An engaging history of the role that George Washington, Thomas Jefferson, and Benjamin Franklin played in the origins of public health in America. Before the advent of modern antibiotics, one’s life could be abruptly shattered by contagion and death, and debility from infectious diseases and epidemics was commonplace for early Americans, regardless of social status. Concerns over health affected the Founding Fathers and their families as it did slaves, merchants, immigrants, and everyone else in North America. As both victims of illness and national leaders, the Founders occupied a unique position regarding the development of public health in America. Historian Jeanne E. Abrams’s Revolutionary Medicine refocuses the study of the lives of George and Martha Washington, Benjamin Franklin, Thomas Jefferson, John and Abigail Adams, and James and Dolley Madison away from politics to the perspective of sickness, health, and medicine. For the Founders, republican ideals fostered a reciprocal connection between individual health and the “health” of the nation. Studying the encounters of these American Founders with illness and disease, as well as their viewpoints about good health, not only provides a richer and more nuanced insight into their lives, but also opens a window into the practice of medicine in the eighteenth century, which is at once intimate, personal, and first hand. Today’s American public health initiatives have their roots in the work of America’s Founders, for they recognized early on that government had compelling reasons to shoulder some new responsibilities with respect to ensuring the health and well-being of its citizenry—beginning the conversation about the country’s state of medicine and public healthcare that continues to be a work in progress.

Argues that the pace of medical discoveries has slowed in the last twenty-five years due to excessive emphasis on the social and political aspects of health care, and to controversies caused by ethical issues.

Asks whether personalised medicine is superior to 'one-size-fits-all' treatment. Does it elevate individual choice above the common good?

A professor of medicine reveals how technology like wireless internet, individual data, and personal genomics can be used to save lives.

The nature of biomedical research has been evolving in recent years. Technological advances that make it easier to study the vast complexity of biological systems have led to the initiation of projects with a larger scale and scope. In many cases, these large-scale analyses may be the most efficient and effective way to extract functional information from complex biological systems. Large-Scale Biomedical Science: Exploring Strategies for Research looks at the role of these new large-scale projects in the biomedical sciences. Though written by the National Academies' Cancer Policy Board, this book addresses implications of large-scale science extending far beyond cancer research. It also identifies obstacles to the implementation of these projects, and makes recommendations to improve the process. The ultimate goal of biomedical research is to advance knowledge and provide useful innovations to society. Determining the best and most efficient method for accomplishing that goal, however, is a continuing and evolving challenge. The recommendations presented in Large-Scale Biomedical Science are intended to facilitate a more open, inclusive, and accountable approach to large-scale biomedical research, which in turn will maximize progress in understanding and controlling human disease.

If you believe that the latest blockbuster medication is worth a premium price over your generic brand, or that doctors have access to all the information they need about a drug’s safety and effectiveness each time they write a prescription, Dr. Jerry Avorn has some sobering news. Drawing on more than twenty-five years of patient care, teaching, and research at Harvard Medical School, he shares his firsthand experience of the wide gap in our knowledge of the effectiveness of one medication as compared to another. In Powerful Medicines, he reminds us that every pill we take represents a delicate compromise between the promise of healing, the risk of side effects, and an increasingly daunting price. The stakes on each front grow higher every year as new drugs with impressive power, worrisome side effects, and troubling costs are introduced. This is a comprehensive behind-the-scenes look at issues that affect everyone: our shortage of data comparing the worth of similar drugs for the same condition; alarming lapses in the detection of lethal side effects; the underuse of life-saving medications; lavish marketing campaigns that influence what doctors prescribe; and the resulting upward spiral of costs that places vital drugs beyond the reach of many Americans. In this engagingly written book, Dr. Avorn asks questions that will interest every consumer: How can a product judged safe by the Food and Drug Administration turn out to have unexpectedly lethal side effects? Why has the nation’s drug bill been growing at nearly 20 percent per year? How can physicians and patients pick the best medication in its class? How do doctors actually make their prescribing decisions, and why do those decisions sometimes go wrong? Why do so many Americans suffer preventable illnesses and deaths that proper drug use could have averted? How can the nation gain control over its escalating drug budget without resorting to rationing or draconian governmental controls? Using clinical case histories taken from his own work as a practitioner, researcher, and advocate, Dr. Avorn demonstrates the impressive power of the well-conceived prescription as well as the debacles that can result when medications are misused. He describes an innovative program that employs the pharmaceutical industry’s own marketing techniques to reduce use of some of the most overprescribed and overpriced products. Powerful Medicines offers timely and practical advice on how the nation can improve its drug-approval process, and how patients can work with doctors to make sure their prescriptions are safe, effective, and as affordable as possible. This is a passionate and provocative call for action as well as a compelling work of clear-headed science.