This book discusses the theories, methods, and application techniques of the measurement data mathematical modeling and parameter estimation. It seeks to build a bridge between mathematical theory and engineering practice in the measurement data processing field so theoretical researchers and technical engineers can communicate. It is organized with abundant materials, such as illustrations, tables, examples, and exercises. The authors create examples to apply mathematical theory innovatively to measurement and control engineering. Not only does this reference provide theoretical knowledge, it provides information on first hand experiences.

This book presents a detailed examination of the estimation techniques and modeling problems. The theory is furnished with several illustrations and computer programs to promote better understanding of system modeling and parameter estimation.

This book provide a comprehensive set of modeling methods for data and uncertainty analysis, taking readers beyond mainstream methods and focusing on techniques with a broad range of real-world applications. The book will be useful as a textbook for graduate students, or as a training manual in the fields of calibration and testing. The work may also serve as a reference for metrologists, mathematicians, statisticians, software engineers, chemists, and other practitioners with a general interest in measurement science.

Models of dynamical systems are required for various purposes in the field of systems and control. The models are handled either in discrete time (DT) or in continuous time (CT). Physical systems give rise to models only in CT because they are based on physical laws which are invariably in CT. In system identification, indirect methods provide DT models which are then converted into CT. Methods of directly identifying CT models are preferred to the indirect methods for various reasons. The direct methods involve a primary stage of signal processing, followed by a secondary stage of parameter estimation. In the primary stage, the measured signals are processed by a general linear dynamic operation—computational or realized through prefilters, to preserve the system parameters in their native CT form—and the literature is rich on this aspect. In this book: Identification of Continuous-Time Systems-Linear and Robust Parameter Estimation, Allamaraju Subrahmanyam and Ganti Prasada Rao consider CT system models that are linear in their unknown parameters and propose robust methods of estimation. This book complements the existing literature on the identification of CT systems by enhancing the secondary stage through linear and robust estimation. In this book, the authors provide an overview of CT system identification, consider Markov-parameter models and time-moment models as simple linear-in-parameters models for CT system identification, bring them into mainstream model parameterization via basis functions, present a methodology to robustify the recursive least squares algorithm for parameter estimation of linear regression models, suggest a simple off-line error quantification scheme to show that it is possible to quantify error even in the absence of informative priors, and indicate some directions for further research. This modest volume is intended to be a useful addition to the literature on identifying CT systems.

This judicious selection of articles combines mathematical and numerical methods to apply parameter estimation and optimum experimental design in a range of contexts. These include fields as diverse as biology, medicine, chemistry, environmental physics, image processing and computer vision. The material chosen was presented at a multidisciplinary workshop on parameter estimation held in 2009 in Heidelberg. The contributions show how indispensable efficient methods of applied mathematics and computer-based modeling can be to enhancing the quality of interdisciplinary research. The use of scientific computing to model, simulate, and optimize complex processes has become a standard methodology in many scientific fields, as well as in industry. Demonstrating that the use of state-of-the-art optimization techniques in a number of research areas has much potential for improvement, this book provides advanced numerical methods and the very latest results for the applications under consideration.

Classification, Parameter Estimation and State Estimation is a practical guide for data analysts and designers of measurement systems and postgraduates students that are interested in advanced measurement systems using MATLAB. 'Prtools' is a powerful MATLAB toolbox for pattern recognition and is written and owned by one of the co-authors, B. Duin of the Delft University of Technology. After an introductory chapter, the book provides the theoretical construction for classification, estimation and state estimation. The book also deals with the skills required to bring the theoretical concepts to practical systems, and how to evaluate these systems. Together with the many examples in the chapters, the book is accompanied by a MATLAB toolbox for pattern recognition and classification. The appendix provides the necessary documentation for this toolbox as well as an overview of the most useful functions from these toolboxes. With its integrated and unified approach to classification, parameter estimation and state estimation, this book is a suitable practical supplement in existing university courses in pattern classification, optimal estimation and data analysis. Covers all contemporary main methods for classification and estimation. Integrated approach to classification, parameter estimation and state estimation Highlights the practical deployment of theoretical issues. Provides a concise and practical approach supported by MATLAB toolbox. Offers exercises at the end of each chapter and numerous worked out examples. PRtools toolbox (MATLAB) and code of worked out examples available from the internet Many examples showing implementations in MATLAB Enables students to practice their skills using a MATLAB environment

Most of the modeling performed in biology aims at achieving a quantitative description and understanding of the intracellular signaling pathways within a "typical cell". However, in many biologically important situations even genetically identical cell populations show a heterogeneous response. This means that individual members of the cell population behave differently. Such situations require the study of cell-to-cell variability and the development of models for heterogeneous cell populations. The main contribution of this thesis is the development of unifying modeling frameworks for signal transduction and proliferation processes in heterogeneous cell populations. These modeling frameworks allow for the detailed description of individual cells as well as differences between them. In contrast to many existing modeling approaches, the proposed frameworks allow for a direct comparison of model predictions with available data. Beyond this, the proposed population models can be simulated efficiently and, by exploiting the model structures, we are able to develop model-tailored Bayesian parameter estimation methods. These methods enable the calculation of the optimal parameter estimates, as well as the evaluation of the parameter and prediction uncertainties. The proposed tools allow for novel insights in population dynamics, in particular the model-based characterization of population heterogeneity and cellular subgroups. This is illustrated for two different application examples: pro- and anti-apoptotic signaling, which is interesting in the context of cancer therapy, and immune cell proliferation.