This guide to micromanipulation techniques, for assisted conception in a clinical setting, includes detailed descriptions of all common micromanipulation systems currently in use in IVF laboratories. In explaining how to optimize their successful use, the volume covers state-of-the-art techniques including ICSI, and procedures such as assisted hatching and the blastomere biopsy (for PGD). Valuable information on troubleshooting mechanical and technical difficulties is provided to help professionals ranging from technicians to consultant obstetricians master the techniques.

There are probably few people who do not dream of the good old times, when do ing science often meant fascination, excitement, even adventure. In our time, do ing science involves often technology and, perhaps, even business. But there are still niches where curiosity and fascination have their place. The subject of this book, technological as its title may sound, is one of the fortunate examples. It will report on lasers generating the coldest places in the Universe, and on table top laser microtools which can produce a heat "inferno" as it prevails in the interior of the Sun, or simulate, for specific plant cells, microgravity of the space around our plan et Earth. There will be some real surprises for the reader. The applications range from basic studies of the driving forces of cell division (and thus life) via genetic modification of cells (for example, for plant breeding) to medical applications such as blood cell analysis and finally in vitro fertilization. What are these instruments: laser microbeams and optical tweezers? Both are lasers coupled with a fluorescence microscope. The laser microbeam uses a pulsed ultraviolet laser. Light is focused, as well as possible, in space and time, in order to obtain extremely high light intensities - high enough to generate, for a very short instant, extremely hot spots which can be used to cut, fuse or perforate biological material.

In the course of the years since H. D. SCHMIDT, in 1895, describcd his "microscopic dissector," a mechanical device for dissecting and study ing biological materials, a great wealth of information has been pub lished in the scientific and technical literature on methods involving the use of exceedingly delicate microtools mechanically guided under microscopic control for the investigation of microscopic structures and very small amounts of material.. The operative tools used can be moved with considerable precision under various microscopic magnifications to perform the required tasks. With the continuous progress in these methods, hundreds of micro manipulators and other mechanical manipulativc devices, auxiliaryequip ment, and a great diversity of microtools have been described for per forming varied operations on practically any type of materials and test objects. Thus, micromanipulative and related techniques have become innumerable and often intricate, and the applications, formerly confined to certain fields of biology and medicine, have been extended to the most diverse fields of science and technology as mtn be Been from a rapid glance at the contents of the presEmt volume.

"Not everything in medical science has a clear beginning. The first realization of infertility and putative remedies remain shrouded in contextual history, but likely goes back to the dawn of our species, well before there was a written record. Childlessness was, and is still, considered a burden in some communities"--

Microrobotics is an emerging and booming area with many and various applications, including in fields such as industrial/manufacturing robotics, medical robotics, and laboratory instrumentation. Microrobotics for Micromanipulation presents for the first time, in detail, a treatment of the field of robotics dedicated to handling objects of micrometer dimensions. At these dimensions, the behavior of objects is significantly different from the better known, larger scales, which leads to implementation techniques that can be radically different from the more commonly used solutions. This book details the behaviors of objects at the micrometer scale and provides robotics solutions that are suitable, in terms of actuators, grippers, manipulators, environmental perception, and microtechnology. Worked examples are included in the book - enabling engineers, students and researchers to familiarize themselves with this emerging area and to contribute to its development.

New possibilities have recently emerged for producing optical beams with complex and intricate structures, and for the non-contact optical manipulation of matter. Structured Light and Its Applications fully describes the electromagnetic theory, optical properties, methods and applications associated with this new technology. Detailed discussions are given of unique beam characteristics, such as optical vortices and other wavefront structures, the associated phase properties and photonic aspects, along with applications ranging from cold atom manipulation to optically driven micromachines. Features include: Comprehensive and authoritative treatments of the latest research in this area of nanophotonics, written by the leading researchers Accounts of numerous microfluidics, nanofabrication, quantum informatics and optical manipulation applications Coverage that fully spans the subject area, from fundamental theory and simulations to experimental methods and results Graduate students and established researchers in academia, national laboratories and industry will find this book an invaluable guide to the latest technologies in this rapidly developing field. Comprehensive and definitive source of the latest research in nanotechnology written by the leading people in the field From theory to applications - all is presented in detail Editor is Chair of the SPIE Nanotechnology Technical Group and is leading the way in generation and manipulation of complex beams

This book provides an overview of the noteworthy developments in the field of micromachining, with a specific focus on microinjection systems used for biological micromanipulation. The author also explores the design, development, and fabrication of new mechanical designs for micromachines, with plenty of examples that elucidate their modeling and control. The design and fabrication of a piezoelectric microinjector, constant force microinjector, constant force microgripper, PDVF microforce sensor, and a piezoelectric microsyringe are presented as examples of new technology for microinjection systems. This book is appropriate for both researchers and advanced students in bioengineering.