Methods in Genomic Neuroscience
Title | Methods in Genomic Neuroscience PDF eBook |
Author | Hemin R. Chin |
Publisher | CRC Press |
Pages | 414 |
Release | 2001-09-26 |
Genre | Science |
ISBN | 100061171X |
The past few years have witnessed extraordinary advances in molecular genetic techniques and the accumulation of structural genomics information and resources in both human and model organisms. With the development of new technologies and the availability of resources like the sequence of eukaryotic genomes, problems of a previously unthinkable sco
Genomics, Circuits, and Pathways in Clinical Neuropsychiatry
Title | Genomics, Circuits, and Pathways in Clinical Neuropsychiatry PDF eBook |
Author | Thomas Lehner |
Publisher | Academic Press |
Pages | 798 |
Release | 2016-06-07 |
Genre | Science |
ISBN | 0128005300 |
This foundational work comprehensively examines the current state of the genetics, genomics and brain circuitry of psychiatric and neurological disorders. It consolidates discoveries of specific genes and genomic regions associated with these conditions, the genetic and anatomic architecture of these syndromes, and addresses how recent advances in genomics are leading to a reappraisal of the biology underlying clinical neuroscience. In doing so, it critically examines the promise and limitations of these discoveries toward treatment, and to the interdisciplinary nature of understanding brain and behavior. Coverage includes new discoveries regarding autism, epilepsy, intellectual disability, dementias, movement disorders, language impairment, disorders of attention, schizophrenia, and bipolar disorder. Genomics, Circuits, and Pathways in Clinical Neuropsychiatry focuses on key concepts, challenges, findings, and methods in genetics, genomics, molecular pathways, brain circuitry, and related neurobiology of neurologic and psychiatric disorders. - Provides interdisciplinary appeal in psychiatry, neurology, neuroscience, and genetics - Identifies key concepts, methods, and findings - Includes coverage of multiple disorders from autism to schizophrenia - Reviews specific genes associated with disorders - Discusses the genetic architecture of these syndromes - Explains how recent findings are influencing the understanding of biology - Clarifies the promise of these findings for future treatment
Guide to Research Techniques in Neuroscience
Title | Guide to Research Techniques in Neuroscience PDF eBook |
Author | Matt Carter |
Publisher | Academic Press |
Pages | 416 |
Release | 2022-03-26 |
Genre | Medical |
ISBN | 0323915612 |
Modern neuroscience research is inherently multidisciplinary, with a wide variety of cutting edge new techniques to explore multiple levels of investigation. This Third Edition of Guide to Research Techniques in Neuroscience provides a comprehensive overview of classical and cutting edge methods including their utility, limitations, and how data are presented in the literature. This book can be used as an introduction to neuroscience techniques for anyone new to the field or as a reference for any neuroscientist while reading papers or attending talks. - Nearly 200 updated full-color illustrations to clearly convey the theory and practice of neuroscience methods - Expands on techniques from previous editions and covers many new techniques including in vivo calcium imaging, fiber photometry, RNA-Seq, brain spheroids, CRISPR-Cas9 genome editing, and more - Clear, straightforward explanations of each technique for anyone new to the field - A broad scope of methods, from noninvasive brain imaging in human subjects, to electrophysiology in animal models, to recombinant DNA technology in test tubes, to transfection of neurons in cell culture - Detailed recommendations on where to find protocols and other resources for specific techniques - "Walk-through" boxes that guide readers through experiments step-by-step
Genome Editing in Neurosciences
Title | Genome Editing in Neurosciences PDF eBook |
Author | Rudolf Jaenisch |
Publisher | |
Pages | 128 |
Release | 2020-10-08 |
Genre | Medical |
ISBN | 9781013268564 |
Innovations in molecular biology are allowing neuroscientists to study the brain with unprecedented resolution, from the level of single molecules to integrated gene circuits. Chief among these innovations is the CRISPR-Cas genome editing technology, which has the precision and scalability to tackle the complexity of the brain. This Colloque Médecine et Recherche has brought together experts from around the world that are applying genome editing to address important challenges in neuroscience, including basic biology in model organisms that has the power to reveal systems-level insight into how the nervous system develops and functions as well as research focused on understanding and treating human neurological disorders. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.
Techniques for the Genetic Analysis of Brain and Behavior
Title | Techniques for the Genetic Analysis of Brain and Behavior PDF eBook |
Author | D. Goldowitz |
Publisher | Elsevier Publishing Company |
Pages | 550 |
Release | 1992 |
Genre | Medical |
ISBN |
The goal of this book is to provide a neurobehavioral context for the ever-growing list of single and multiple genes that play a role in brain structure and function. The chapters present strategies and techniques for the rigorous analysis of the genetic bases of brain and behavior, and discusses the practical and theoretical means to address these topics and provide the researcher with fine techniques for dissecting the genomic components of brain structure and behavioral function. This volume concentrates on techniques and approaches that have been largely developed with the house mouse, while providing a glimpse of genetic research with other species, such as the fruit fly, nematode worm and seaslug. Given the aim of doing genetic analysis of brain and behavior, this volume is an excellent overview of current techniques and recent innovations.
Brain Development
Title | Brain Development PDF eBook |
Author | Simon G. Sprecher |
Publisher | |
Pages | 527 |
Release | 2019 |
Genre | Animal models in research |
ISBN | 9781493997329 |
This book provides a thorough introduction to widely used techniques for the study of the intersection between developmental biology and neuroscience, an exceptional area to address and investigate impacting biological questions. The fully updated volume examines cutting-edge techniques on a representative range of animals, including widely used genetic model systems, such as the fruit fly, zebra fish, chicken, and mouse, as well as non-canonical experimental systems opened up through the advent of genome editing. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Brain Development: Methods and Protocols, Second Edition is an ideal guide for researchers interested in utilizing recent technical advances in molecular genetics for the study of the brain.
Neuroscience Methods
Title | Neuroscience Methods PDF eBook |
Author | Rosemary Martin |
Publisher | CRC Press |
Pages | 273 |
Release | 2019-08-16 |
Genre | Science |
ISBN | 1000717534 |
Unique in its coverage of such an extensive range of methods, Neuroscience Methods: A Guide for Advanced Students provides easy-to-understand descriptions of the many different techniques that are currently being used to study the brain at the molecular and cellular levels. This valuable reference text will help rescue undergraduate and postgraduate students from continuing bewilderment at the methods sections of current neuroscience publications. Topics covered include in vivo and in vitro preparations, electrophysiological, histochemical, hybridization and genetic techniques, measurement of cellular ion concentrations, methods of drug application, production of antibodies, expression systems, and neural grafting.