Methods for Studying Nucleic Acid/Drug Interactions
Title | Methods for Studying Nucleic Acid/Drug Interactions PDF eBook |
Author | Meni Wanunu |
Publisher | CRC Press |
Pages | 397 |
Release | 2016-04-19 |
Genre | Medical |
ISBN | 1439839743 |
Since most therapeutic efforts have been predominantly focused on pharmaceuticals that target proteins, there is an unmet need to develop drugs that intercept cellular pathways that critically involve nucleic acids. Progress in the discovery of nucleic acid binding drugs naturally relies on the availability of analytical methods that assess the eff
Drug-Nucleic Acid Interactions
Title | Drug-Nucleic Acid Interactions PDF eBook |
Author | |
Publisher | Elsevier |
Pages | 740 |
Release | 2001-07-31 |
Genre | Medical |
ISBN | 0080496903 |
This volume consolidates the key methods for studying ligand-nucleic acid interactions into a convenient source. Techniques that are examined range from biophysical and chemical approaches to methods rooted in molecular and cell biology.
Molecular Basis of Specificity in Nucleic Acid-Drug Interactions
Title | Molecular Basis of Specificity in Nucleic Acid-Drug Interactions PDF eBook |
Author | A. Pullman |
Publisher | Springer Science & Business Media |
Pages | 595 |
Release | 2012-12-06 |
Genre | Science |
ISBN | 9401137285 |
One of the central problems in the study of the mechanism of DNA-ligand interactions is the existence and nature of sequence specificity with respect to the base pairs of DNA. The presence of such a specificity could be of particular significance because it might possibly mean the involvement of specific genes in the effectiveness of the different drugs. The elucidation of the factors responsible for the specificity could then be important for the development of compounds susceptible to contribute to the control of gene expression and also to the development of rationally conceived, improved new generations of effective and specific chemotherapeutic agents. Important recent achievements, experimental and theoretical, in the analysis of such sequence specificities open prospects for possible rapid progress in this field. The 23rd Jerusalem symposium was devoted to the exploration of these recent achievements in relation to many types of ligand, with special emphasis on antitumor drugs. All major types of interaction, intercalation, groove binding, covalent linking, coordination, have been considered. So was also the effect of the interaction on the structure and properties of the nucleic acids and the relationship between the interaction and biological or pharmacological activities. We feel that this Volume presents a relatively complete up-to-date account of the state of the art in this important field of research.
Drug-DNA Interactions
Title | Drug-DNA Interactions PDF eBook |
Author | Kazuo Nakamoto |
Publisher | John Wiley & Sons |
Pages | 475 |
Release | 2008-09-08 |
Genre | Science |
ISBN | 0470369167 |
Learn vital information about drug-DNA interactions from Drug-DNA Interactions: Structures and Spectra, the only comprehensive book written about this topic. Understand the types of structural and bonding information that can be obtained using specific physico-chemical methods and discover how to design new drugs that are more effective than current treatments and have fewer side effects. Find detailed information about X-ray crystallography, NMR spectroscopy, molecular modeling, and optical spectroscopy such as UV-Visible absorption, fluorescence, circular dichroism (CD), flow linear dichroism (FLD), infrared (IR) and Raman spectroscopy.
Drug-DNA Interaction Protocols
Title | Drug-DNA Interaction Protocols PDF eBook |
Author | Keith R. Fox |
Publisher | Methods in Molecular Biology |
Pages | 340 |
Release | 2010 |
Genre | Medical |
ISBN |
The last few years have witnessed the creation of new generations of sequence reading compounds, which have incredible potential for targeting specific DNA sequences. In Drug-DNA Interaction Protocols, Second Edition, expert researchers explore these compounds, revealing how a deeper understanding of the structure of DNA, along with an improved ability to manipulate it, has led to much progress in recent years. Chapters describe a new arsenal of techniques for probing the interactions between drugs and DNA, including various biophysical techniques for quantifying these interactions and for describing them in molecular and atomic detail, and they comprehensively consider both molecular and cellular approaches. Composed in the highly successful Methods in Molecular BiologyTM series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Authoritative and current, Drug-DNA Interaction Protocols, Second Edition, is a critical volume that includes a wide range of chapters, which together provide methods for assessing the strength and mode of binding, the sequence selectivity, and the effect on biological systems.
Water in Biological and Chemical Processes
Title | Water in Biological and Chemical Processes PDF eBook |
Author | Biman Bagchi |
Publisher | Cambridge University Press |
Pages | 383 |
Release | 2013-11-14 |
Genre | Medical |
ISBN | 1107037298 |
A unified overview of the dynamical properties of water and its unique and diverse role in biological and chemical processes.
Workshop on Selective Gene Activation by Cell Type Specific Transcription Factors
Title | Workshop on Selective Gene Activation by Cell Type Specific Transcription Factors PDF eBook |
Author | |
Publisher | |
Pages | 91 |
Release | 1994 |
Genre | |
ISBN | 9788479195212 |