Management of Hereditary Colorectal Cancer
Title | Management of Hereditary Colorectal Cancer PDF eBook |
Author | Jose G. Guillem |
Publisher | Springer Nature |
Pages | 213 |
Release | 2020-04-02 |
Genre | Medical |
ISBN | 3030262340 |
This book provides a comprehensive review of the clinical management of hereditary colorectal cancer. The text focuses on six distinct patient groups: patients with early age-of-onset colorectal cancer and adenomas, patients with hamartomatous colorectal polyps, patients afflicted with familial adenomatous polyposis (FAP), patients with attenuated familial adenomatous polyposis (AFAP), patients with MYH associated polyposis (MAP), and patients afflicted with lynch syndrome (LS). Each chapter illustrates how clinicians utilize current technologies in genetic testing, pathological review, and endoscopic, surgical, and chemotherapeutic/immunotherapeutic approaches to manage these patient groups. Topics such as the timing of genetic testing, endoscopic screening and surveillance, prophylactic surgical options and chemo-preventive interventions are also discussed in concise yet precise detail. Written by experts in their fields, Management of Hereditary Colorectal Cancer: A Multidisciplinary Approach is a valuable and timely resource for gastroenterologists, surgeons, genetic counselors, medical oncologists, psychologists, and any health caregivers involved with the management of patients and families afflicted with a hereditary form of colorectal cancer.
Hereditary Colorectal Cancer
Title | Hereditary Colorectal Cancer PDF eBook |
Author | Miguel A. Rodriguez-Bigas |
Publisher | Springer Science & Business Media |
Pages | 615 |
Release | 2010-09-10 |
Genre | Medical |
ISBN | 144196603X |
Colorectal cancer is the third most commonly diagnosed cancer in the US and the third most recently linked to cancer deaths. The national annual incidence rate of colorectal cancer is approximately 148,000+, striking slightly more females than males. The lifetime risk of colorectal cancer is 5-6%, however patients with a familial risk (with two or more first or second degree relatives) make up 20% of the patients. Persons who carry genetic mutations linked to hereditary colorectal cancer are the most likely to develop the disease.
Hereditary Colorectal Cancer
Title | Hereditary Colorectal Cancer PDF eBook |
Author | Laura Valle |
Publisher | Springer |
Pages | 494 |
Release | 2018-05-04 |
Genre | Medical |
ISBN | 3319742590 |
This book provides information on a wide variety of issues ranging from genetics to clinical description of the syndromes, genetic testing and counseling, and clinical management including surveillance, surgical and prophylactic interventions, and chemoprevention. Moreover, current hot issues, such as the identification of novel causal genes and the challenges we face, and the relevance of cancer risk modifiers, both genetic and environmental, are also discussed. This reference book is great for geneticists, oncologists, genetic counselors, researchers, clinicians, surgeons and nurses dedicated to, or interested in, hereditary cancer. The best and most recognized experts in the field have contributed to this project, guaranteeing updated information, accuracy and the discussion of topical issues.
Hereditary Colorectal Cancer
Title | Hereditary Colorectal Cancer PDF eBook |
Author | Joji Utsunomiya |
Publisher | Springer Science & Business Media |
Pages | 564 |
Release | 2013-11-27 |
Genre | Medical |
ISBN | 4431683372 |
Since the success in chemical induction of cancer in rabbit's ear skin by K. Yamagiwa in 1915, oncologists of the world have come to believe that they can only solve their problems by means of animal experimen tation. The importance of environmental factors became moreevident in 1935 when T. Yoshida and T. Sasaki introduced azodye hepatocarcino genesis in rats. In the domain of the gastrointestinal tract, T. Sugimura has more recently accumulated enough evidence to indicate that locally active chemical mutagens are carcinogenic. In contrast, principal approaches to colorectal tumors have been quite different: emphasis has been placed on gene identification. Long before cancer of the large bowel was recognized, importance of the roles of adenomatosis coli and its familial occurrence attracted the attention of epidemiologists and geneticists. Morphological characteri zation and analysis of hereditary trends of human material have already bad a long history, and recently detailed analysis of genetic material has become feasible in the wake of rapid development in our knowledge of the oncoviruses, oncogenes, suppressor genes, chromosomal and DNA mapping, molecular mutation and so on. lt is true that in colorectal pathology, and in no other field, these areas of research have been explored more extensively and decisively. The identification of previ ously ill-defined lesions such as precancers and benign neoplasms have been improved because sequential changes can be observed in multiple samples spread over a wide area and followed up in due course.
Genetics of Colorectal Cancer
Title | Genetics of Colorectal Cancer PDF eBook |
Author | John D. Potter |
Publisher | Springer |
Pages | 309 |
Release | 2008-12-08 |
Genre | Medical |
ISBN | 9780387095677 |
Genetic susceptibility refers to how variations in a person’s genes increase or decrease his or her susceptibility to environmental factors, such as chemicals, radiation and lifestyle (diet and smoking). This volume will explore the latest findings in the area of genetic susceptibility to gastrointestinal cancers, focusing on molecular epidemiology, DNA repair, and gene-environment interactions to identify factors that affect the incidence of GI cancers. Topics will include germline susceptibility, including Mendelian patterns of inheritance and gene-environment interactions that lead to cancer etiology.
Hereditary and Familial Colorectal Cancer
Title | Hereditary and Familial Colorectal Cancer PDF eBook |
Author | Éanna Ryan |
Publisher | Cambridge Scholars Publishing |
Pages | 525 |
Release | 2022-10-17 |
Genre | Medical |
ISBN | 1527587355 |
This book describes the historical context of colorectal cancer predisposition syndromes and the latest knowledge relating to each of the known hereditary colorectal cancer predisposition syndromes. There is a particular focus on the management of each of these syndromes in turn, including medical and surgical management, cancer surveillance, and screening recommendations. It also explores the workings of specialised hereditary and familial cancer clinics from the perspectives of the various clinicians involved in the running of the service. Multidisciplinary management, universal tumour screening, risk estimation, the obtaining and use of genetic information, and appropriate high-risk population screening and surveillance are also discussed, as are future developments and how these may relate to this exciting and evolving field.
Optimizing Detection and Management of Familial and Hereditary Colorectal Cancer Syndromes
Title | Optimizing Detection and Management of Familial and Hereditary Colorectal Cancer Syndromes PDF eBook |
Author | Victorine Roos |
Publisher | |
Pages | 241 |
Release | 2021 |
Genre | |
ISBN | 9789493197626 |