Approach your problems from the right end It isn't that they can't see the solution. It is and begin with the answers. Then one day, that they can't see the problem. perhaps you will find the final question. G. K. Chesterton. The Scandal of Father 'The Hermit Clad in Crane Feathers' in R. Brown 'The point of a Pin'. van Gulik's The Chinese Maze Murders. Growing specialization and diversification have brought a host of monographs and textbooks on increasingly specialized topics. However, the "tree" of knowledge of mathematics and related fields does not grow only by putting forth new branches. It also happens, quite often in fact, that branches which were thought to be completely disparate are suddenly seen to be related. Further, the kind and level of sophistication of mathematics applied in various sciences has changed drastically in recent years: measure theory is used (non trivially) in regional and theoretical economics; algebraic geometry interacts with physics; the Minkowsky lemma, coding theory and the structure of water meet one another in packing and covering theory; quantum fields, crystal defects and mathematical programming profit from homotopy theory; Lie algebras are relevant to filtering; and prediction and electrical engineering can use Stein spaces. And in addition to this there are such new emerging subdisciplines as "experimental mathematics", "CFD", "completely integrable systems", "chaos, synergetics and large-scale order", which are almost impossible to fit into the existing classification schemes. They draw upon widely different sections of mathematics.

This book is intended for medical students and advanced undergraduates such as physicists and mathematicians with inter-disciplinary interests, biophysicists, medical physicists, applied mathematicians and others who wish to understand medicine in mathematical terms as well as current mathematical applications in physiology and medicine. The mathematical presentation is clear and self-contained.This book, representing 15 years of work at RAND Corporation and USC on chemotherapy, pharmacokinetics and nuclear medicine, attempts to direct medical scientists towards mathematical aspects of problems in medicine. The book begins with an introduction to compartmental models and matrix theory, highlighting the advantages of the approach. Discussions on how questions in observations and testing lead to multi-point boundary value problems are presented. The potentials of the digital computer in the bio-medical field are examined. A new approach — dynamic programming — to overcome clinical constraints is covered in detail. The reader should obtain a broad impression of where future research opportunities in the biochemical field lie.

The result of lectures given by the authors at New York University, the University of Utah, and Michigan State University, the material is written for students who have had only one term of calculus, but it contains material that can be used in modeling courses in applied mathematics at all levels through early graduate courses. Numerous exercises are given as well as solutions to selected exercises, so as to lead readers to discover interesting extensions of that material. Throughout, illustrations depict physiological processes, population biology phenomena, corresponding models, and the results of computer simulations. Topics covered range from population phenomena to demographics, genetics, epidemics and dispersal; in physiological processes, including the circulation, gas exchange in the lungs, control of cell volume, the renal counter-current multiplier mechanism, and muscle mechanics; to mechanisms of neural control. Each chapter is graded in difficulty, so a reading of the first parts of each provides an elementary introduction to the processes and their models.

Mathematical Methods in Medical and Biological Sciences presents mathematical methods for computational models arising in the medical and biological sciences. The book presents several real-life medical and biological models, such as infectious and non-infectious diseases that can be modeled mathematically to accomplish profound research in virtual environments when the cost of laboratory expenses is relatively high. It focuses on mathematical techniques that provide global solutions for models arising in medical and biological sciences by considering their long-term benefits. In addition, the book provides leading-edge developments and insights for a range of applications, including epidemiological modeling of pandemic dynamics, viral infection developments, cancer developments, blood oxygen dynamics, HIV infection spread, reaction-diffusion models, polio infection spread, and chaos modeling with fractional order derivatives. - Presents the mathematical treatment of a wide range of real-life medical and biological models, including both infectious and non-infectious diseases - Provides in-depth analysis of the spread of Covid-19, polio, and HIV, including discussion of computational methods and applications - Includes computational modeling methods, along with their practical applications, providing the basis for further exploration and research in epidemiology and applied biomedical sciences

Quantitative biomedical data analysis is a fast-growing interdisciplinary area of applied and computational mathematics, statistics, computer science, and biomedical science, leading to new fields such as bioinformatics, biomathematics, and biostatistics. In addition to traditional statistical techniques and mathematical models using differential equations, new developments with a very broad spectrum of applications, such as wavelets, spline functions, curve and surface subdivisions, sampling, and learning theory, have found their mathematical home in biomedical data analysis.This book gives a new and integrated introduction to quantitative medical data analysis from the viewpoint of biomathematicians, biostatisticians, and bioinformaticians. It offers a definitive resource to bridge the disciplines of mathematics, statistics, and biomedical sciences. Topics include mathematical models for cancer invasion and clinical sciences, data mining techniques and subset selection in data analysis, survival data analysis and survival models for cancer patients, statistical analysis and neural network techniques for genomic and proteomic data analysis, wavelet and spline applications for mass spectrometry data preprocessing and statistical computing.

Mathematical biomedicine is a rapidly developing interdisciplinary field of research that connects the natural and exact sciences in an attempt to respond to the modeling and simulation challenges raised by biology and medicine. There exist a large number of mathematical methods and procedures that can be brought in to meet these challenges and this book presents a palette of such tools ranging from discrete cellular automata to cell population based models described by ordinary differential equations to nonlinear partial differential equations representing complex time- and space-dependent continuous processes. Both stochastic and deterministic methods are employed to analyze biological phenomena in various temporal and spatial settings. This book illustrates the breadth and depth of research opportunities that exist in the general field of mathematical biomedicine by highlighting some of the fascinating interactions that continue to develop between the mathematical and biomedical sciences. It consists of five parts that can be read independently, but are arranged to give the reader a broader picture of specific research topics and the mathematical tools that are being applied in its modeling and analysis. The main areas covered include immune system modeling, blood vessel dynamics, cancer modeling and treatment, and epidemiology. The chapters address topics that are at the forefront of current biomedical research such as cancer stem cells, immunodominance and viral epitopes, aggressive forms of brain cancer, or gene therapy. The presentations highlight how mathematical modeling can enhance biomedical understanding and will be of interest to both the mathematical and the biomedical communities including researchers already working in the field as well as those who might consider entering it. Much of the material is presented in a way that gives graduate students and young researchers a starting point for their own work.