This collection from the 12th International Conference on Magnesium Alloys and Their Applications (Mg 2021)—the longest running conference dedicated to the development of magnesium alloys—covers the breadth of magnesium research and development, from primary production to applications to end-of-life management. Authors from academia, government, and industry discuss new developments in magnesium alloys and share valuable insights. Topics in this volume include but are not limited to the following: Primary production Alloy development Solidification and casting processes Forming and thermo-mechanical processing Other manufacturing process development (including joining and additive manufacturing) Corrosion and protection Modeling and simulation Structural, functional, biomedical, and energy applications Advanced characterization and fundamental theories Recycling and environmental issues

The Magnesium Technology Symposium, the event on which this collection is based, is one of the largest yearly gatherings of magnesium specialists in the world. Papers represent all aspects of the field, ranging from primary production to applications to recycling. Moreover, papers explore everything from basic research findings to industrialization. Magnesium Technology 2021 is a definitive reference that covers a broad spectrum of current topics, including novel extraction techniques; primary production; alloys and their production; thermodynamics and kinetics; cast products and processing; wrought products and processing; forming, joining, and machining; corrosion and surface finishing; structural applications; degradation and biomedical applications; and several others.

The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

The book provides an introduction to the topic of magnesium materials for biomedical applications. Additional to the background on magnesium’s physical, chemical and mechanical properties, areas of use, related diseases and pathways for biodegradation will be discussed. Also, an outlook of the future of magnesium material applications will be provided.

There is a large and rapidly growing body of literature on the importance of mag nesium in biochemical and physiological processes. There is also much evidence that magnesium deficiency, alone and in combination with agents that interfere with its utilization, is associated with functional and structural abnormalities of mem branes, cells, organs, and systems. The manifestations of the changes caused by magnesium deficiency depend upon its extent and duration and on variable factors. Among the conditions that increase the risk of magnesium deficiency are (1) meta bolic factors that affect the absorption, distribution, and excretion of this mineral; (2) disease and therapy; (3) physiologic states that increase requirements for nutrients; and (4) nutritional imbalances. Excesses of nutrients that interfere with the absorption or increase the excretion of magnesium-such as fat, phosphate, sugar, and vitamin D-can contribute to long-lasting relative magnesium deficiency. All have been implicated in several of the diseases considered in this book. Whether their influence on the need for magnesium is a common denominator remains to be investigated further.

The Magnesium Technology Symposium at the TMS Annual Meeting & Exhibition is one of the largest yearly gatherings of magnesium specialists in the world. Papers represent all aspects of the field, ranging from primary production to applications and recycling. Moreover, papers explore everything from basic research findings to industrialization. Magnesium Technology 2022 is a definitive reference that covers a broad spectrum of current topics, including novel extraction techniques; primary production; alloys and their production; integrated computational materials engineering; thermodynamics and kinetics; plasticity mechanisms; cast products and processing; wrought products and processing; forming, joining, and machining; corrosion and surface finishing; fatigue and fracture; dynamic response; structural applications; degradation and biomedical applications; emerging applications; additive manufacturing of powders; and recycling, ecological issues, and life cycle analysis.

Magnesium (Mg) and its alloys have received widespread acceptance in automobile industries and biomedical applications with substantial recent advancements made in their development, however a significant limitation remains their poor aqueous and galvanic corrosion resistance. This book covers both the fundamentals and recent advancements in two major corrosion protection strategies of magnesium and its alloys, namely, metal-matrix composites and protective coatings. Key features: Covers all aspects of metal-matrix composites and protective coatings for magnesium alloys to improve their corrosion resistance, wear resistance, mechanical properties and biocompatibility Provides the most recent research advancements in the corrosion mitigation strategies of magnesium and its alloys Complete with case studies specific to practical applications, this book serves as a ready reference for graduate students, researchers, engineers and industry professionals in the fields of materials, corrosion science, biofouling and protective coatings.