Major Histocompatibility Complex (MHC) in Health and Disease
Title | Major Histocompatibility Complex (MHC) in Health and Disease PDF eBook |
Author | Jerzy K. Kulski |
Publisher | MDPI |
Pages | 374 |
Release | 2020-01-15 |
Genre | Science |
ISBN | 3039280724 |
The major histocompatibility complex (MHC) is a highly polymorphic and diverse multigene locus in all jawed vertebrate species that has an integral role in adaptive/innate immune systems, transplantation, and infectious and autoimmune diseases. The MHC supra-locus in mammalian vertebrates is usually partitioned into three distinct regions, known as classes I, II, and III, which, to varying extents, can be found conserved in nonmammalian jawed vertebrates, such as bony fish, amphibians, and bird lineages. The MHC gene region is characterized particularly by the expression of class I and class II glycoproteins that bind peptides derived from intracellular or extracellular antigens to circulating T-cells. While this expressed antigenic specificity remains the predominant interest with respect to MHC function and polymorphism in a population, a broader concept has emerged that examines the MHC as a multifunctional polymorphic controller that facilitates and regulates genome diversity with a much greater array of functions and effects than just MHC-restricted antigen recognition. This volume of 19 reprints presented by various experts and collected from the Special Issue of Cells on “MHC in Health and Disease” covers a broad range of topics on the genomic diversity of the MHC regulatory system in various vertebrate species, including MHC class I, II, and III genes; innate and adaptive immunity; neurology; transplantation; haplotypes; infectious and autoimmune diseases; fecundity; conservation; allelic lineages; and evolution. Taken together, these articles demonstrate the immense complexity and diversity of the MHC structure and function within and between different vertebrate species.
Janeway's Immunobiology
Title | Janeway's Immunobiology PDF eBook |
Author | Kenneth Murphy |
Publisher | Garland Science |
Pages | |
Release | 2010-06-22 |
Genre | Medical |
ISBN | 9780815344575 |
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Major Histocompatibility Complex (MHC) in Health and Disease
Title | Major Histocompatibility Complex (MHC) in Health and Disease PDF eBook |
Author | Jerzy K. Kulski |
Publisher | |
Pages | 375 |
Release | 2020 |
Genre | Biology (General) |
ISBN | 9783039280735 |
The major histocompatibility complex (MHC) is a highly polymorphic and diverse multigene locus in all jawed vertebrate species that has an integral role in adaptive/innate immune systems, transplantation, and infectious and autoimmune diseases. The MHC supra-locus in mammalian vertebrates is usually partitioned into three distinct regions, known as classes I, II, and III, which, to varying extents, can be found conserved in nonmammalian jawed vertebrates, such as bony fish, amphibians, and bird lineages. The MHC gene region is characterized particularly by the expression of class I and class II glycoproteins that bind peptides derived from intracellular or extracellular antigens to circulating T-cells. While this expressed antigenic specificity remains the predominant interest with respect to MHC function and polymorphism in a population, a broader concept has emerged that examines the MHC as a multifunctional polymorphic controller that facilitates and regulates genome diversity with a much greater array of functions and effects than just MHC-restricted antigen recognition. This volume of 19 reprints presented by various experts and collected from the Special Issue of Cells on “MHC in Health and Disease” covers a broad range of topics on the genomic diversity of the MHC regulatory system in various vertebrate species, including MHC class I, II, and III genes; innate and adaptive immunity; neurology; transplantation; haplotypes; infectious and autoimmune diseases; fecundity; conservation; allelic lineages; and evolution. Taken together, these articles demonstrate the immense complexity and diversity of the MHC structure and function within and between different vertebrate species.
The Major Histocompatibility Complex (MHC/ HLA) in Medicine
Title | The Major Histocompatibility Complex (MHC/ HLA) in Medicine PDF eBook |
Author | Federico Garrido |
Publisher | Springer Nature |
Pages | 116 |
Release | |
Genre | |
ISBN | 3031598660 |
Hla and Mhc
Title | Hla and Mhc PDF eBook |
Author | Michael Browning |
Publisher | |
Pages | 438 |
Release | 1999-09-01 |
Genre | Medical |
ISBN | 9780122204388 |
The major histocompatibility complex (MHC) and its gene products have a major impact on health and disease through their central role in the regulation of the immune response. While the MHC has evolved as part of the host's defense strategy to protect against infection with pathogenic microorganisms, its gene products also form the major targets for rejection of allogenetic tissues in organ transplantation and susceptibility to a variety of diseases. This complex role in the health of the host has made the MHC the focus of attention in many fields of biological research. HLA and MHC: Genes, Molecules and Function is an authoritative review of the major histocompatibility complex, from the molecular genetics of the MHC through the structure and function of MHC-encoded molecules and their role in health and disease. The emphasis is on the human MHC, but relevant animal studies are also included to provide a comprehensive coverage of the subject. Internationally recognized experts in their respective fields of research have contributed individual chapters. This major new publication will be of interest not only to immunologists, but also to scientists and clinicians in a wide range of fields in which immune response plays a role.
Major Histocompatibility Complex
Title | Major Histocompatibility Complex PDF eBook |
Author | Natalya V. Semiletova |
Publisher | Nova Science Publishers |
Pages | 0 |
Release | 2012 |
Genre | Major histocompatibility complex |
ISBN | 9781619429994 |
This book represents original findings and observations that were made recently on the role and function of MHC proteins in different laboratories around the globe. The articles in this book cover topics from the importance of MHC diversity to the health of the wildlife to intimate molecular mechanisms of MHC exchange between cells. This book will be useful to a wide range of scientists and clinicians who are working in the field of immunology, transplantation and cancer research.
The Major Histocompatibility Complex (MHC) Gene Expression in Health and Disease
Title | The Major Histocompatibility Complex (MHC) Gene Expression in Health and Disease PDF eBook |
Author | Ratanasuda Roslin Russell |
Publisher | |
Pages | |
Release | 2004 |
Genre | |
ISBN |