VLSI Electronics: Microstructure Science, Volume 6: Materials and Process Characterization addresses the problem of how to apply a broad range of sophisticated materials characterization tools to materials and processes used for development and production of very large scale integration (VLSI) electronics. This book discusses the various characterization techniques, such as Auger spectroscopy, secondary ion mass spectroscopy, X-ray topography, transmission electron microscopy, and spreading resistance. The systematic approach to the technologies of VLSI electronic materials and device manufacture are also considered. This volume is beneficial to materials scientists, chemists, and engineers who are commissioned with the responsibility of developing and implementing the production of materials and devices to support the VLSI era.

The proceedings of ALTECH 2009 address recent developments and applications of analytical techniques for semiconductor materials, processes and devices. The papers comprise techniques of elemental and structural analysis for bulk and surface impurities and defects, thin films as well as dopants in ultra-shallow junctions.

Industrial Chemical Process Analysis and Design uses chemical engineering principles to explain the transformation of basic raw materials into major chemical products. The book discusses traditional processes to create products like nitric acid, sulphuric acid, ammonia, and methanol, as well as more novel products like bioethanol and biodiesel. Historical perspectives show how current chemical processes have developed over years or even decades to improve their yields, from the discovery of the chemical reaction or physico-chemical principle to the industrial process needed to yield commercial quantities. Starting with an introduction to process design, optimization, and safety, Martin then provides stand-alone chapters—in a case study fashion—for commercially important chemical production processes. Computational software tools like MATLAB®, Excel, and Chemcad are used throughout to aid process analysis. - Integrates principles of chemical engineering, unit operations, and chemical reactor engineering to understand process synthesis and analysis - Combines traditional computation and modern software tools to compare different solutions for the same problem - Includes historical perspectives and traces the improving efficiencies of commercially important chemical production processes - Features worked examples and end-of-chapter problems with solutions to show the application of concepts discussed in the text

Process Validation in Manufacturing of Biopharmaceuticals, Third Edition delves into the key aspects and current practices of process validation. It includes discussion on the final version of the FDA 2011 Guidance for Industry on Process Validation Principles and Practices, commonly referred to as the Process Validation Guidance or PVG, issued in final form on January 24, 2011. The book also provides guidelines and current practices, as well as industrial case studies illustrating the different approaches that can be taken for successful validation of biopharmaceutical processes. Case studies include Process validation for membrane chromatography Leveraging multivariate analysis tools to qualify scale-down models A matrix approach for process validation of a multivalent bacterial vaccine Purification validation for a therapeutic monoclonal antibody expressed and secreted by Chinese Hamster Ovary (CHO) cells Viral clearance validation studies for a product produced in a human cell line A much-needed resource, this book presents process characterization techniques for scaling down unit operations in biopharmaceutical manufacturing, including chromatography, chemical modification reactions, ultrafiltration, and microfiltration. It also provides practical methods to test raw materials and in-process samples. Stressing the importance of taking a risk-based approach towards computerized system compliance, this book will help you and your team ascertain process validation is carried out and exceeds expectations.

This book starts with an extended introductory treatise on the fundamentals before moving on to a detailed description of the new methods of purification of transition metals and rare earth metals.

Manufacturing, reduced to its simplest form, involves the sequencing of product forms through a number of different processes. Each individual step, known as an unit manufacturing process, can be viewed as the fundamental building block of a nation's manufacturing capability. A committee of the National Research Council has prepared a report to help define national priorities for research in unit processes. It contains an organizing framework for unit process families, criteria for determining the criticality of a process or manufacturing technology, examples of research opportunities, and a prioritized list of enabling technologies that can lead to the manufacture of products of superior quality at competitive costs. The study was performed under the sponsorship of the National Science Foundation and the Defense Department's Manufacturing Technology Program.