Making Mice blends scientific biography, institutional history, and cultural history to show how genetically standardized mice came to play a central role in contemporary American biomedical research. Karen Rader introduces us to mouse "fanciers" who bred mice for different characteristics, to scientific entrepreneurs like geneticist C. C. Little, and to the emerging structures of modern biomedical research centered around the National Institutes of Health. Throughout Making Mice, Rader explains how the story of mouse research illuminates our understanding of key issues in the history of science such as the role of model organisms in furthering scientific thought. Ultimately, genetically standardized mice became icons of standardization in biomedicine by successfully negotiating the tension between the natural and the man-made in experimental practice. This book will become a landmark work for its understanding of the cultural and institutional origins of modern biomedical research. It will appeal not only to historians of science but also to biologists and medical researchers.

These cross-curricular activities for Of Mice and Men incorporate key skills for college and career readiness. The activities integrate literature with social studies, science, mathematics, and more. Activity pages engage and challenge students.

The author of Negotiating the Impossible “tackles our assumptions about business and life with humor, zest, and wisdom in this delightful fable” (Daniel H. Pink, New York Times-bestselling author). If you were a mouse trapped in a maze and someone kept moving the cheese, what would you do? In a world where most mice dutifully accept their circumstances, ask no questions, and keep chasing the cheese, Deepak Malhotra tells an inspiring story about three unique and adventurous mice—Max, Big, and Zed—who refuse to accept their reality as given. I Moved Your Cheese reveals what is possible when we finally discard long-held and widely accepted assumptions about how we should live our lives. After all, achieving extraordinary success, personal or professional, has always depended on the ability to challenge assumptions, reshape the environment, and play by a different set of rules—our own. But rejecting deeply ingrained beliefs is not easy. As Zed explains, “You see, Max, the problem is not that the mouse is in the maze, but that the maze is in the mouse.” “Deepak Malhotra allows you to glimpse a world of your own making without the limits and barriers that others create.” —Stephen R. Covey, New York Times-bestselling author of The 7 Habits of Highly Effective People “A magnificent story with a powerful message. As someone who has encouraged scores of professionals into breaking through the maze and defining their own pursuits, I find this to be a gem of a book.” —Vinod Khosla, cofounder, former CEO and Chairman, Sun Microsystems, and founder, Khosla Ventures “This book’s message is both profound and durable. Malhotra has left the maze, and so can we.” —Foreword Reviews

In the years since the third edition of this indispensable reference was published, a great deal has been learned about the nutritional requirements of common laboratory species: rat, mouse, guinea pig, hamster, gerbil, and vole. The Fourth Revised Edition presents the current expert understanding of the lipid, carbohydrate, protein, mineral, vitamin, and other nutritional needs of these animals. The extensive use of tables provides easy access to a wealth of comprehensive data and resource information. The volume also provides an expanded background discussion of general dietary considerations. In addition to a more user-friendly organization, new features in this edition include: A significantly expanded section on dietary requirements for rats, reporting substantial new findings. A new section on nutrients that are not required but that may produce beneficial results. New information on growth and reproductive performance among the most commonly used strains of rats and mice and on several hamster species. An expanded discussion of diet formulation and preparationâ€"including sample diets of both purified and natural ingredients. New information on mineral deficiency and toxicity, including warning signs. This authoritative resource will be important to researchers, laboratory technicians, and manufacturers of laboratory animal feed.

Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic

Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.