This thesis presents the first measurement of charmed D0 meson production relative to the reaction plane in Pb–Pb collisions at the center-of-mass energy per nucleon-nucleon collision of √sNN = 2.76 TeV. It also showcases the measurement of the D0 production in p–Pb collisions at √sNN = 5.02 TeV with the ALICE detector at the CERN Large Hadron Collider. The measurement of the D0 azimuthal anisotropy with respect to the reaction plane indicates that low- momentum charm quarks participate in the collective expansion of the high-density, strongly interacting medium formed in ultra-relativistic heavy-ion collisions, despite their large mass. This behavior can be explained by charm hadronization via recombination with light quarks from the medium and collisional energy loss. The measurement of the D0 production in p–Pb collisions is crucial to separate the effect induced by cold nuclear matter from the final- state effects induced by the hot medium formed in Pb–Pb collisions. The D0 production in p–Pb collisions is consistent with the binary collision scaling of the production in pp collisions, demonstrating that the modification of the momentum distribution observed in Pb–Pb collisions with respect to pp is predominantly induced by final-state effects such as the charm energy loss.

This thesis provides a comprehensive view of the physics of charmed hadrons in high-energy proton-proton and heavy-ion collisions. Given their large masses, charm quarks are produced in the early stage of a heavy-ion collision and they subsequently experience the full system evolution probing the colour-deconfined medium called quark-gluon plasma (QGP) created in such collisions. In this thesis, the mechanisms of charm-quark in-medium energy loss and hadronisation are discussed via the measurements of the production of charm mesons with (Ds+) and without (D+) strange-quark content in different colliding systems, using data collected by the ALICE experiment at the CERN LHC. The participation of the charm quark and its possible thermalisation in the QGP are studied via measurements of azimuthal anisotropies in the production of D+ mesons. Finally, the prospects for future measurements with the upgraded ALICE experimental apparatus and with more refined machine learning techniques are presented.

This book focuses on new experimental and theoretical advances concerning the role of strange and heavy-flavour quarks in high-energy heavy-ion collisions and in astrophysical phenomena. The topics covered include • Strangeness and heavy-quark production in nuclear collisions and hadronic interactions, • Hadron resonances in the strongly-coupled partonic and hadronic medium, • Bulk matter phenomena associated with strange and heavy quarks, • QCD phase structure, • Collectivity in small systems, • Strangeness in astrophysics,• Open questions and new developments.

This book highlights the discussions by renown researchers on questions emerged during transition from the relativistic heavy-ion collider (RHIC) to the future electron ion collider (EIC). Over the past two decades, the RHIC has provided a vast amount of data over a wide range of the center of mass energies. What are the scientific priorities, after RHIC is shut down and turned to the future EIC? What should be the future focuses of the high-energy nuclear collisions? What are thermodynamic properties of quantum chromodynamics (QCD) at large baryon density? Where is the phase boundary between quark-gluon-plasma and hadronic matter at high baryon density? How does one make connections from thermodynamics learned in high-energy nuclear collisions to astrophysical topics, to name few, the inner structure of compact stars, and perhaps more interestingly, the dynamical processes of the merging of neutron stars? While most particle physicists are interested in Dark Matter, we should focus on the issues of Visible Matter! Multiple heavy-ion accelerator complexes are under construction: NICA at JINR (4 ~ 11 GeV), FAIR at GSI (2 ~ 4.9 GeV SIS100), HIAF at IMP (2 ~ 4 GeV). In addition, the heavy-ion collision has been actively discussed at the J-PARC. The book is a collective work of top researchers from the field where some of the above-mentioned basic questions will be addressed. We believe that answering those questions will certainly advance our understanding of the phase transition in early universe as well as its evolution that leads to today's world of nature.

This book focuses on new experimental and theoretical advances concerning the role of strange and heavy-flavour quarks in high-energy heavy-ion collisions and in astrophysical phenomena. The topics covered include • Strangeness and heavy-quark production in nuclear collisions and hadronic interactions, • Hadron resonances in the strongly-coupled partonic and hadronic medium, • Bulk matter phenomena associated with strange and heavy quarks, • QCD phase structure, • Collectivity in small systems, • Strangeness in astrophysics,• Open questions and new developments.

The Large Hadron Collider (LHC) is the highest energy collider ever built. It resides near Geneva in a tunnel 3.8m wide, with a circumference of 26.7km, which was excavated in 1983-1988 to initially house the electron-positron collider LEP. The LHC was approved in 1995, and it took until 2010 for reliable operation. By now, a larger set of larger integrated luminosities have been accumulated for physics analyses in the four collider experiments: ATLAS, CMS, LHCb and ALICE.The LHC operates with an extended cryogenic plant, using a multi-stage injection system comprising the PS and SPS accelerators (still in use for particle physics experiments at lower energies). The beams are guided by 1232 superconducting high field dipole magnets.Intense works are underway in preparation of the High Luminosity LHC, aimed at upgrading the LHC and detectors for collecting ten times more luminosity, and extending the collider life to the early 2040's. So far, the (HL-)LHC project represents a cumulation of around one hundred thousand person-years of innovative work by technicians, engineers, and physicists from all over the world; probably the largest scientific effort ever in the history of humanity. The book is driven by the realisation of the unique value of this accelerator complex and by the recognition of the status of high energy physics, described by a Standard Model — which still leaves too many questions unanswered to be the appropriate theory of elementary particles and their interactions.Following the Introduction are: three chapters which focus on the initial decade of operation, leading to the celebrated discovery of the Higgs Boson, on the techniques and physics of the luminosity upgrade, and finally on major options - of using the LHC in a concurrent, power economic, electron-hadron scattering mode, when upgraded to higher energies or eventually as an injector for the next big machine. The various technical and physics chapters, provided by 61 authors, characterise the fascinating opportunities the LHC offers for the next two decades ahead (possibly longer), with the goal to substantially advance our understanding of nature.