-transcriptionally by RNA-binding proteins and microRNAs. This volume takes two approaches to this topic – (1) illustrating the general principles outlined above through a series of different stem cell examples – embryonic, iPS and adult stem cells, and (2) describing several molecular families that have been shown to have roles in regulation of multiple stem cell populations.
Cell Cycle Regulation
Title | Cell Cycle Regulation PDF eBook |
Author | Philipp Kaldis |
Publisher | Results and Problems in Cell Differentiation |
Pages | 400 |
Release | 2006-06-26 |
Genre | Medical |
ISBN |
This book is a state-of-the-art summary of the latest achievements in cell cycle control research with an outlook on the effect of these findings on cancer research. The chapters are written by internationally leading experts in the field. They provide an updated view on how the cell cycle is regulated in vivo, and about the involvement of cell cycle regulators in cancer.
Mesenchymal Stem Cell Derived Exosomes
Title | Mesenchymal Stem Cell Derived Exosomes PDF eBook |
Author | Yaoliang Tang |
Publisher | Academic Press |
Pages | 287 |
Release | 2015-09-02 |
Genre | Science |
ISBN | 0128004975 |
Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool. Introduces the MSC-exosome mediated cell-cell communication Covers the major functional benefits in current MSC-derived exosome studies Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies
Exosomes, Stem Cells and MicroRNA
Title | Exosomes, Stem Cells and MicroRNA PDF eBook |
Author | Karl L. Mettinger |
Publisher | Springer |
Pages | 160 |
Release | 2018-05-12 |
Genre | Science |
ISBN | 3319744704 |
This volume provides insight into the pivotal roles of stem cells, exosomes and other microvesicles in biofunction and molecular mechanisms and their therapeutic potential in translational nanomedicine. It further highlights evidence from recent studies as to how stem cell derived exosomes and microRNAs may restore and maintain tissue homeostasis, enable cells to recover critical cellular functions and begin repair regeneration. These early studies in animal models of aging also show evidence of improved immune, cardiovascular and cognitive functions as well as improved health span and life span. The use of exosomes from body fluids to define specific biomarkers for various tumors may also clear the path to patient-targeted treatments by developing exosome-derived microRNA based cancer therapeutics. It is essential reading for graduate students, research fellow and biomedical researchers in academia or the pharmaceutical or biotech industries.
Hormones, Metabolism and the Benefits of Exercise
Title | Hormones, Metabolism and the Benefits of Exercise PDF eBook |
Author | Bruce Spiegelman |
Publisher | Springer |
Pages | 108 |
Release | 2018-03-07 |
Genre | Science |
ISBN | 3319727907 |
The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism. This will include novel “myokines” that might act as new therapeutic agents in the future.