Mechanisms of Chronic Liver Diseases: Identifying New Therapeutic Targets
Title | Mechanisms of Chronic Liver Diseases: Identifying New Therapeutic Targets PDF eBook |
Author | Gianfranco Danilo Alpini |
Publisher | Frontiers Media SA |
Pages | 279 |
Release | 2022-01-25 |
Genre | Medical |
ISBN | 2889741567 |
Chronic Liver Failure
Title | Chronic Liver Failure PDF eBook |
Author | Pere Ginès |
Publisher | Springer Science & Business Media |
Pages | 583 |
Release | 2010-11-03 |
Genre | Medical |
ISBN | 1607618664 |
Chronic liver failure is a frequent condition in clinical practice that encompasses all manifestations of patients with end-stage liver diseases. Chronic liver failure is a multiorgan syndrome that affects the liver, kidneys, brain, heart, lungs, adrenal glands, and vascular, coagulation, and immune systems. Chronic Liver Failure: Mechanisms and Management covers for the first time all aspects of chronic liver failure in a single book, from pathogenesis to current management. Each chapter is written by a worldwide known expert in their area and all provide the latest state-of-the-art knowledge. This volume is specifically designed to provide answers to clinical questions to all doctors dealing with patients with liver diseases, not only clinical gastroenterologists and hepatologists, but also to internists, nephrologists, intensive care physicians, and transplant surgeons.
Chronic Liver Disease: New Targets and New Mechanisms
Title | Chronic Liver Disease: New Targets and New Mechanisms PDF eBook |
Author | Jinhang Gao |
Publisher | Frontiers Media SA |
Pages | 186 |
Release | 2022-08-16 |
Genre | Science |
ISBN | 2889767760 |
Cholestatic Liver Disease
Title | Cholestatic Liver Disease PDF eBook |
Author | Elizabeth J. Carey |
Publisher | Springer |
Pages | 265 |
Release | 2014-07-18 |
Genre | Medical |
ISBN | 1493910132 |
Since the publication of the first edition, there have been advances in both the diagnosis and the management of many of the cholestatic liver diseases. Cholestatic Liver Disease, Second Edition thoroughly updates the topics previously addressed, such as primary biliary cirrhosis, primary sclerosing cholangitis and cholestatic variants of drug hepatotoxicity and viral disease. New treatments, such as the development of the farnesoid X receptor agonists for the treatment of PBC, are highlighted. Current guidelines and areas of uncertainty are also covered. Additionally, new chapters have been added to reflect the changing landscape of cholestatic liver disease. Cholestatic Liver Disease, Second Edition is a concise yet comprehensive summary of the current status of the field and is of value to clinicians and researchers interested in patients with cholestatic liver disease provide that will help to guide patient management and stimulate investigative efforts.
Stellate Cells in Health and Disease
Title | Stellate Cells in Health and Disease PDF eBook |
Author | Chandrashekhar Gandhi |
Publisher | Academic Press |
Pages | 335 |
Release | 2015-04-10 |
Genre | Science |
ISBN | 0128005440 |
Stellate Cells in Health and Disease is a comprehensive reference providing the most up-to-date knowledge and perspectives on the function of stellate cells affecting the liver and other organs. The text presents comprehensive coverage of their already established role in hepatic fibrosis along with the newer emerging evidence for stellate cell participation in the liver cell (hepatocyte) survival and regeneration, hepatic immunobiology, transplant tolerance, and liver cancer. Chapters describe both animal and human research and the relevance of findings from animal research to human pathophysiology, and also contain sections on future directions which will be of special interest to basic and clinical researchers working on liver fibrosis, hepatic biology, and pathobiology. - Presents coverage of the mechanisms of liver fibrosis with stellate cells as a target for therapy. - Shows stellate cells as a major participant in hepatic immunobiology, including transplantation immunology. - Key illustrations show the phenotypical changes in stellate cells in situ and tissue culture, their interactions with other cell types, signaling pathways and demonstrate the functions and roles of stellate cell in pathological processes.
Biomarkers in Liver Disease
Title | Biomarkers in Liver Disease PDF eBook |
Author | Victor R. Preedy |
Publisher | Springer |
Pages | 0 |
Release | 2017-07-14 |
Genre | Medical |
ISBN | 9789400776746 |
In the past decade there has been a major sea change in the way disease is diagnosed and investigated due to the advent of high throughput technologies, such as microarrays, lab on a chip, proteomics, genomics, lipomics, metabolomics etc. These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. In many instances these developments have gone hand in hand with the discovery of biomarkers elucidated via traditional or conventional methods, such as histopathology or clinical biochemistry. Together with microprocessor-based data analysis, advanced statistics and bioinformatics these markers have been used to identify individuals with active disease or pathology as well as those who are refractory or have distinguishing pathologies. New analytical methods that have been used to identify markers of disease and is suggested that there may be as many as 40 different platforms. Unfortunately techniques and methods have not been readily transferable to other disease states and sometimes diagnosis still relies on single analytes rather than a cohort of markers. There is thus a demand for a comprehensive and focused evidenced-based text and scientific literature that addresses these issues. Hence the formulation of Biomarkers in Disease The series covers a wide number of areas including for example, nutrition, cancer, endocrinology, cardiology, addictions, immunology, birth defects, genetics, and so on. The chapters are written by national or international experts and specialists.
Drug-Induced Liver Injury
Title | Drug-Induced Liver Injury PDF eBook |
Author | |
Publisher | Academic Press |
Pages | 290 |
Release | 2019-07-13 |
Genre | Medical |
ISBN | 0128173173 |
Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series