Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System
Title | Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System PDF eBook |
Author | Institute of Medicine |
Publisher | National Academies Press |
Pages | 74 |
Release | 2011-08-05 |
Genre | Medical |
ISBN | 0309212219 |
Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.
The Metabotropic Glutamate Receptors
Title | The Metabotropic Glutamate Receptors PDF eBook |
Author | P. Jeffrey Conn |
Publisher | Springer Science & Business Media |
Pages | 284 |
Release | 2013-03-09 |
Genre | Medical |
ISBN | 1475722982 |
The Metabotropic Glutamate Receptors offers state-of-the-art summaries and reviews of virtually everything known today about metabotropic glutamate receptors (mGluRs), including their molecular biology, pharmacology, anatomical distribution, and physiological and pathological roles. Illuminating the overall role played by this crucial class of receptors in brain function, the book also pinpoints those areas in which there is the greatest continuing need for focused research. Because mGluRs have the potential for participating in virtually all known functions of the central nervous system (CNS), the opportunity now exists to develop pharmacological agents that can potentially alter many brain disease processes by selective interaction with precise CNS functions. With its critical and insightful reviews, The Metabotropic Glutamate Receptors will immediately become your essential key to the development of novel treatment strategies for the widest variety of neurological disorders.
Glial ⇔ Neuronal Signaling
Title | Glial ⇔ Neuronal Signaling PDF eBook |
Author | Glenn I. Hatton |
Publisher | Springer Science & Business Media |
Pages | 460 |
Release | 2004-05-31 |
Genre | Medical |
ISBN | 9781402079368 |
Glial Neuronal Signaling fills a need for a monograph/textbook to be used in advanced courses or graduate seminars aimed at exploring glial-neuronal interactions. Even experts in the field will find useful the authoritative summaries of evidence on ion channels and transporters in glia, genes involved in signaling during development, metabolic cross talk and cooperation between astrocytes and neurons, to mention but a few of the timely summaries of a wide range of glial-neuronal interactions. The chapters are written by the top researchers in the field of glial-neuronal signaling, and cover the most current advances in this field. The book will also be of value to the workers in the field of cell biology in general. When we think about the brain we usually think about neurons. Although there are 100 billion neurons in mammalian brain, these cells do not constitute a majority. Quite the contrary, glial cells and other non-neuronal cells are 10-50 times more numerous than neurons. This book is meant to integrate the emerging body of information that has been accumulating, revealing the interactive nature of the brain's two major neural cell types, neurons and glia, in brain function.
Metabotropic Glutamate Receptors
Title | Metabotropic Glutamate Receptors PDF eBook |
Author | Andrius Baskys |
Publisher | R. G. Landes |
Pages | 110 |
Release | 1994 |
Genre | Medical |
ISBN |
Webvision
Title | Webvision PDF eBook |
Author | Helga Kolb |
Publisher | |
Pages | |
Release | 2007 |
Genre | |
ISBN |
Novel Antischizophrenia Treatments
Title | Novel Antischizophrenia Treatments PDF eBook |
Author | Mark A. Geyer |
Publisher | Springer Science & Business Media |
Pages | 456 |
Release | 2012-10-01 |
Genre | Medical |
ISBN | 3642257585 |
This volume tries to put current therapy - achievements, shortcomings, remaining medical needs - and emerging new targets into the context of increasing knowledge regarding the genetic and neurodevelopmental contributions to the pathophysiology of schizophrenia. Some of the chapters also deal with respective experimental and clinical methodology, biomarkers, and translational aspects of drug development. The volume concentrates on reviewing the ongoing research attempting to identify novel treatments for the cognitive deficits and negative symptoms of schizophrenia, which are not treated adequately by current antipsychotic medications.
mGLU Receptors
Title | mGLU Receptors PDF eBook |
Author | Richard Teke Ngomba |
Publisher | Springer |
Pages | 283 |
Release | 2017-08-22 |
Genre | Medical |
ISBN | 3319561707 |
Metabotropic glutamate receptors (mGluRs) are members of the group C family of G-protein-coupled receptors. Eight different mGlu subtypes have been identified and classified into three groups based on amino acid sequence similarity, agonist pharmacology, and the signal transduction pathways to which they couple. They perform a variety of functions in the central and peripheral nervous systems, being involved in learning, memory, anxiety, and the perception of pain. They are found in pre- and postsynaptic neurons in synapses of the hippocampus, cerebellum, and cerebral cortex, as well as other parts of the bain and peripheral tissues. This volume will focus on the latest research in the role of Group I mGluRs in health and disease.