The first comprehensive book focusing on synthesis and applications of macrocyclic polyamines and their derivatives Macrocyclic polyamines are a class of widely used important compounds. This is the first book that systematically summarizes the synthesis and applications of macrocyclic polyamines and their analogues, including the properties and synthetic methods of macrocyclic polyamines, chemical nucleases based on macrocyclic polyamines, the derivatives of macrocyclic polyamines as nano-vector materials, macrocyclic polyamines derivatives for bio-imaging, chemical sensors based on macrocyclic polyamines, and other applications of macrocyclic polyamines. Macrocyclic Polyamines: Synthesis and Applications includes most of the studies involving macrocyclic polyamines and their derivatives, and may be used as a reference for the researchers in related fields. It offers in-depth coverage of cyclization modes; special procedures for tetraza macrocyclic compounds; diacids-diamines condensation; oxidative DNA cleaving by macrocyclic polyamines; lipids with cationic MPA headgroups; the derivatives of DOTA, DO3A, and PCTA; receptors for anions; sensors for bioactive molecules; macrocyclic polyamines for solvent extraction and membrane transport of amino acids and their derivatives, electrophoretic separation, and open-tubular CEC; and much more. ?The first book that systematically summarizes the chemistry of macrocyclic polyamines and their derivatives in terms of synthetic methods for their preparation, functionalization, and application in the main fields of chemical sensors, chemical nucleases, drug-delivery, bio-imaging and vector materials ?Provides a comprehensive reference for the researchers working on macrocyclic polyamines ?Offers train of thought in related research fields such as organic chemistry, coordination chemistry, analytical chemistry, supramolecular chemistry, biomaterials, etc. Macrocyclic Polyamines: Synthesis and Applications will not only provide a reference for the researchers working on macrocyclic polyamines, but also offer opportunities for researchers in related research fields to understand the benefits of these key compounds.

Five new macrocyclic polyamine fluorophores containing two dansylamidoethyl side arms (3a-3e) have been prepared. As shown in Scheme 1, the appropriate macrocyclic polyamine (la-le) was treated with N-dansylaziridine in acetonitrile to form 3a-3e. The yields of the new fluorophores are given in the scheme.

The significance of polyamines in cell proliferation and carcinogenesis has stimulated further research interest in their biochemistry and metabolism. These papers, which update the available literature on polyamines, are grouped into four main areas: the metabolism of polyamines; the effect of polyamines on cellular metabolism; inhibitors of polyamine metabolism and their clinical relevance; application to diagnosis and prognosis. The Proceedings include contributions from a wide range of research interests with special emphasis being placed on the clinical aspects of these compounds.

The area of polyamines is presented in this useful, two-volume publication. Basic information describing the role of polyamines in the processes of growth and differentiation is given. Also included are data on the regulation of polyamine biosynthesis and metabolism and their interactions with nucleic acids. Several chapters are devoted to the role of polyamines in various aspects of plant biology, with a special emphasis on their participation in the response of plants to extreme environments. Special attention is given to the use of inhibitors of polyamine biosynthesis as potential antitumor and antiproliferative agents. Additionally, progress in the molecular biology and genetic engineering of genes coding for polyamine biosynthetic enzymes is described. Cancer researchers, biologists, geneticists, biochemists, physiologists, and clinicians will find this volume indispensable.

The area of polyamines is presented in this useful, two-volume publication. Basic information describing the role of polyamines in the processes of growth and differentiation is given. Also included are data on the regulation of polyamine biosynthesis and metabolism and their interactions with nucleic acids. Several chapters are devoted to the role of polyamines in various aspects of plant biology, with a special emphasis on their participation in the response of plants to extreme environments. Special attention is given to the use of inhibitors of polyamine biosynthesis as potential antitumor and antiproliferative agents. Additionally, progress in the molecular biology and genetic engineering of genes coding for polyamine biosynthetic enzymes is described. Cancer researchers, biologists, geneticists, biochemists, physiologists, and clinicians will find this volume indispensable.