Wexler tells the story of a family at risk for Huntington's disease, a hereditary, incurable, fatal disorder from which her own mother died. This graceful and eloquent account goes beyond the specifics of the disease to explore the dynamics of family secrets, of living at risk, and the drama and limits of biomedical research. Photos.

Once a thriving metropolis on the banks of the Mississippi, St. Louis, Missouri, is now a ghostly landscape of vacant houses, boarded-up storefronts, and abandoned factories. The Gateway City is, by any measure, one of the most depopulated, deindustrialized, and deeply segregated examples of American urban decay. "Not a typical city," as one observer noted in the late 1970s, "but, like a Eugene O'Neill play, it shows a general condition in a stark and dramatic form." Mapping Decline examines the causes and consequences of St. Louis's urban crisis. It traces the complicity of private real estate restrictions, local planning and zoning, and federal housing policies in the "white flight" of people and wealth from the central city. And it traces the inadequacy—and often sheer folly—of a generation of urban renewal, in which even programs and resources aimed at eradicating blight in the city ended up encouraging flight to the suburbs. The urban crisis, as this study of St. Louis makes clear, is not just a consequence of economic and demographic change; it is also the most profound political failure of our recent history. Mapping Decline is the first history of a modern American city to combine extensive local archival research with the latest geographic information system (GIS) digital mapping techniques. More than 75 full-color maps—rendered from census data, archival sources, case law, and local planning and property records—illustrate, in often stark and dramatic ways, the still-unfolding political history of our neglected cities.

NEW YORK TIMES BESTSELLER • In this “ambitious and challenging” (The New York Review of Books) work, the bestselling author of Monsoon and Balkan Ghosts offers a revelatory prism through which to view global upheavals and to understand what lies ahead for continents and countries around the world. In The Revenge of Geography, Robert D. Kaplan builds on the insights, discoveries, and theories of great geographers and geopolitical thinkers of the near and distant past to look back at critical pivots in history and then to look forward at the evolving global scene. Kaplan traces the history of the world’s hot spots by examining their climates, topographies, and proximities to other embattled lands. The Russian steppe’s pitiless climate and limited vegetation bred hard and cruel men bent on destruction, for example, while Nazi geopoliticians distorted geopolitics entirely, calculating that space on the globe used by the British Empire and the Soviet Union could be swallowed by a greater German homeland. Kaplan then applies the lessons learned to the present crises in Europe, Russia, China, the Indian subcontinent, Turkey, Iran, and the Arab Middle East. The result is a holistic interpretation of the next cycle of conflict throughout Eurasia. Remarkably, the future can be understood in the context of temperature, land allotment, and other physical certainties: China, able to feed only 23 percent of its people from land that is only 7 percent arable, has sought energy, minerals, and metals from such brutal regimes as Burma, Iran, and Zimbabwe, putting it in moral conflict with the United States. Afghanistan’s porous borders will keep it the principal invasion route into India, and a vital rear base for Pakistan, India’s main enemy. Iran will exploit the advantage of being the only country that straddles both energy-producing areas of the Persian Gulf and the Caspian Sea. Finally, Kaplan posits that the United States might rue engaging in far-flung conflicts with Iraq and Afghanistan rather than tending to its direct neighbor Mexico, which is on the verge of becoming a semifailed state due to drug cartel carnage. A brilliant rebuttal to thinkers who suggest that globalism will trump geography, this indispensable work shows how timeless truths and natural facts can help prevent this century’s looming cataclysms.

Wexler tells the story of a family at risk for Huntington's disease, a hereditary, incurable, fatal disorder from which her own mother died. This graceful and eloquent account goes beyond the specifics of the disease to explore the dynamics of family secrets, of living at risk, and the drama and limits of biomedical research. Photos.

How tiny variations in our personal DNA can determine how we look, how we behave, how we get sick, and how we get well. News stories report almost daily on the remarkable progress scientists are making in unraveling the genetic basis of disease and behavior. Meanwhile, new technologies are rapidly reducing the cost of reading someone's personal DNA (all six billion letters of it). Within the next ten years, hospitals may present parents with their newborn's complete DNA code along with her footprints and APGAR score. In Genetic Twists of Fate, distinguished geneticists Stanley Fields and Mark Johnston help us make sense of the genetic revolution that is upon us. Fields and Johnston tell real life stories that hinge on the inheritance of one tiny change rather than another in an individual's DNA: a mother wrongly accused of poisoning her young son when the true killer was a genetic disorder; the screen siren who could no longer remember her lines because of Alzheimer's disease; and the president who was treated with rat poison to prevent another heart attack. In an engaging and accessible style, Fields and Johnston explain what our personal DNA code is, how a few differences in its long list of DNA letters makes each of us unique, and how that code influences our appearance, our behavior, and our risk for such common diseases as diabetes or cancer.

Sixteen-year-old Avery West continues her journey across Europe with Jack and Stellan, following clues that she hopes will lead to Alexander the Great's tomb and the secret it holds.

This book represents the first comprehensive reference volume available on subsurface transport and fate processes. The volume is organized into four sections covering the basics of contaminant properties and how they affect transport and fate, the fundamental processes affecting subsurface transport and fate of contaminants, applications of transport and fate information to various contaminant types, and utilization of transport and fate information for predicting contaminant behavior. Specific topics such as traditional hydrodynamic processes of advection and dispersion, facilitated transport and contaminant flushing, and individual ground water contaminants are also explored in detail. Subsurface Transport and Fate Processes is ideal for environmental and ground water consultants, regulatory agency personnel, and educators in geology, hydrogeology, civil engineering, and environmental engineering.